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Listar por tema "Male"

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  • 250 cases of "type 2 Gaucher disease": A novel system of clinical categorisation and evidence of genotype: Phenotype correlation 
    Donald, A; Brothwell, S; Cabello, B-M; Ehrstedt, C; Fernández-Fructuoso, Jose-Ramón; Fernández-Marin, E; González-Lamuno, D; Lloreda-García, José-María; Lykopoulou, L; Mignot, C; Nurse, J; O'Sullivan, S; Persson, A-N; Raiman, J; Rajan, D-S; Uberos, J; Jones, S-A; Church, H-J (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2025-06)
    'Type 2' Gaucher disease, also referred to as 'acute neuronopathic' or 'infantile' Gaucher disease is an aggressive subtype of Gaucher disease, resulting from pathogenic variants in GBA1. The spectrum of phenotype ranges ...
  • A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial, Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age 
    Pérez-Piñero, Silvia; Ávila-Gandía, Vicente; Rubio-Arias, Jacobo-A; Muñoz-Carrillo, Juan-Carlos; Losada-Zafrilla, Pilar; López-Román, Francisco-Javier (MDPI, 2021-12)
    The use of reclaimed water is considered an efficient tool for agricultural irrigation; however, the high salinity associated to this water could compromise plant quality and yields. Balm and spearmint plants were submitted ...
  • A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort 
    Christakoudi, Sofia; Tsilidis, Konstantinos-K; Muller, David-C; Freisling, Heinz; Weiderpass, Elisabete; Overvad, Kim; Soederberg, Stefan; Haeggstroem, Christel; Pischon, Tobias; Dahm, Christina-C; Zhang, Jie; Tjonneland, Anne; Halkjaer, Jytte; MacDonald, Conor; Boutro, (NATURE PORTFOLIO, 03/09/2020)
    Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass ...
  • A Chronic Ocular-Hypertensive Rat Model induced by Injection of the Sclerosant Agent Polidocanol in the Aqueous Humor Outflow Pathway 
    Blanco, Roman; Martínez-Navarrete, Gema; Pérez-Rico, Consuelo; Valiente-Soriano, Francisco-Javier; Avilés-Trigueros, Marcelino; Vicente, Javier; Fernández, Eduardo; Vidal-Sanz, Manuel; de-la-Villa, Pedro (MDPI, 2019-07-01)
    BACKGROUND: To induce a moderate chronic ocular hypertension (OHT) by injecting polidocanol, a foamed sclerosant drug, in the aqueous humor outflow pathway. METHODS: Intraocular pressure (IOP) was monitored for up to 6 ...
  • A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study 
    Imamura, Fumiaki; Sharp, Stephen-J; Koulman, Albert; Schulze, Matthias-B; Kroeger, Janine; Griffin, Julian-L; Huerta-Castaño, José-María; Guevara, Marcela; Sluijs, Ivonne; Agudo, Antonio; Ardanaz, Eva; Balkau, Beverley; Boeing, Heiner; Chajes, Veronique; Dahm, Christina-C; Dow, Courtney; Fagherazzi, Guy; Feskens, Edith-J-M; Franks, Paul-W; Gavrila-Chervase, Diana; Gunter, Marc; Kaaks, Rudolf; Key, Timothy-J; Khaw, Kay-Tee; Kuehn, Tilman; Melander, Olle; Molina-Portillo, Elena; Nilsson, Peter-M; Olsen, Anja; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Rolandsson, Olov; Sieri, Sabina; Sacerdote, Carlotta; Slimani, Nadia; Spijkerman, Annemieke-M-W; Tjonneland, Anne; Tumino, Rosario; van-der-Schouw, Yvonne-T; Langenberg, Claudia; Riboli, Elio; Forouhi, Nita-G; Wareham, Nick-J (PUBLIC LIBRARY SCIENCE, 2017-10)
    BACKGROUND: Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated. ...
