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Listar01. Consejería de Salud por tema "Adult"

Listar01. Consejería de Salud por tema "Adult"

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  • A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes: Integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct case-cohort study 
    Sobiecki, Jakub-G-D; Imamura, Fumiaki; Davis, Courtney-R; Sharp, Stephen-J; Koulman, Albert; Hodgson, Jonathan-M; Guevara, Marcela; Schulze, Matthias-B; Zheng, Ju-Sheng; Agnoli, Claudia; Bonet, Catalina; Colorado-Yohar, Sandra-Milena; Fagherazzi, Guy; Franks, Paul-W; Gunder, (PUBLIC LIBRARY SCIENCE, 2023-04)
    BackgroundSelf-reported adherence to the Mediterranean diet has been modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this ...
  • Adherence to the Mediterranean Diet and Obesity-Linked Cancer Risk in EPIC 
    Aguilera-Buenosvinos, Inmaculada; Morales-Berstein, Fernanda; González-Gil, Esther-M; Dossus, Laure; Gunter, Marc-J; Biessy, Carine; Masala, Giovanna; Santucci-de-Magistris, María; Laouali, Nasser; Shah, Sanam; Marques, Chloe; Heath, Alicia-K; Tsilidis, Konstantinos-K; Cross, Amanda-J; Ferrari, Pietro; Castro-Espín, Carlota; Debras, Charlotte; Tumino, Rosario; Tjonneland, Anne; Halkjaer, Jytte; Drake, Isabel; Ericson, Ulrika; Guevara, Marcela; Rodríguez-Barranco, Miguel; Skeie, Guri; Braaten, Tonje; Gram, Inger-Torhild; Dahm, Christina-C; Agnoli, Claudia; Schulze, Matthias-B; Huerta-Castaño, José-María; Martínez-González, Miguel-Ángel; Huybrechts, Inge; Toledo-Atucha, Estefanía (AMER MEDICAL ASSOC, 2025-02-25)
    IMPORTANCE: Adherence to the Mediterranean Diet (MedDiet) has been associated with a lower incidence of cancer and reduced weight gain. These associations suggest a potential role for the MedDiet in lowering the risk of ...
  • Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study 
    Dossus, Laure; Franceschi, Silvia; Biessy, Carine; Navionis, Anne-Sophie; Travis, Ruth-C; Weiderpass, Elisabete; Scalbert, Augustin; Romieu, Isabelle; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie-Christine; Bonnet, Fabrice; Fournier, Agnes; Fortner, Renee-T; Kaaks, Rudolf; Aleksandrova, Krasimira; Trichopoulou, Antonia; La-Vecchia, Carlo; Peppa, Eleni; Tumino, Rosario; Panico, Salvatore; Palli, Domenico; Agnoli, Claudia; Vineis, Paolo; Bueno-de-Mesquita, Bas; Peeters, Petra-H; Skeie, Guri; Zamora-Ros, Raul; Chirlaque-López, María-Dolores; Ardanaz, Eva; Sánchez, María-José; Quirós, J-Ramón; Dorronsoro, Miren; Sandstrom, María; Nilsson, Lena-María; Schmidt, Julie-A; Khaw, Kay-Tee; Tsilidis, Konstantinos-K; Aune, Dagfinn; Riboli, Elio; Rinaldi, Sabina (WILEY, 2018-04-01)
    Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence ...
  • Agreement among Mediterranean Diet Pattern Adherence Indexes: MCC-Spain Study 
    Olmedo-Requena, Rocío; González-Donquiles, Carmen; Davila-Batista, Veronica; Romaguera, Dora; Castello, Adela; Molina-de-la-Torre, Antonio-Jose; Amiano, Pilar; Dierssen-Sotos, Trinidad; Guevara, Marcela; Fernández-Tardon, Guillermo; Lozano-Lorca, Macarena; Alguacil, Juan; Peiro, Rosana; Huerta-Castaño, José-María; Gracia-Lavedan, Esther; Aragones, Nuria; Fernández-Villa, Tania; Solans, Marta; Gómez-Acebo, Ines; Castaño-Vinyals, Gemma; Kogevinas, Manolis; Pollan, Marina; Martín, Vicente (MDPI, 2019-02-26)
    There are many different methods used to measure the degree of adherence to a Mediterranean diet (MD), limiting comparison and interpretation of their results. The concordance between different methodologies has been ...
