Aguila, Sonia; Izaguirre, Gonzalo; Martínez-Martínez, Irene; Vicente, Vicente; Olson, Steven-T; Corral, Javier
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017-10-06)
Antithrombin mainly inhibits factor Xa and thrombin. The reactive center loop (RCL) is crucial for its interactions with its protease targets and is fully inserted into the A-sheet after its cleavage, causing translocation ...