  • A Comparative View on the Oviductal Environment during the Periconception Period 
    González-Brusi, Leopoldo; Algarra, Blanca; Moros-Nicolás, Carla; Izquierdo-Rico, María-José; Avilés, Manuel; Jiménez-Movilla, María (MDPI, 2020-12)
    The GATA1 transcription factor is essential for normal erythropoiesis and megakaryocytic differentiation. Germline GATA1 pathogenic variants in the N-terminal zinc finger (N-ZF) are typically associated with X-linked ...
  • A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study 
    Clasen, Joanna-L; Heath, Alicia-K; Van-Puyvelde, Heleen; Huybrechts, Inge; Park, Jin-Young; Ferrari, Pietro; Johansson, Mattias; Scelo, Ghislaine; Ulvik, Arve; Midttun, Oivind; Ueland, Per-Magne; Dahm, Christina-C; Halkjaer, Jytte; Olsen, Anja; Johnson, Theron; Katzke, Verena-A (ELSEVIER SCIENCE INC, 2021-07)
    Background: Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. ...
  • A correlative biomarker study and integrative prognostic model in chemotherapy-naive metastatic castration-resistant prostate cancer treated with enzalutamide 
    Fernández-Pérez, María-Piedad; Pérez-Navarro, Enrique; Alonso-Gordoa, Teresa; Conteduca, Vincenza; Font, Albert; Vázquez-Estevez, Sergio; González-del-Alba, Aranzazu; Wetterskog, Daniel; Antonarakis, Emmanuel-S; Mellado, Begoña; Fernández-Calvo, Ovidio; Méndez-Vidal, María (WILEY, 2023-03)
    BackgroundThere is a considerable need to incorporate biomarkers of resistance to new antiandrogen agents in the management of castration-resistant prostate cancer (CRPC). MethodsWe conducted a phase II trial of enzalutamide ...
  • A cost-effectiveness analysis of hypertrophic cardiomyopathy sudden cardiac death risk algorithms for implantable cardioverter defibrillator decision-making 
    Green, Nathan; Chen, Yang; O'Mahony, Constantinos; Elliott, Perry-M; Barriales-Villa, Roberto; Monserrat, Lorenzo; Anastasakis, Aris; Biagini, Elena; Gimeno-Blanes, Juan-Ramón; Limongelli, Giuseppe; Pavlou, Menelaos; Omar, Rumana-Z (OXFORD UNIV PRESS, 09/10/2023)
    Aims To conduct a contemporary cost-effectiveness analysis examining the use of implantable cardioverter defibrillators (ICDs) for primary prevention in patients with hypertrophic cardiomyopathy (HCM).Methods A discrete-time ...
  • A decade of changes in management of immune thrombocytopenia, with special focus on elderly patients 
    Lozano-Almela, María-Luisa; Mingot-Castellano, María-Eva; Perera, María-M; Jarque, Isidro; Campos-Álvarez, Rosa-M; González-López, Tomás-J; Carreño-Tarragona, Gonzalo; Bermejo, Nuria; López-Fernández, María-F; de-Andres, Aurora; Valcárcel, David; Casado-Montero, Luis-Felipe; Álvarez-R, (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2021-02)
    Background: Ten years after their availability, thrombopoietin receptor agonists (TPO-RA) have heralded a paradigm shift in the treatment of immune thrombocytopenia (ITP). This study was aimed to analyze the implementation ...
  • A degenerate Todani Ia choledochal cyst in a patient with pancreas divisum 
    Sánchez-Melgarejo, José-Francisco; Rubio-Mateos, José-Maria; Sánchez-Fernández, María-Josefa (ARAN EDICIONES, S A, 2019)
    Bile duct cysts represent congenital abnormalities associated with biliopancreatic maljunction that may undergo malignant degeneration. We report herein the case of a 72-year-old male patient with cholangitis. MR-cholangiography ...