  • ALG12-CDG: An unusual patient without intellectual disability and facial dysmorphism, and with a novel variant 
    de-la-Morena-Barrio, María-Eugenia; Sabater-Molina, María; de-la-Morena-Barrio, Belén; Ruhaak, Renee-L; Miñano, Antonia; Padilla, José; Toderici, Mara; Roldán-Schilling, Vanessa; Gimeno-Blanes, Juan-Ramón; Vicente, Vicente; Corral, Javier (WILEY, 2020-08)
    BACKGROUND: Congenital disorder of glycosylation (CDG) type I is a group of rare disorders caused by recessive mutations in up to 25 genes that impair the N-glycan precursor formation and its transfer to proteins resulting ...
  • Anti-Mullerian hormone and endometrial cancer: a multi-cohort study 
    Fortner, Renee-T; Schock, Helena; Jung, Seungyoun; Allen, Naomi-E; Arslan, Alan-A; Brinton, Louise-A; Egleston, Brian-L; Falk, Roni-T; Gunter, Marc-J; Helzlsouer, Kathy-J; Idahl, Annika; Johnson, Theron-S; Kaaks, Rudolf; Krogh, Vittorio; Lundin, Eva; Merritt, Melissa-A; Navarro, Carmen; Onland-Moret, N-Charlotte; Palli, Domenico; Shu, Xiao-Ou; Sluss, Patrick-M; Staats, Paul-N; Trichopoulou, Antonia; Weiderpass, Elisabete; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Dorgan, Joanne-F (SPRINGERNATURE, 2017-10)
    BACKGROUND: The Mullerian ducts are the embryological precursors of the female reproductive tract, including the uterus; anti-Mullerian hormone (AMH) has a key role in the regulation of foetal sexual differentiation. ...
  • Antibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal cancer 
    Butt, Julia; Fernández-de-Larrea, Nerea; Tjalsma, Harold; Roelofs, Rian; Kato, Ikuko; Martín, Vicente; Pérez-Gómez, Beatriz; Moreno, Víctor; Dierssen-Sotos, Trinidad; Castilla, Jess; Fernández-Tardon, Guillermo; Amiano, Pilar; Salas, Dolores; Alguacil, Juan; Juan-Jiménez-Moleon, José; Huerta-Castaño, José-María; de-Sanjose, Silvia; del-Campo, Rosa; Kogevinas, Manolis; Pollan, Marina; Pawlita, Michael; Waterboer, Tim; Boleij, Annemarie; Aragonés, Nuria (NATURE PORTFOLIO, 2019-07-26)
    Antibodies to Streptococcus gallolyticus subspecies gallolyticus (SGG) have been associated with colorectal cancer (CRC). Because SGG may correlate with impaired gut epithelia, we assessed the association of antibodies to ...
  • Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition 
    Park, Jin-Young; Van-Puyvelde, Heleen; Regazzetti, Lea; Clasen, Joanna-L; Heath, Alicia-K; Eussen, Simone; Ueland, Per-Magne; Johansson, Mattias; Biessy, Carine; Zamora-Ros, Raúl; Huerta-Castaño, José-María; Sánchez, María-José; Ocke, Marga; Schulze, Matthias-B; Schiborn, Catarina; Braaten, Tonje-Bjorndal; Skeie, Guri; Sacerdote, Carlotta; Castilla, Jesús; Karlsson, Therese; Johansson, Ingegerd; Kyro, Cecilie; Tjonneland, Anne; Tong, Tammy-Y-N; Katzke, Verena; Bajracharya, Rashmita; Lasheras, Cristina; Midttun, Oivind; Vollset, Stein-Emil; Vineis, Paolo; Masala, Giovanna; Amiano, Pilar; Tumino, Rosario; Baldassari, Iván; Weiderpass, Elisabete; Riboli, Elio; Gunter, Marc-J; Freisling, Heinz; Rinaldi, Sabina; Muller, David-C; Huybrechts, Inge; Ferrari, Pietro (MDPI, 2025-06-10)
    Background/Objectives: We examined the association between dietary intake and blood concentrations of one-carbon metabolism (OCM)-related nutrients in the European Prospective Investigation into Cancer and Nutrition (EPIC). ...
  • Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study 
    Baumeister, Sebastian-E; Schlesinger, Sabrina; Aleksandrova, Krasimira; Jochem, Carmen; Jenab, Mazda; Gunter, Marc-J; Overvad, Kim; Tjonneland, Anne; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Fournier, Agnes; Kuehn, Tilman; Kaaks, Rudolf; Pischon, Tobias; Boeing, Heiner; Trichopoulou, Antonia; Bamia, Christina; La-Vecchia, Carlo; Masala, Giovanna; Panico, Salvatore; Fasanelli, Francesca; Tumino, Rosario; Grioni, Sara; Bueno-de-Mesquita, Bas; Vermeulen, Roel; May, Anne-M; Borch, Kristin-B; Oyeyemi, Sunday-O; Ardanaz, Eva; Rodríguez-Barranco, Miguel; Chirlaque-López, María-Dolores; Felez-Nobrega, Mireia; Sonestedt, Emily; Ohlsson, Bodil; Hemmingsson, Oskar; Werner, Marten; Pérez-Cornago, Aurora; Ferrari, Pietro; Stepien, Magdalena; Freisling, Heinz; Tsilidis, Konstantinos-K; Ward, Heather; Riboli, Elio; Weiderpass, Elisabete; Leitzmann, Michael-F (ELSEVIER, 2019-05)
    BACKGROUND & AIMS: To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer ...
  • Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study 
    Zheng, Ju-Sheng; Sharp, Stephen-J; Imamura, Fumiaki; Koulman, Albert; Schulze, Matthias-B; Ye, Zheng; Griffin, Jules; Guevara, Marcela; Huerta-Castaño, José-María; Kroeger, Janine; Sluijs, Ivonne; Agudo, Antonio; Barricarte, Aurelio; Boeing, Heiner; Colorado-Yohar, Sandra; Dow, Courtney; Dorronsoro, Miren; Dinesen, Pia-T; Fagherazzi, Guy; Franks, Paul-W; Feskens, Edith-J-M; Kuehn, Tilman; Katzke, Verena-Andrea; Key, Timothy-J; Khaw, Kay-Tee; de-Magistris, María-Santucci; Romana-Mancini, Francesca; Molina-Portillo, Elena; Nilsson, Peter-M; Olsen, Anja; Overvad, Kim; Palli, Domenico; Quirós, J-Ramón; Rolandsson, Olov; Ricceri, Fulvio; Spijkerman, Annemieke-M-W; Slimani, Nadia; Tagliabue, Giovanna; Tjonneland, Anne; Tumino, Rosario; van-der-Schouw, Yvonne-T; Langenberg, Claudia; Riboli, Elio; Forouhi, Nita-G; Wareham, Nicholas-J (BMC, 2017-11-17)
    BACKGROUND: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with ...
  • Association of menopausal characteristics and risk of coronary heart disease: a pan-European case-cohort analysis 
    Dam, Veerle; van-Der-Schouw, Yvonne-T; Onland-Moret, N-Charlotte; Groenwold, Rolf-H-H; Peters, Sanne-A-E; Burgess, Stephen; Wood, Ángela-M; Chirlaque-López, María-Dolores; Moons, Karel-G-M; Oliver-Williams, Clare; Schuit, Ewoud; Tikk, Kaja; Weiderpass, Elisabete; Holm, Marianne; Tjonneland, Anne; Kuehn, Tilman; Fortner, Renee-T; Trichopoulou, Antonia; Karakatsani, Anna; La-Vecchia, Carlo; Ferrari, Pietro; Gunter, Marc; Masala, Giovanna; Sieri, Sabina; Tumino, Rosario; Panico, Salvatore; Boer, Jolanda-M-A; Verschuren, W-M-Monique; Salamanca-Fernández, Elena; Arriola, Larraitz; Moreno-Iribas, Conchi; Engstrom, Gunnar; Melander, Olle; Nordendahl, María; Wennberg, Patrik; Key, Timothy-J; Colorado-Yohar, Sandra; Matullo, Giuseppe; Overvad, Kim; Clavel-Chapelon, Francoise; Boeing, Heiner; Quirós, J-Ramón; di-Ángelantonio, Emanuele; Langenberg, Claudia; Sweeting, Michael-J; Riboli, Elio; Wareham, Nicholas-J; Danesh, John; Butterworth, Adam (OXFORD UNIV PRESS, 2019-08)
    BACKGROUND: Earlier age at menopause has been associated with increased risk of coronary heart disease (CHD), but the shape of association and role of established cardiovascular risk factors remain unclear. Therefore, we ...
  • Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes: EPIC-InterAct Case-Cohort Study 
    Zheng, Ju-Sheng; Imamura, Fumiaki; Sharp, Stephen-J; van-der-Schouw, Yvonne-T; Sluijs, Ivonne; Gundersen, Thomas-E; Ardanaz, Eva; Boeing, Heiner; Bonet, Catalina; Humberto-Gómez, Jesús; Dow, Courtney; Fagherazzi, Guy; Franks, Paul-W; Jenab, Mazda; Kuehn, Tilman; Kaaks, Rudolf; Key, Timothy-J; Khaw, Kay-Tee; Lasheras, Cristina; Mokoroa, Olatz; Mancini, Francesca-Romana; Nilsson, Peter-M; Overvad, Kim; Panico, Salvatore; Palli, Domenico; Rolandsson, Olov; Sieri, Sabina; Salamanca-Fernández, Elena; Sacerdote, Carlotta; Spijkerman, Annemieke-M-W; Stepien, Magdalena; Tjonneland, Anne; Tumino, Rosario; Butterworth, Adam-S; Riboli, Elio; Danesh, John; Langenberg, Claudia; Forouhi, Nita-G; Wareham, Nicholas-J (ENDOCRINE SOC, 2019-04)
    BACKGROUND: Existing evidence for the prospective association of vitamin D status with type 2 diabetes (T2D) is focused almost exclusively on circulating total 25-hydroxyvitamin D [25(OH)D] without distinction between its ...
  • Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort 
    Butt, Julia; Jenab, Mazda; Werner, Jill; Fedirko, Veronika; Weiderpass, Elisabete; Dahm, Christina-C; Tjonneland, Anne; Olsen, Anja; Boutron-Ruault, Marie-Christine; Rothwell, Joseph-A; Severi, Gianluca; Kaaks, Rudolf; Turzanski-Fortner, Renee; Aleksandrova, Krasimira; Schulze, Matthias-B; Palli, Domenico; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, Bas; Van-Gils, Carla-H; Gram, Inger-Torhild; Lukic, Marko; Sala, Nuria; Sánchez-Pérez, María-José; Ardanaz, Eva; Chirlaque-López, María-Dolores; Palmquist, Richard; Lowenmark, Thyra; Travis, Ruth-C; Heath, Alicia-K; Cross, Amanda-J; Freisling, Heinz; Zouiouich, Semi; Aglago, Elom-K; Waterboer, Tim; Hughes, David-J (TAYLOR & FRANCIS INC, 2021-01-01)
    Experimental evidence has implicated genotoxic Escherichia coli (E. coli) and enterotoxigenic Bacteroides fragilis (ETBF) in the development of colorectal cancer (CRC). However, evidence from epidemiological studies is ...
  • Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status 
    Fedirko, Veronika; Jenab, Mazda; Meplan, Catherine; Jones, Jeb-S; Zhu, Wanzhe; Schomburg, Lutz; Siddiq, Afshan; Hybsier, Sandra; Overvad, Kim; Tjonneland, Anne; Omichessan, Hanane; Perduca, Vittorio; Boutron-Ruault, Marie-Christine; Kuehn, Tilman; Katzke, Verena; Aleksandrova, Krasimira; Trichopoulou, Antonia; Karakatsani, Anna; Kotanidou, Anastasia; Tumino, Rosario; Panico, Salvatore; Masala, Giovanna; Agnoli, Claudia; Naccarati, Alessio; Bueno-de-Mesquita, Bas; Vermeulen, Roel-C-H; Weiderpass, Elisabete; Skeie, Guri; Nost, Therese-Haugdahl; Lujan-Barroso, Leila; Quirós, José-Ramón; Huerta-Castaño, José-María; Rodríguez-Barranco, Miguel; Barricarte-Gurrea, Aurelio; Gylling, Bjoern; Harlid, Sophia; Bradbury, Kathryn-E; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc; Murphy, Neil; Freisling, Heinz; Tsilidis, Kostas; Aune, Dagfinn; Riboli, Elio; Hesketh, John-E; Hughes, David-J (MDPI, 2019-04)
    Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide ...
  • Associations of milk, dairy products, calcium and vitamin D intake with risk of developing Parkinson¿s disease within the EPIC4ND cohort 
    Groeninger, Mareike; Sabin, Jara; Kaaks, Rudolf; Amiano, Pilar; Aune, Dagfinn; Cabrera-Castro, Natalia; Guevara, Marcela; Hansen, Johnni; Homann, Jan; Masala, Giovanna; Nicolás, Genevieve; Peters, Susan; Sacerdote, Carlotta; Sánchez, María-José; De-Magistris, María-Santucci; Sieri, Sabina; Vermeulen, Roel; Zhao, Yujia; Lill, Christina-M; Katzke, Verena-A (Springer, 2024-11)
    Literature indicates a potential association between dairy consumption and risk of Parkinson´s disease (PD), especially among men, yet the results remain inconclusive. We investigated this association in a large prospective ...
