https://sms.carm.es/ricsmur/handle/123456789/17084 Fri, 17 Apr 2026 01:39:11 GMT 2026-04-17T01:39:11Z https://sms.carm.es/ricsmur/handle/123456789/25826 The Spanish Polygenic Score reference distribution: a resource for personalized medicine Carmona, Rosario; Roldán, Gema; Fernández-Rueda, José L; Navarro, Arcadi; Peña-Chilet, María; Surrallés, Jordi; Rosell, Jordi; Ribes, Antonia; Lopez, Esther; Ramos, Feliciano; Pujol, Aurora; Perona, Rosario; Perez, Belén; Palau, Francesc; Nunes, Virginia; García, Diana; Mulero, Victoriano; Morte, Beatriz; Fernández-Cancio, Mónica; Moreno-Galdó, Antonio; Morin, Matías; Moreno, Miguel Ángel; Millán, José Mª; Rovira, Eulalia; Martí, Ramón; Gallego-Martinez, Alvaro; Lopez-Escámez, Jose Antonio; Lapunzina, Pablo; Guillén, Encarnación; Grinberg, Daniel; Espinos, Carmina; Delmiro, Aitor; Tejada, Isabel; Castaño, Luis Antonio; Amigo, Jorge; Carracedo, Angel; Antiñolo, Guillermo; Borrego, Salud; Artuch, Rafael; Corton, Marta; Avila-Fernandez, Almudena; Minguez, Pablo; Ayuso, Carmen; Bostelmann, Gerrit; Perez-Florido, Javier; Aquino, Virginia; Pasalodos-Sanchez, Sara; Salgado-Garrido, Josefa; Alonso, Angel; Dopazo, Joaquín; López-López, Daniel Here we present the Polygenic Score (PGS) distributions for 3124 common diseases and quantitative traits observed in the Spanish population. To achieve so, the genomes and exomes of 2190 unrelated individuals of Spanish ancestry were used. The analysis covered a wide range of diseases and traits, including both complex disorders, such as various types of cancer, and disorders associated with the digestive, cardiovascular, neuronal, and immune systems, as well as quantitative traits like hematological and anthropometric measurements. The resulting PGS distributions provide valuable insights into the genetic architecture of the Spanish population, offering a comprehensive framework for investigating disease susceptibility and potential risk factors in this specific population. The study has also explored potential relationships between diseases and traits based on PGS pairwise correlations, revealing significant correlations that warrant further investigation. These findings have contributed to increase our understanding of the genetic basis of human traits and have implications for personalized medicine and public health interventions in the Spanish population. In addition, for the sake of reproducibility, we provide a data processing pipeline, enabling the computation of PGS for external genomes and exomes. The pipeline, accessible on GitHub, supports parallel tasks on various computing platforms and contributes to the standardization of PGS comparisons globally. Lastly, a user-friendly web interface facilitates the exploration of PGS reference distributions, featuring a detailed table, distribution plots, and filtering options. This interface enhances accessibility for researchers and clinicians, fostering informed decision-making based on population-specific PGS distributions. The PGS reference distributions can be explored at the SpPGS Atlas repository through the web interface: https://csvs.clinbioinfosspa.es/?tab=pgs . Sun, 01 Feb 2026 00:00:00 GMT https://sms.carm.es/ricsmur/handle/123456789/25826 2026-02-01T00:00:00Z https://sms.carm.es/ricsmur/handle/123456789/25823 Irregular antibodies in pregnancy during the universal anti-RHD prophylaxis era: a survey of Spanish Hospitals Rodríguez-Aliberas, Marta; Romón-Alonso, Íñigo; García-Rey, Enric; Viejo-Llorente, Aurora; Funes-Vera, Consuelo; Mingot-Castellano, María-Eva; Solves-Alcaina, Pilar; García-Gala, José María; Polo-Escriche, Ana; Bueno-Cabrera, José-Luis; Pons-Escoll, Verónica; Céspedes-López, roberto; Falcón-Rodríguez, María; Gómez-Calafat, Montse; Rodríguez-Whilhemi, Pablo; Palafox-Camps, Cristian; Domínguez-Acosta, Lourdes; Álvarez, Miguel Ángel; Fornells-Albanell, Jordi; Moreno-Risco, María-Belén; Moreno-Jiménez, Gemma; Galende