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Listar por tema "Neoplasm Invasiveness"

Listar por tema "Neoplasm Invasiveness"

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  • Bcl-xL: A Focus on Melanoma Pathobiology 
    Lucíano, Anna-María; Pérez-Oliva, Ana-Belén; Mulero, Victoriano; del-Bufalo, Donatella (MDPI, 2021-03)
    Apoptosis is the main mechanism by which multicellular organisms eliminate damaged or unwanted cells. To regulate this process, a balance between pro-survival and pro-apoptotic proteins is necessary in order to avoid ...
  • CDCA7 finely tunes cytoskeleton dynamics to promote lymphoma migration and invasion 
    Martín-Cortazar, Carla; Chiodo, Yuri; Jiménez-P, Raúl; Bernabé, Manuel; Cayuela-Fuentes, María-Luisa; Iglesias, Teresa; Campanero, Miguel-R (FERRATA STORTI FOUNDATION, 2020-03-01)
    Metastases, the major cause of death from cancer, require cells' acquisition of the ability to migrate and involve multiple steps, including local tumor cell invasion and basement membrane penetration. Certain lymphoid ...
  • MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NF?B axis 
    García-Castillo, Jesús; Martínez-Cáceres, Carlos-Manuel; Bernabé-García, Manuel; Munitiz-Ruiz, Vicente; Ruiz-de-Angulo, David; Parrilla-Paricio, Pascual; Ortiz, Ángeles; Martínez-de-Haro, Luisa-Fernanda; Cayuela-Fuentes, María-Luisa (WILEY, 2025-11)
    Barrett's esophagus (BE) is a premalignant lesion that can lead to an invasive esophageal adenocarcinoma (EAC), a type of cancer that usually has a poor outcome. We have previously described a set of four microRNAs (miR-192, ...
  • Monastrol suppresses invasion and metastasis in human colorectal cancer cells by targeting fascin independent of kinesin-Eg5 pathway 
    Alburquerque-González, Begoña; Montoro-García, Silvia; Bernabé-García, Ángel; Bernabé-García, Manuel; Campioni-Rodrigues, Priscila; Rodríguez-Martínez, Alejandro; Luque, Irene; Salo, Tuula; Pérez-Garrido, Alfonso; Pérez-Sánchez, Horacio; Cayuela-Fuentes, María-Luisa; Luengo-Gil, Ginés; Luchinat, Enrico; Postigo-Corrales, Fátima; Staderini, Tommaso; Nicolás, Francisco-José; Conesa-Zamora, Pablo (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2024-06)
    Rearrangement of the actin cytoskeleton is a prerequisite for carcinoma cells to develop cellular protrusions, which are required for migration, invasion, and metastasis. Fascin is a key protein involved in actin bundling ...
  • NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia 
    López-Millan, Belén; Sánchez-Martínez, Diego; Roca-Ho, Heleia; Gutiérrez-Agüera, Francisco; Molina, Oscar; Díaz-de-la-Guardia, Rafael; Torres-Ruiz, Raul; Fuster-Soler, José-Luis; Ballerini, Paola; Suessbier, Ute; Nombela-Arrieta, Cesar; Bueno, Clara; Menéndez, Pablo (NATURE PUBLISHING GROUP, 2019-07)
    B cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer, with cure rates of ?80%. MLL-rearranged (MLLr) B-ALL (MLLr-B-ALL) has, however, an unfavorable prognosis with common therapy refractoriness ...
  • The effect of fascin 1 inhibition on head and neck squamous cell carcinoma cells 
    Wahab, Awais; Hyytiainen, Aini; Wahbi, Wafa; Tuomainen, Katja; Tervo, Sanni; Conesa-Zamora, Pablo; Jauhiainen, Laura; Makinen, Laura-K; Paavonen, Timo; Toppila-Salmi, Sanna; Salem, Abdelhakim; Almangush, Alhadi; Salo, Tuula; Al-Samadi, Ahmed (WILEY, 2021-12)
    Fascin 1 plays important pro-metastatic roles in head and neck carcinoma (HNSCC) migration, invasion, and metastasis. However, limited advancement in targeting metastasis remains a major obstacle in improving HNSCC patients' ...
  • The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination 
    Crosas-Molist, E; Bertran, E; Rodríguez-Hernández, I; Herraiz, C; Cantelli, G; Fabra, A; Sanz-Moreno, V; Fabregat, I (NATURE PUBLISHING GROUP, 2017-05-25)
    Epithelial to mesenchymal transition is a common event during tumour dissemination. However, direct epithelial to amoeboid transition has not been characterized to date. Here we provide evidence that cells from hepatocellular ...