  • Autoimmunity plays a role in the onset of diabetes after 40 years of age 
    Rolandsson, Olov; Hampe, Christiane-S; Sharp, Stephen-J; Ardanaz, Eva; Boeing, Heiner; Fagherazzi, Guy; Mancini, Francesca-Romana; Nilsson, Peter-M; Overvad, Kim; Chirlaque-López, María-Dolores; Dorronsoro, Miren; Gunter, Marc-J; Kaaks, Rudolf; Key, Timothy-J; Khaw, Kay-Tee; Krogh, Vittorio; Kuehn, Tilman; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Sánchez, María-José; Severi, Gianluca; Spijkerman, Annemieke-MW; Tumino, Rosario; van-der-Schouw, Yvonne-T; Riboli, Elio; Forouhi, Nita-G; Langenberg, Claudia; Wareham, Nicholas-J (SPRINGER, 2020-02)
    AIMS/HYPOTHESIS: Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of ...
  • Benefits of a community physical exercise program prescribed from primary care for perimenopausal/menopausal women 
    Alegria-Avilés-Martínez, María; López-Román, Francisco-Javier; Galiana-Gómez-de-Cadiz, María-José; Arnau-Sánchez, José; Martínez-Ros, María-Teresa; Lourdes-Fernández-López, María; García-Sánchez, Esther; Menárguez-Puche, Juan-Francisco (EDICIONES DOYMA S A, 2022-01)
    OBJECTIVE: To measure the benefits of a physical exercise program in a community, through the modifications in quality of life, and perimenopausal-menopausal women physical condition. SETTING: The participants were recruited ...
  • Blood Metal Levels and Amyotrophic Lateral Sclerosis Risk: A Prospective Cohort 
    Peters, Susan; Broberg, Karin; Gallo, Valentina; Levi, Michael; Kippler, María; Vineis, Paolo; Veldink, Jan; van-den-Berg, Leonard; Middleton, Lefkos; Travis, Ruth-C; Bergmann, Manuela-M; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Elbaz, Alexis; Vlaar, Tim; Mancini, Francesca-Romana; Kuehn, Tilman; Katzke, Verena-A; Agudo, Antonio; Goni, Fernando; Gómez-Gómez, Jesús-Humberto; Rodríguez-Barranco, Miguel; Merino, Susana; Barricarte-Gurrea, Aurelio; Trichopoulou, Antonia; Jenab, Mazda; Weiderpass, Elisabete; Vermeulen, Roel (Wiley, 2021-01)
    OBJECTIVE: Metals have been suggested as a risk factor for amyotrophic lateral sclerosis (ALS), but only retrospective studies are available to date. We compared metal levels in prospectively collected blood samples from ...
  • Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study 
    Mariosa, Daniela; Smith-Byrne, Karl; Richardson, Tom-G; Ferrari, Pietro; Gunter, Marc-J; Papadimitriou, Nikos; Murphy, Neil; Christakoudi, Sofia; Tsilidis, Konstantinos-K; Riboli, Elio; Muller, David; Purdue, Mark-P; Chanock, Stephen-J; Hung, Rayjean-J; Amos, Christopher; O'Mara, Tracy-A; Amiano, Pilar; Pasanisi, Fabrizio; Rodríguez-Barranco, Miguel; Krogh, Vittorio; Tjonneland, Anne; Halkjaer, Jytte; Pérez-Cornago, Aurora; Chirlaque-López, María-Dolores; Skeie, Guri; Rylander, Charlotta; Borch, Kristin-Benjaminsen; Aune, Dagfinn; Heath, Alicia-K; Ward, Heather; Schulze, Matthias-B; Bonet, Catalina; Weiderpass, Elisabete; Smith, George-Davey; Brennan, Paul; Johansson, Mattias (OXFORD UNIV PRESS INC, 2022-09)
    It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) ...
  • Breakfast Size and Prevalence of Metabolic Syndrome in the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish Cohort 
    Luján-Barroso, Leila; Iglesias, Lucía; Zamora-Ros, Raúl; Lasheras, Cristina; Sánchez, María-José; Cabrera-Castro, Natalia; Delfrade-Osinaga, Josu; Amiano, Pilar; Molina-Montes, Esther; Colorado-Yohar, Sandra-Milena; Moreno-Iribas, Conchi; Dorronsoro, Ane; Rodríguez-Barranco, Miguel; Chirlaque-López, María-Dolores; Aizpurua, Amaia; Agudo, Antonio; Quirós, José-Ramón; Jakszyn, Paula (MDPI, 2023-02)
    BACKGROUND: Recent evidence suggest that energy distribution during the daytimecould be a potential determinant for the development of metabolic syndrome (MetS). OBJECTIVE: To cross-sectionally assess the association between ...

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