Repositorio Dspace

Listar por tema "T-Lymphocytes/immunology"

Listar por tema "T-Lymphocytes/immunology"

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  • Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity 
    Zanetti, Samanta-Romina; Romecin, Paola-Alejandra; Vinyoles, Meritxell; Juan, Manel; Fuster-Soler, José-Luis; Camos, Mireia; Querol, Sergi; Delgado, Mario; Menéndez, Pablo (BMJ PUBLISHING GROUP, 2020)
    BACKGROUND: Although adoptive transfer of CD19-directed chimeric antigen receptor (CAR) T-cells (CD19-CAR T-cells) achieves high rates of complete response in patients with B-cell acute lymphoblastic leukemia (B-ALL), ...
  • PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas 
    Navarro, Judith; Gozalbo-López, Beatriz; Mendez, Andrea-C; Dantzer, Francoise; Schreiber, Valerie; Martínez, Carlos; Arana, David-M; Farres, Jordi; Revilla-Nuin, Beatriz; Bueno, María-F; Ampurdanes, Coral; Galindo-Campos, Miguel-A; Knobel, Philip-A; Segura-Bayona, Sandra; Martín-Caballero, Juan; Stracker, Travis-H; Aparicio, Pedro; del-Val, Margarita; Yelamos, José (NATURE PORTFOLIO, 2017-02-09)
    The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function. Mice bearing ...