Repositorio Dspace

Listar por tema "Calcium/metabolism"

Listar por tema "Calcium/metabolism"

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  • Doxorubicin-induced oxidative stress: The protective effect of nicorandil on HL-1 cardiomyocytes 
    Asensio-López, María-del-Carmen; Soler, Fernando; Pascual-Figal, Domingo-Andrés; Fernández-Belda, Francisco; Lax, Antonio (PUBLIC LIBRARY SCIENCE, 2017-02-28)
    The primary cardiotoxic action of doxorubicin when used as antitumor drug is attributed to the generation of reactive oxygen species (ROS) therefore effective cardioprotection therapies are needed. In this sense, the ...
  • SARAF overexpression impairs thrombin-induced Ca2+ homeostasis in neonatal platelets 
    Berna-Erro, Alejandro; Granados, María-P; Teruel-Montoya, Raúl; Ferrer-Marín, Francisca; Delgado, Elena; Corbacho, Antonio-J; Fenandez, Esperanza; Vázquez-Godoy, María-T; Tapia, José-A; Redondo, Pedro-Cosme (WILEY, 2024-03)
    Neonatal platelets present a reduced response to the platelet agonist, thrombin (Thr), thus resulting in a deficient Thr-induced aggregation. These alterations are more pronounced in premature newborns. Here, our aim was ...
  • STIMATE-Mustn1 Fusion Protein Prevents Ca2+Overload in Cells That Present Increased SOCE. 
    Berna-Erro, Alejandro; Camello, Pedro-J; Granados, María-P; Delgado, Elena; Fernández, Esperanza; Teruel-Montoya, Raúl; Ferrer-Marín, Francisca; Rosado, Juan-A; Redondo, Pedro-C (OXFORD UNIV PRESS, 46081)
    Store operated Ca(2+) entry (SOCE) is altered in neonatal platelets with respect to adult platelets. Here, we aim to analyze the changes in STIMATE translation that leads to generating STIMATE-mustn1 and its possible ...
  • Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation, and transcriptional regulation as human S100 proteins 
    Hernández, Liz; Paris, Theo; Demou, María; Birck, Catherine; Begon-pescia, Christina; Rodríguez-Vidal, Juan-Francisco; Tyrkalska, Sylwia-D; Bureau, Charlotte; González, Catherine; Gracia, Juliette; Lelievre, Etienne; Mulero, Victoriano; Nguyen-chi, Mai; Yatime, Laure (WILEY, 2026-04)
    S100 proteins are highly versatile calcium-binding proteins from vertebrates. Following extracellular release, they become essential in immune and antimicrobial defenses, initiating the inflammatory response through receptor ...
  • The PI3Kd Inhibitor Idelalisib Diminishes Platelet Function and Shows Antithrombotic Potential 
    Barrachina, María-N; Izquierdo, Irene; Hermida-Nogueira, Lidia; Morán, Luis-A; Pérez, Amparo; Arroyo, Ana-B; García-Barbera, Nuria; González-Conejero, Rocío; Troitino, Sara; Eble, Johannes-A; Rivera, José; Martínez, Constantino; Loza, María-I; Domínguez, Eduardo; García, Ángel (MDPI, 2021-04)
    BACKGROUND: Clinical management of ischemic events and prevention of vascular disease is based on antiplatelet drugs. Given the relevance of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) as a candidate target in ...
  • The Sarcoplasmic/Endoplasmic reticulum Ca2+-ATPase (SERCA) is present in pig sperm and modulates their physiology over liquid preservation 
    Garriga, Ferran; Martínez-Hernández, Jesús; Parra-Balaguer, Ainhoa; Llavanera, Marc; Yeste, Marc (NATURE PORTFOLIO, 2025-02-04)
    Liquid storage is the primary preservation method in the swine breeding industry because of its advantages over cryopreservation. Calcium (Ca(2+)), a key regulator of cell physiology, plays a crucial role during liquid ...