Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Berndt, Sonja-I; Lan, Qing; Hartge, Patricia; Goldin, Lynn-R; Caporaso, Neil-E; Morton, Lindsay-M; Albanese, Demetrius; Weinstein, Stephanie; Chatterjee, Nilanjan; Fraumeni, Joseph-F; Chanock, Stephen-J; Rothman, Nathaniel; Camp, Nicola-J; Arnett, Donna-K; Skibola, Christine-F; Conde, Lucia; Riby, Jacques; Vijai, Joseph; Villano, Danylo-J; Maria, Ann; Offit, Kenneth; Wang, Zhaoming; Yeager, Meredith; Burdett, Laurie; Hutchinson, Amy; Gu, Jian; Ye, Yuanqing; Strom, Sara-S; Wu, Xifeng; Nieters, Alexandra; Huang, Jinyan; Kelly, Rachel-S; Smedby, Karin-E; Clavel, Jacqueline; Monnereau, Alain; Cozen, Wendy; Cox, Angela; Wang, Sophia-S; Teras, Lauren-R; Diver, W-Ryan; Machado, Moara; Brooks-Wilson, Angela-R; Purdue, Mark-P; Birmann, Brenda-M; Bertrand, Kimberly-A; Vajdic, Claire-M; Cocco, Pierluigi; Zhang, Yawei; Zheng, Tongzhang; Giles, Graham-G; Milne, Roger-L; Zeleniuch-Jacquotte, Anne; Lawrence, Charles; Montalvan, Rebecca; Call, Timothy-G; Kay, Neil-E; Shanafelt, Tait-D; Novak, Anne-J; Liebow, Mark; Cunningham, Julie-M; Allmer, Cristine; Chaffee, Kari-G; Achenbach, Sara-J; Vachon, Celine-M; Norman, Aaron-D; Cerhan, James-R; Slager, Susan-L; Hjalgrim, Henrik; Adami, Hans-Olov; Melbye, Mads; Glimelius, Bengt; Chang, Ellen-T; Glenn, Martha; Curtin, Karen; Cannon-Albright, Lisa-A; Link, Brian-K; Weiner, George-J; Bracci, Paige-M; Holly, Elizabeth-A; Zhi, Degui; Leach, Justin-M; Jackson, Rebecca-D; Tinker, Lesley-F; Benavente, Yolanda; de-Sanjose, Silvia; Sala, Nuria; Casabonne, Delphine; Becker, Nikolaus; Kaaks, Rudolph; Boffetta, Paolo; Brennan, Paul; McKay, James; Foretova, Lenka; Maynadie, Marc; Staines, Anthony; Leis, José-F; Weinberg, J-Brice; De-Roos, Anneclaire-J; Severson, Richard-K; Riboli, Elio; Vineis, Paolo; Masala, Giovanna; Weiderpass, Elisabete; Chirlaque-López, María-Dolores; Vermeulen, Roel-C-H; Travis, Ruth-C; Southey, Melissa-C; Virtamo, Jarmo; Holford, Theodore-R; Spinelli, John-J; Gascoyne, Randy-D; Connors, Joseph-M; Giovannucci, Edward; Kraft, Peter; Liang, Liming; Kricker, Anne; Turner, Jenny; Ennas, María-Grazia; Ferri, Giovanni-M; Miligi, Lucia; Ma, Baoshan; Crouch, Simon; Park, Ju-Hyun; North, Kari-E; Snowden, John-A; Wright, Josh

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dc.contributor.author	Berndt, Sonja-I
dc.contributor.author	Lan, Qing
dc.contributor.author	Hartge, Patricia
dc.contributor.author	Goldin, Lynn-R
dc.contributor.author	Caporaso, Neil-E
dc.contributor.author	Morton, Lindsay-M
dc.contributor.author	Albanese, Demetrius
dc.contributor.author	Weinstein, Stephanie
dc.contributor.author	Chatterjee, Nilanjan
dc.contributor.author	Fraumeni, Joseph-F
dc.contributor.author	Chanock, Stephen-J
dc.contributor.author	Rothman, Nathaniel
dc.contributor.author	Camp, Nicola-J
dc.contributor.author	Arnett, Donna-K
dc.contributor.author	Skibola, Christine-F
dc.contributor.author	Conde, Lucia
dc.contributor.author	Riby, Jacques
dc.contributor.author	Vijai, Joseph
dc.contributor.author	Villano, Danylo-J
dc.contributor.author	Maria, Ann
dc.contributor.author	Offit, Kenneth
dc.contributor.author	Wang, Zhaoming
dc.contributor.author	Yeager, Meredith
dc.contributor.author	Burdett, Laurie
dc.contributor.author	Hutchinson, Amy
dc.contributor.author	Gu, Jian
dc.contributor.author	Ye, Yuanqing
dc.contributor.author	Strom, Sara-S
dc.contributor.author	Wu, Xifeng
dc.contributor.author	Nieters, Alexandra
dc.contributor.author	Huang, Jinyan
dc.contributor.author	Kelly, Rachel-S
dc.contributor.author	Smedby, Karin-E
dc.contributor.author	Clavel, Jacqueline
dc.contributor.author	Monnereau, Alain
dc.contributor.author	Cozen, Wendy
dc.contributor.author	Cox, Angela
dc.contributor.author	Wang, Sophia-S
dc.contributor.author	Teras, Lauren-R
dc.contributor.author	Diver, W-Ryan
dc.contributor.author	Machado, Moara
dc.contributor.author	Brooks-Wilson, Angela-R
dc.contributor.author	Purdue, Mark-P
dc.contributor.author	Birmann, Brenda-M
dc.contributor.author	Bertrand, Kimberly-A
dc.contributor.author	Vajdic, Claire-M
dc.contributor.author	Cocco, Pierluigi
dc.contributor.author	Zhang, Yawei
dc.contributor.author	Zheng, Tongzhang
dc.contributor.author	Giles, Graham-G
dc.contributor.author	Milne, Roger-L
dc.contributor.author	Zeleniuch-Jacquotte, Anne
dc.contributor.author	Lawrence, Charles
