Repositorio Dspace

Listar por autor "Iacobelli, Massimo"

Listar por autor "Iacobelli, Massimo"

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  • Defibrotide for Protecting Against and Managing Endothelial Injury in Hematologic Malignancies and COVID-19 
    Richardson, Edward; Mo, Clifton-C; Calabretta, ELeónora; Corrado, Francesco; Kocoglu, Mehmet-H; Baron, Rebecca-M; Connors, Jean-Marie; Iacobelli, Massimo; Wei, Lee-Jen; Benjamin, Emily-J; Rapoport, Aaron-P; Díaz-Ricart, Maribel; Martínez-Mellado, Antonio-José; Carlo-Stella, Carmelo; Richardson, Paul-G; Moraleda-Jiménez, José-María (MDPI, 2025-07-14)
    Defibrotide, which is approved for treating hepatic veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS), exhibits pleiotropic anti-inflammatory, anti-thrombotic, and fibrinolytic properties, conferring broad ...
  • Endothelial dysfunction and its critical role in COVID-19-associated coagulopathy: Defibrotide as an endothelium-protective, targeted therapy 
    García-Bernal, David; Richardson, Edward; Vlodavsky, Israel; Carlo-Stella, Carmelo; Iacobelli, Massimo; Jara, Rubén; Richardson, Paul-G; Moraleda-Jiménez, José-María (Wiley, 2021-08)
    INTRODUCTION: The increase in the number of patients with hemoglobinopathies in Europe in recent decades highlights the need for more detailed epidemiological information in Spain. To fulfil this need, the Spanish Society ...
  • Endothelial injury and dysfunction with emerging immunotherapies in multiple myeloma, the impact of COVID-19, and endothelial protection with a focus on the evolving role of defibrotide 
    Mo, Clifton-C; Richardson, Edward; Calabretta, Eleonora; Corrado, Francesco; Kocoglu, Mehmet-H; Baron, Rebecca-M; Connors, Jean-Marie; Iacobelli, Massimo; Wei, Lee-Jen; Rapoport, Aaron-P; Díaz-Ricart, Maribel; Moraleda-Jiménez, José-María; Carlo-Stella, Carmelo; Richardson, Paul-G (CHURCHILL LIVINGSTONE, 2024-07)
    Patients with multiple myeloma (MM) were among the groups impacted more severely by the COVID-19 pandemic, with higher rates of severe disease and COVID-19-related mortality. MM and COVID-19, plus post-acute sequelae of ...
  • Phase IIB, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID-19 
    Jara-Rubio, Rubén; Martínez-Mellado, Antonio-José; Kiwitt-Cardenas, Jonathan; Clavel, José-G; García-Pérez, Bartolomé; Castro, Pedro; Díaz-Ricart, Maribel; Carrillo-Alcaraz, Andrés; López-Bernus, Amparo; Bernal-Morell, Enrique; Roura, Aychel; Marín, Sonia; Ruiz-López, Francisco-José; Solana-Martínez, Elena; Martínez-Baño, Domingo; Albacete-Moreno, Carlos-L; Andreu-Soler, Enriqueta; Tellez-Santoyo, Adrián; Fernández-Méndez, Sara; Noguera-Velasco, José-Antonio; Cebreiros-López, Iria; Parrilla, Andrés; Espuny-Miró, Alberto; García-Bernal, David; Blanquer-Blanquer, Miguel; Sánchez-Salinas, Andrés; Iniesta-Martínez, Francisca; Hernández-García, Cristina; Muro-Amador, Manuel; Minguela-Puras, Alfredo; Moreno-Docón, Antonio; Torres-Cantero, Alberto; Muñoz-García, María; Serrano, Manuel; Iacobelli, Massimo; Carlo-Stella, Carmelo; Wei, Lee-Jen; Richardson, Paul-G; Moraleda-Jiménez, José-María (WILEY, 2026-05-12)
    INTRODUCTION: Endothelial dysfunction is key in COVID-19 pathogenesis. This randomized, double-blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS-CoV-2 ...