  • A FCGR3A Polymorphism Predicts Anti-drug Antibodies in Chronic Inflammatory Bowel Disease Patients Treated With Anti-TNF 
    Romero-Cara, Patricia; Torres-Moreno, Daniel; Pedregosa, Jose; Vílchez, Juan-Antonio; García-Simón, María-Sergia; Ruiz-Merino, Guadalupe; Morán-Sánchez, Senador; Conesa-Zamora, Pablo (IVYSPRING INT PUBL, 2018)
    BACKGROUND: The production of anti-drug antibodies (ADAs) against IgG monoclonal antibodies (mAbs) targeting tumour necrosis factor (TNF) is an important cause of loss of response to anti-TNF mAbs in patients with inflammatory ...
  • A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review 
    Garrigos, Daniel; Martínez-Morga, Marta; Toval, Ángel; Kutsenko, Yevheniy; Barreda, Alberto; Ribeiro-Do-Couto, Bruno; Navarro-Mateu, Fernando; Ferrán, José-Luis (FRONTIERS MEDIA SA, 2021)
    Purpose: To identify and characterize numerically and topographically the population of alpha retinal ganglion cells (alpha RGCs) and their subtypes, the sustained-response ON-center alpha RGCs (ONs-alpha RGCs), which ...
  • A longitudinal Analysis of the Association between Socioeconomic Position and Multimorbidity in the European Prospective Investigation into Cancer and Nutrition Study 
    Manfredi, Luca; Sodano, Barbara; Raganato, Chiara; Buscema, Federica; Milani, Lorenzo; Catalano, Alberto; Freisling, Heinz; Ferrari, Pietro; Abraha, Alem; Kaaks, Rudolf; Katzke, Verena; Panico, Salvatore; Antoniussen, Christian-Skodt; Dahm, Christina-C; Tin, Sandar-Tin; Vermeulen, Roel; Vaartjes, Ilonca; Tjonneland, Anne; Olsen, Anja; Colorado-Yohar, Sandra; Grioni, Sara; Gunter, Marc-J; Schulze, Matthias-B; Córdova, Reynalda; Sánchez, María-José; Bonet-Bonet, Catalina; Tumino, Rosario; Mokoroa, Olatz; Masala, Giovanna; Guevara-Eslava, Marcela; Verschuren, Monique; Sacerdote, Carlotta; Ricceri, Fulvio (INT SOC AGING & DISEASE, 2024)
    The association between socioeconomic position (SEP) and non-communicable diseases (NCDs) is well established, but its role in driving multimorbidity remains unclear. Multimorbidity, defined as the co-occurrence of more ...
  • A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism 
    Nopp, Stephan; Spielvogel, Clemens; Bikdeli, Behnood; Alberich-Conesa, Ana; Hernández-Blasco, Luis; Peris, Ma-Luisa; Otero, Remedios; Jiménez, David; Monreal, Manuel; Ay, Cihan; Agudo-de-Blas, P; Aibar, J; Alberich-Conesa, Ana; Alda-Lozano, A; Alfonso, J; Alonso-Carrillo, J; Álvarez-Vega, P; Amado, C; Angelina-García, M; Arcelus, J-I; Ballaz, A; Barba, R; Barbagelata, C; Barron, M; Barron-Andres, B; Bascuñana, J; Blanco-Molina, A; Bustos-Carpio, J; Casado, I; Chasco, L; Claver, G; De-Juana-Izquierdo, C; Del-Toro, J; Demelo-Rodríguez, P; Díaz-Brasero, A-M; Díaz-Pedroche, M-C