Repositorio Dspace

Listar por tema "Xenograft Model Antitumor Assays"

Listar por tema "Xenograft Model Antitumor Assays"

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  • A novel chimeric antigen receptor T-cell therapy targeting CD84 for the treatment of acute myeloid and T-cell lymphoblastic leukemias 
    Pérez-Amill, Lorena; Armand-Ugon, Mercedes; Val-Casals, María; Martín-Herreros, Beatriz; Álamo, José-R; Peña, Sergio; Frigola, Gerard; Altuna, Ane; Santos, Claudio; Guijarro, Francesca; Minguela-Puras, Alfredo; Bataller, Alex; Casanovas-Alberti, Berta; Uribe-Herranz, Mireia; Navarro, Irene; Guerreiro, Manuel; Sánchez-Martínez, Diego; Tirado, Nestor; Velasco-Hernández, Talia; Menéndez, Pablo; Martínez, Antonio; Rovira, Montse; Colomer, Dolors; González-Navarro, Europa-Azucena; Esteve, Jordi; Urbano-Ispizua, Álvaro; Montesinos, Pau; Delgado, Julio; Juan, Manel; Klein-González, Nela (SPRINGERNATURE, 2025-10)
    Despite the remarkable clinical successes of chimeric antigen receptor (CAR) T-cell therapies in treating B-cell malignancies and multiple myeloma, similar outcomes have not been achieved in other indications. For patients ...
  • A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance 
    Liaki, Vasiliki; Barrambana, Sara; Kostopoulou, Myrto; Lechuga, Carmen-G; Zamorano-Domínguez, Elena; Acosta-Gallego, Domingo; Morales-Cacho, Lucía; Álvarez, Ruth; Sun, Pian; Rosas-Pérez, Blanca; Barrero, Rebeca; Jiménez-Parrado, Silvia; López-García, Alejandra; San-Roman, Marta; López-Gil, Juan-Carlos; Drosten, Matthias; Sainz, Bruno; Musteanu, Mónica; Caleiras, Eduardo; Dusetti, Nelson; Poli, Valeria; Sánchez-Bueno, Francisco; Guerra, Carmen; Barbacid, Mariano (NATL ACAD SCIENCES, 2026-06-09)
    Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to more efficacious therapies although their beneficial effect is still limited ...
  • MET pathway inhibition increases chemo-immunotherapy efficacy in small cell lung cancer 
    del Rey-Vergara, Raul; Galindo-Campos, Miguel Alejandro; Rocha, Pedro; Carpes, Marina; Martinez, Carlos; Masfarre, Laura; Menendez, Silvia; Quimis, Fabricio; Rossell, Adria; Inanez, Albert; Perez-Buira, Sandra; Rojo, Federico; Gimeno, Ramon; Isla, Dolores; Zugazagoitia, Jon; Blanco, Cristina Marti; Garcia-Campelo, Rosario; Moreno-Vega, Alberto; Leon-Mateos, Luis; Mellen, Angel Callejo; Park, Kwon-Sik; Heeke, Simon; Heymach, John V.; Taus, Alvaro; Paz-Ares, Luis; Rovira, Ana; Arriola, Edurne (CELL PRESS, 2025-07)
    The introduction of immunotherapy as a first-line treatment for advanced small cell lung cancer (SCLC) represents significant progress, yet there remains an opportunity to further improve patient outcomes. Hepatocyte growth ...
  • NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia 
    López-Millan, Belén; Sánchez-Martínez, Diego; Roca-Ho, Heleia; Gutiérrez-Agüera, Francisco; Molina, Oscar; Díaz-de-la-Guardia, Rafael; Torres-Ruiz, Raul; Fuster-Soler, José-Luis; Ballerini, Paola; Suessbier, Ute; Nombela-Arrieta, Cesar; Bueno, Clara; Menéndez, Pablo (NATURE PUBLISHING GROUP, 2019-07)
    B cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer, with cure rates of ?80%. MLL-rearranged (MLLr) B-ALL (MLLr-B-ALL) has, however, an unfavorable prognosis with common therapy refractoriness ...
  • PRMT1-dependent methylation of BRCA1 contributes to the epigenetic defense of breast cancer cells against ionizing radiation 
    Montenegro, María-F; González-Guerrero, Rebeca; Sánchez-del-Campo, Luis; Piñero-Madrona, Antonio; Cabezas-Herrera, Juan; Rodríguez-López, José-Neptuno (NATURE PORTFOLIO, 2020-08-06)
    The therapeutic effect of irradiation is thought to come from DNA damage that affects rapidly proliferating cancer cells; however, resistant cells rapidly initiate mechanisms to repair such damage. While DNA repair mechanisms ...