dc.contributor.author	Montalvan, Rebecca
dc.contributor.author	Call, Timothy-G
dc.contributor.author	Kay, Neil-E
dc.contributor.author	Shanafelt, Tait-D
dc.contributor.author	Novak, Anne-J
dc.contributor.author	Liebow, Mark
dc.contributor.author	Cunningham, Julie-M
dc.contributor.author	Allmer, Cristine
dc.contributor.author	Chaffee, Kari-G
dc.contributor.author	Achenbach, Sara-J
dc.contributor.author	Vachon, Celine-M
dc.contributor.author	Norman, Aaron-D
dc.contributor.author	Cerhan, James-R
dc.contributor.author	Slager, Susan-L
dc.contributor.author	Hjalgrim, Henrik
dc.contributor.author	Adami, Hans-Olov
dc.contributor.author	Melbye, Mads
dc.contributor.author	Glimelius, Bengt
dc.contributor.author	Chang, Ellen-T
dc.contributor.author	Glenn, Martha
dc.contributor.author	Curtin, Karen
dc.contributor.author	Cannon-Albright, Lisa-A
dc.contributor.author	Link, Brian-K
dc.contributor.author	Weiner, George-J
dc.contributor.author	Bracci, Paige-M
dc.contributor.author	Holly, Elizabeth-A
dc.contributor.author	Zhi, Degui
dc.contributor.author	Leach, Justin-M
dc.contributor.author	Jackson, Rebecca-D
dc.contributor.author	Tinker, Lesley-F
dc.contributor.author	Benavente, Yolanda
dc.contributor.author	de-Sanjose, Silvia
dc.contributor.author	Sala, Nuria
dc.contributor.author	Casabonne, Delphine
dc.contributor.author	Becker, Nikolaus
dc.contributor.author	Kaaks, Rudolph
dc.contributor.author	Boffetta, Paolo
dc.contributor.author	Brennan, Paul
dc.contributor.author	McKay, James
dc.contributor.author	Foretova, Lenka
dc.contributor.author	Maynadie, Marc
dc.contributor.author	Staines, Anthony
dc.contributor.author	Leis, José-F
dc.contributor.author	Weinberg, J-Brice
dc.contributor.author	De-Roos, Anneclaire-J
dc.contributor.author	Severson, Richard-K
dc.contributor.author	Riboli, Elio
dc.contributor.author	Vineis, Paolo
dc.contributor.author	Masala, Giovanna
dc.contributor.author	Weiderpass, Elisabete
dc.contributor.author	Chirlaque-López, María-Dolores
dc.contributor.author	Vermeulen, Roel-C-H
dc.contributor.author	Travis, Ruth-C
dc.contributor.author	Southey, Melissa-C
dc.contributor.author	Virtamo, Jarmo
dc.contributor.author	Holford, Theodore-R
dc.contributor.author	Spinelli, John-J
dc.contributor.author	Gascoyne, Randy-D
dc.contributor.author	Connors, Joseph-M
dc.contributor.author	Giovannucci, Edward
dc.contributor.author	Kraft, Peter
dc.contributor.author	Liang, Liming
dc.contributor.author	Kricker, Anne
dc.contributor.author	Turner, Jenny
dc.contributor.author	Ennas, María-Grazia
dc.contributor.author	Ferri, Giovanni-M
dc.contributor.author	Miligi, Lucia
dc.contributor.author	Ma, Baoshan
dc.contributor.author	Crouch, Simon
dc.contributor.author	Park, Ju-Hyun
dc.contributor.author	North, Kari-E
dc.contributor.author	Snowden, John-A
dc.contributor.author	Wright, Josh
dc.date.accessioned	2026-10-21T06:19:47Z
dc.date.available	2026-10-21T06:19:47Z
dc.date.issued	2016-03-09
dc.identifier.citation	Berndt SI, Camp NJ, Skibola CF, Vijai J, Wang Z, Gu J, et al. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Nat Commun. 9 de marzo de 2016;7(1):10933. doi:10.1038/ncomms10933
dc.identifier.issn	2041-1723
dc.identifier.uri	https://sms.carm.es/ricsmur/handle/123456789/28869
dc.description.abstract	Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
dc.language.iso	eng
dc.rights	Atribución/Reconocimiento 4.0 Internacional
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/deed.es	*
dc.subject.mesh	Adaptor Proteins, Signal Transducing/genetics
dc.subject.mesh	Apoptosis Regulatory Proteins/genetics
dc.subject.mesh	Bcl-2-Like Protein 11
dc.subject.mesh	Genetic Predisposition to Disease
dc.subject.mesh	Genome-Wide Association Study
dc.subject.mesh	Humans
dc.subject.mesh	Leukemia, Lymphocytic, Chronic, B-Cell/genetics
dc.subject.mesh	Membrane Proteins/genetics
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	Proto-Oncogene Proteins/genetics
dc.subject.mesh	Serpins/genetics
dc.subject.mesh	T-Box Domain Proteins/genetics
dc.subject.mesh	White People/genetics
dc.title	Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
dc.type	info:eu-repo/semantics/article
dc.identifier.pmid	26956414
dc.relation.publisherversion	https://www.nature.com/articles/ncomms10933
dc.identifier.doi	10.1038/ncomms10933
dc.journal.title	Nature Communications