Del Canto, Josefina; Ramiro-Infante, Laia; Hernández-García, María del Carmen; Pinacho-Oyarzabal, Asunción; Fernández-Galán, María-Ángeles; Delgado-Casado, Elena; Callao-Molina, Virginia; Muñiz-Diaz, Eduardo BACKGROUND: Although great advances have been made in the prevention of hemolytic disease of the fetus and newborn, especially for anti-D, irregular antibodies still appear. In order to ascertain the situation in Spain, we conducted a survey among hospitals treating pregnant women. MATERIALS AND METHODS: We sent a survey to Spanish public hospitals comprising demographical data (ethnicity, number of pregnancies, type of fertilization), characteristics of antibodies (specificity, number, antigenic compatibility), cause of alloimmunization and the clinical consequences (fetal death, icterus, anemia) between 2016 and 2021. We characterized the risk posed by antibodies and their clinical impact according to previously described criteria. RESULTS: During the study period, 574,140 children were born in the responding hospitals. Antibodies were detected in 1,055 women with 1,112 pregnancies, resulting in a 0.19% alloimmunization prevalence. The most common antibodies were anti-D (No.=393, 28.7%), anti-c (No.=204, 14.9%), anti-E (No.=199, 14.6%), anti-M (No.=129, 9.4%), and anti-Kell (No.=114, 8.3%). Incorrect prophylaxis administration in the current or past pregnancy accounted for 88.6% of anti-D, and 12 (6.5%) arose from an RhD-positive transfusion. When analyzing incompatible pregnancies (No.=424; 38%), 103 (24.3%) presented severe or very severe hemolytic disease, most of which (No.=92, 89%) were produced by high-risk antibodies, while only 11 cases were caused by medium-risk antibodies. DISCUSSION: The prevalence of irregular antibodies during pregnancy in Spain is lower than previously described for other Western countries. The most important antibodies are anti-D, anti-c and anti-K. More efforts to characterize antibodies should be made in order to reduce their prevalence and clinical impact. Mon, 19 Jan 2026 00:00:00 GMT https://sms.carm.es/ricsmur/handle/123456789/25823 2026-01-19T00:00:00Z https://sms.carm.es/ricsmur/handle/123456789/25822 Correction: Early initiation of SGLT2 inhibitors within guideline-directed medical therapy and outcomes in newly diagnosed heart failure patients (BMC Cardiovascular Disorders, (2025), 25, 1, (879), 10.1186/s12872-025-05316-0) Esteban-Fernández, Alberto; López-Fernández, Silvia; Pastor-Pérez, Francisco-José; Pérez-Rivera, José Ángel; Bonilla-Palomas, Juan Luis; Cobo-Marcos, Marta; García-Pinilla, José Manuel; Almenar-Bonet, Luis; Fluviá-Brugués, Paula; Bermúdez-Jiménez, Francisco J; Goena-Vives, Cristina; López-López, Andrea; Gómez-Otero, Inés Thu, 05 Feb 2026 00:00:00 GMT https://sms.carm.es/ricsmur/handle/123456789/25822 2026-02-05T00:00:00Z https://sms.carm.es/ricsmur/handle/123456789/25821 Discordant Patch Test Reactions to 2-Bromo-2-Nitro-Propane-1,3-Diol (Bronopol): A Multicenter Study From REIDAC Sanz-Sánchez, Tatiana; Giménez-Arnau, Ana María; Zaragoza-Ninet, Violeta; Córdoba-Guijarro, Susana; Miquel-Miquel, Francisco Javier; Silvestre-Salvador, Juan-Francisco; González-Pérez, Ricardo; Ruiz-González, Inmaculada; Mercader-García, Pedro; Serra-Baldrich, Esther; Carrascosa-rrillo, José-Manuel; Tous-Romero, Fátima; Ortiz-de Frutos, Francisco-Javier; Rodríguez-Serna, Mercedes; Gatica-Ortega, María-Elena; Paredes-Suárez, Carmen; Navarro-Triviño, Francisco; Chicharro, Pablo; Pastor-Nieto, María-Antonia; Gómez de la Fuente, Enrique; Sánchez-Gilo, Araceli; Andreu-Barasoain, Marta; Pereyra Rodríguez, José Juan; Melé-i-Ninot, Gemma; Sánchez-Pedreño-Guillén, Paloma; Elosua-González, Marta; Grau-Pérez, Mercè; Descalzo, Miguel Ángel; Borrego, Leopoldo Wed, 01 Apr 2026 00:00:00 GMT https://sms.carm.es/ricsmur/handle/123456789/25821 2026-04-01T00:00:00Z