; Díaz-Peromingo, J-A; Dubois-Silva, A; Escribano, J-C; Fernández-Capitan, C; Fernández-Jiménez, B; Fernández-Reyes, J-L; Fidalgo, M-A; Francisco, I; Gabara, C; Galeano-Valle, F; García-Bragado, F; García-González, C; García-Ortega, A; Gavin-Sebastian, O; Gil-de-Gómez, M-A; Gil-Díaz, A; Gómez-Cepeda, C; Gómez-Cuervo, C; González-Martínez, J; González-Munera, A; Gorostidi, J; Grau, E; Guirado-Torrecillas, Leticia; Gutiérrez-Guisado, J; Hernández-Blasco, L; Jara-Palomares, L; Jiménez, D; Jou, I; Joya, M-D; Lainez-Justo, S; Lecumberri, R; Lobo, J-L; López-Jiménez, L; López-Miguel, P; López-Núñez, J-J; López-Ruiz, Alfonso; López-Sáez, J-B; Lorenzo, A; Madridano, O; Maestre, A; Marchena, P-J; Marcos, M; Martín-del-Pozo, M; Martin-Martos, Francisco; Maza, J-M; Mercado, M-I; Molino, A; Monreal, M; Monzon, L; Navas, M-S; Nieto, J-A; Núñez-Fernández, M-J; Ordieres, L; Ortiz, O; Otalora-Valderrama, Sonia; Otero, R; Pacheco-Gómez, N; Pagan, J; Parra-Caballero, P; Pedrajas, J-M; Pérez-Amoros, J; Pérez-Cabezas, A; Pérez-Ductor, C; Pérez-Pinar, M; Peris, M-L; Pesce, M-L; Porras, J-A; Puchades, R; Puche, G; Rivas, A; Rivera-Civico, F; Rodríguez-Cobo, A; Romero-Bruguera, M; Salgueiro, G; Sánchez-Juez, A; Sancho, T; Sendin, V; Siguenza, P; Soler, S; Sota-Yoldi, L-A; Suárez-Fernández, S; Tirado, R; Torrents-Vilar, A; Torres, M-I; Trujillo-Santos, Javier; Uresandi, F; Valle, R; Varona, J-F; Vázquez, E; Villalobos, A; Villarejo, C; Villares, P; Ay, C; Nopp, S; Pabinger, I; Vanassche, T; Verhamme, P; Verstraete, A; Rocha, A-T; Yoo, H-H-B; Montenegro, A-C; Morales, S-N; Roa, J; Hirmerova, J; Maly, R; Acassat, S; Bertoletti, L; Brehon, M; Bura-Riviere, A; Catella, J; Chopard, R; Couturaud, F; Espitia, O; Le-Mao, R; Leclercq, B; Mahe, I; Moustafa, F; Plaisance, L; Poenou, G; Quere, I; Sarlon-Bartoli, G; Suchon, P; Versini, E; Schellong, S; Rashidi, F; Sadeghipour, P; Tahmasbi, F; Brenner, B; Kennet, G; Tzoran, I; Barillari, G; Basaglia, M; Bilora, F; Bissacco, D; Brandolin, B; Casana, R; Ciammaichella, M-M; Colaizzo, D; Di-Micco, P; Giorgi-Pierfranceschi, M; Grandone, E; Lambertenghi-Deliliers, D; Marcon, C; Poz, A; Prandoni, P; Simioni, P; Siniscalchi, C; Taflaj, B; Tufano, A; Visona, A; Zalunardo, B; Skride, A; Tazi-Mezalek, Z; Fonseca, S; Marques, R; Meireles, J; Pinto, S; Bosevski, M; Zdraveska, M; Barco, S; Bounameaux, H; Keller, S; Mazzolai, L; Porceddu, E; Aujayeb, A; Angiolillo, D-J; Bikdeli, B; Caprini, J-A; Khalil, A; Ortega-Paz, L; Tafur, J; Weinberg, I; Bui, H-M (NATURE PORTFOLIO, 2025-09-24)
    Pulmonary embolism (PE) can result in long-term sequelae, such as post-PE syndrome, including persistent dyspnea and chronic thromboembolic pulmonary hypertension (CTEPH). Existing prediction tools for severe post-PE ...
