02.07. Área de Salud VII Murcia Este

Tumores mesenquimales de intestino delgado: descripción de dos casos inusuales

Fri, 01 Jul 2016 00:00:00 GMT

Tumores mesenquimales de intestino delgado: descripción de dos casos inusuales Martínez-Sanz, Nuria; Ruiz-Marín, Miguel; González-Valverde, Francisco-Miguel; Sánchez-Cifuentes, Ángela; Fernández-López, Antonio-José; Ródenas-Moncada, Francisco-Javier; Albarracín-Marín-Blázquez, Antonio Presentamos dos casos de GIST intestinal ileales que debutaron con signos de complicación inespecífica y requirieron ser intervenidos de forma urgente, aportando imágenes inusuales de los tumores dadas sus características.

Pseudoquiste pancreático de localización intrahepática

Wed, 01 Apr 2015 00:00:00 GMT

Pseudoquiste pancreático de localización intrahepática Martínez-Sanz, Nuria; González-Valverde, Francisco-Miguel; Vicente-Ruiz, María; Pastor-Pérez, Patricia; Ruiz-Marín, Miguel; Albarracín-Marín-Blázquez, Antonio

Implication of Hepsin from Primary Tumor in the Prognosis of Colorectal Cancer Patients

Wed, 01 Jan 0010 00:00:00 GMT

Implication of Hepsin from Primary Tumor in the Prognosis of Colorectal Cancer Patients Zaragoza-Huesca, David; Nieto-Olivares, Andres; Garcia-Molina, Francisco; Ricote, Guillermo; Montenegro, Sofia; Sánchez-Canovas, Manuel; Garrido-Rodríguez, Pedro; Penas-Martínez, Julia; Vicente, Vicente; Martínez, Francisco; Lozano, Maria-Luisa; Carmona-B Hepsin is a type II transmembrane serine protease whose deregulation promotes tumor invasion by proteolysis of the pericellular components. In colorectal cancer, the implication of hepsin is unknown. Consequently, we aimed to study the correlations between hepsin expression and different clinical-histopathological variables in 169 patients with localized colorectal cancer and 118 with metastases. Tissue microarrays were produced from samples at diagnosis of primary tumors and stained with an anti-hepsin antibody. Hepsin expression was correlated with clinical-histopathological variables by using the chi-square and Kruskal?Wallis tests, Kaplan?Meier and Aalen?Johansen estimators, and Cox and Fine and Gray multivariate models. In localized cancer patients, high-intensity hepsin staining was associated with reduced 5-year disease-free survival (p-value = 0.16). Medium and high intensity of hepsin expression versus low expression was associated with an increased risk of metastatic relapse (hazard ratio 2.83, p-value = 0.035 and hazard ratio 3.30, p-value = 0.012, respectively), being a better prognostic factor than classic histological variables. Additionally, in patients with localized tumor, 5-year thrombosis cumulative incidence increased with the increment of hepsin expression (p-value = 0.038). Medium and high intensities of hepsin with respect to low intensity were associated with an increase in thrombotic risk (hazard ratio 7.71, p-value = 0.043 and hazard ratio 9.02, p-value = 0.028, respectively). This relationship was independent of previous tumor relapse (p-value = 0.036). Among metastatic patients, low hepsin expression was associated with a low degree of tumor differentiation (p-value < 0.001) and with major metastatic dissemination (p-value = 0.023). Hepsin is a potential thrombotic and metastatic biomarker in patients with localized colorectal cancer. In metastatic patients, hepsin behaves in a paradoxical way with respect to differentiation and invasion processes

Workflow for microbiological diagnosis of bacterial gastroenteritis combining a molecular assay as first-line with reflective stool culture

Wed, 01 Jan 0010 00:00:00 GMT

Workflow for microbiological diagnosis of bacterial gastroenteritis combining a molecular assay as first-line with reflective stool culture Muñoz-Davila, Maria-Jose; Candel-Pérez, C; Vicente, MR; Piqueras, M; Artero, JM