  • A Multi-Locus Genetic Risk Score for Primary Open-Angle Glaucoma (POAG) Variants Is Associated with POAG Risk in a Mediterranean Population: Inverse Correlations with Plasma Vitamin C and E Concentrations 
    Zanon-Moreno, Vicente; Ortega-Azorín, Carolina; Asensio-Marquez, Eva-M; García-Medina, José-Javier; Pinazo-Duran, María-D; Coltell, Oscar; Ordovas, Jose-M; Corella, Dolores (MDPI AG, 2017-11)
    Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. The genetics of POAG are complex, and population-specific effects have been reported. Although many polymorphisms associated with POAG risk have ...
  • A new insight into the three-dimensional architecture of the Golgi complex: Characterization of unusual structures in epididymal principal cells 
    Martínez-Martínez, Narcisa; Martínez-Alonso, Emma; Tomas, Mónica; Neumueller, Josef; Pavelka, Margit; Martínez-Menarguez, José-A (PUBLIC LIBRARY SCIENCE, 2017-09-28)
    Principal epididymal cells have one of the largest and more developed Golgi complex of mammalian cells. In the present study, we have used this cell as model for the study of the three-dimensional architecture of the Golgi ...
  • A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity 
    Cuenca-Bermejo, Lorena; Pizzichini, Elisa; Goncalves, Valeria-C; Guillén-Díaz, María; Aguilar-Moñino, Elena; Sánchez-Rodrigo, Consuelo; González-Cuello, Ana-María; Fernández-Villalba, Emiliano; Herrero, María-Trinidad (MDPI, 2021-05)
    We report a neonatal patient with hypertrophic cardiomyopathy (HCM), lactic acidosis and isolated complex I deficiency. Using a customized next-generation sequencing panel, we identified a novel hemizygous variant c.338G>A ...
  • A Novel GATA1 Variant in the C-Terminal Zinc Finger Compared with the Platelet Phenotype of Patients with A Likely Pathogenic Variant in the N-Terminal Zinc Finger 
    Bastida, José-María; Malvestiti, Stefano; Boeckelmann, Doris; Palma-Barqueros, Verónica; Wolter, Mira; Lozano-Almela, María-Luisa; Glonnegger, Hannah; Benito, Rocío; Zaninetti, Carlo; Sobotta, Felix; Schilling, Freimut-H; Morgan, Neil-V; Freson, Kathleen; Rivera, José; Zieger, Barbara (MDPI, 2022-10)
    The GATA1 transcription factor is essential for normal erythropoiesis and megakaryocytic differentiation. Germline GATA1 pathogenic variants in the N-terminal zinc finger (N-ZF) are typically associated with X-linked ...
  • A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study 
    Papadimitriou, Nikos; Muller, David; van-den-Brandt, Piet-A; Geybels, Milan; Patel, Chirag-J; Gunter, Marc-J; López, David-S; Key, Timothy-J; Pérez-Cornago, Aurora; Ferrari, Pietro; Vineis, Paolo; Weiderpass, Elisabete; Boeing, Heiner; Agudo, Antonio; Sánchez, María-José; Overvad, Kim; Kuehn, Tilman; Fortner, Renee-T; Palli, Domenico; Drake, Isabel; Bjartell, Anders; Santiuste-de-Pablos, Carmen; Bueno-de-Mesquita, Bas; Krogh, Vittorio; Tjonneland, Anne; Lauritzen, Dorthe-Furstrand; Barricarte-Gurrea, Aurelio; Quirós, José-Ramón; Stattin, Par; Trichopoulou, Antonia; Martimianaki, Georgia; Karakatsani, Anna; Thysell, Elin; Johansson, Ingegerd; Ricceri, Fulvio; Tumino, Rosario; Larranaga, Nerea; Khaw, Kay-Tee; Riboli, Elio; Tzoulaki, Ioanna; Tsilidis, Konstantinos-K (SPRINGER HEIDELBERG, 2020-10)
    PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. METHODS: A nutrient-wide association study was conducted to systematically and comprehensively ...