02.08.01. Investigación y comunicación científica

Risk factors for one-year mortality in 440 femoral peri-implant fractures: insights from the PIPPAS prospective, multicentre, observational study

2026-04-13T15:41:41Z

Risk factors for one-year mortality in 440 femoral peri-implant fractures: insights from the PIPPAS prospective, multicentre, observational study Aguado, Héctor-J; Castillón-Bernal, Pablo; Teixidor-Serra, Jordi; García-Sánchez, Yaiza; Muñoz-Vives, Josep-M; Camacho-Carrasco, Pilar; Jornet-Gibert, Montsant; Ojeda-Thies, Cristina; García-Portabella, Pablo; Pereda-Manso, Adela; Mateos-Álvarez, Elvira; García-Virto, Virginia; Noriega-González, David; Álvarez-Ramos, Begoña-A; Muñoz-Moreno, Mª-F; Arroyo-Hernantes, Irene; Martínez-Sellés, Carmen; Marín-Jiménez, Sergio; Acha, Adriana; Tomás-Hernández, Jordi; Selga-Marsà, Jordi; Andrés-Peiró, José-V; Piedra-Calle, Carlos; Blasco-Casado, Ferrán; Guerra-Farfán, Ernesto; Querolt-Coll, Jordi; de-Santamaría, Guillermo-T; Gil-Aliberas, Carles; Campuzano-Bitterling, Borja; Ajuria-Fernández, Eliam; Díaz-Suárez, Rebeca; Fernández-Manzano, Eugenia; De-Cortázar, Unai-G; Arrieta, Mirentxu; Escobar, Daniel; Castrillo, Estíbaliz; Balvis, Patricia; Denisiuk, Maciej; Moreta, Jesús; Uriarte, Xabier; Vea, Andrea; Jiménez-Tellería, Patricia; Olías-López, Beatriz; Amaya-Espinosa, Patricia; Boluda-Mengod, Juan; Borrás-Cebrián, Juan-C; Martínez-Pérez, Carles; Freile-Pazmiño, Patricio-A; Calavia-Calé, Pablo; Suárez-Suárez, Miguel-Á; García-Arias, Antonio; Valle-Cruz, José; García-Coiradas, Javier; Cano-Leira, María-Á; Bonome-Roel, César; Benjumea-Carrasco, Antonio; Chico-García, Marcos; Sánchez-Pérez, Coral; Priego-Sánchez, Rodrigo-J; Pariza, Ana-L; Fernández-Juan, Alexis; Saura-Sánchez, Eladio; Giménez-Ibáñez, Sandra; Sánchez-Gómez, Plácido; Ricón-Recarey, F-J; Jiménez-Olivares, Jesús; Correoso-Castellanos, Silvia; García, Elena-M; Medrano-Morte, Isabel; Cuadrado-Abajo, Francisco; Laguna-Bercero, María-E; Pozo-Manrique, Pedro-D; Navas-García, Francisco-M-G; García-Paredero, Ester; Robles, Teresa-B; Navas-Pernía, Inés; Gálvez-Márquez, Gonzalo; Villasante-Jirón, Ignasi-D; Vilanova-Laguna, Joan; Videla-Ces, Miquel; Serra-Porta, Teresa; González-Ojeda, Gloria; Becerra, Carmen-C; Pena-Paz, Silvia; Fernández-Dorado, Fátima; Martínez-Menduiña, Amaia; Vaquerizo-García, Víctor; Murcia-Asensio, Antonio; Galián-Muñoz, Elena; Marín-Martínez, Carmelo; Muñoz-Vicente, Adrián; Plaza-Salazar, Nuria; Gámez-Asunción, Carla; Benito-Santamaría, Jennifer; González, Ana-V; Viana, Laura-A; Mingo-Robinet, Juan; Barbería-Biurrun, Amaya; Escudero-Martínez, Emma; Chouza-Montero, Laura; Naharro-Tobío, María; Gasset-Teixidor, Alfons; Domínguez-Ibarrola, Andrea; Peñalver, J-M; Serrano-Sanz, Jorge; Roche-Albero, Adrián; Martín-Hernández, Carlos; Macho-Mier, María; Segura-Nuez, Julián-C; Saló-Cuenca, José-C; Roselló, Jordi-E; Criado-Albillos, Guillermo; Cabello-Benavides, Hugo-G; Nestar, David-A; Martínez-Íñiguez-Blasco, Jorge; Bogallo-Dorado, José-M; Cano-Porras, Juan-R; Marqués-López, Fernando; Martínez-Díaz, Santos; Carabelli, Guido-S; Slullitel, Pablo-I; Astore, Ignacio; Hernández-Pascual, Carlos; Marín-Sánchez, Javier; Dot-Pascuet, Iván; Piñeiro-Borrero, Ana; Pérez-Sánchez, José-M; Mandía-Martínez, Alfonso; Caso-Rodríguez, Julio-D; Martín-Marcuello, Jordi; Benito-Mateo, Miguel; Jaúregui-Garasa, Ainhoa; Gabarain-Morcillo, Imanol; González-Panisello, María-R; Miñana-Barrios, Marta; Iglesias-Fernández, Susana; García-Albea, Raquel; González-López, María-C AIMS: The Peri-Implant and PeriProsthetic Survival AnalysiS (PIPPAS) study aimed to investigate the risk factors for one-year mortality of femoral peri-implant fractures (FPIFs). METHODS: This prospective, multicentre, observational study involved 440 FPIF patients with a minimum one-year follow-up. Data on demographics, clinical features, fracture characteristics, management, and mortality rates were collected and analyzed using both univariate and multivariate analyses. FPIF patients were elderly (median age 87 years (IQR 81 to 92)), mostly female (82.5%, n = 363), and frail: median clinical frailty scale 6 (IQR 4 to 7), median Pfeiffer 4 (1 to 7), median age-adjusted Charlson Comorbidity Index (CCI) 6 (IQR 5 to 7), and 58.9% (n = 250) were American Society of Anesthesiologists grade III. RESULTS: Overall, 90.5% (n = 398) of the patients were treated surgically, 57.0% (n = 227) retained the implant, and 88.7% (n = 353) managed with fixation. Mortality rates were 8.2% (n = 3.6) in-hospital, 11.4% (n = 50) at 30 days, 21.1% (n = 93) at six months, and 21.6% (n = 95) at 12 months. Medical complications, mainly delirium, were common in the acute setting (52.7%, n = 215). The nonunion rate was 4.1% (n = 18). Mortality risk factors in the univariate analysis were age, living at a nursing home, no walking outdoors, frailty variables, fractures in the distal epiphysis, fractures around a proximal nail, discharge to a healthcare facility, and no osteoporotic treatment at discharge. Protective factors against mortality in the univariate analysis were surgical treatment by an experienced surgeon, management without an arthroplasty, allowing full weightbearing, mobilization in the first 48 hours postoperatively, and geriatric involvement. Risk factors for mortality in the multivariate analysis were cognitive impairment (Pfeiffer's questionnaire) (hazard ratio (HR) 1.14 (95% CI 1.05 to 1.23), p = 0.002), age-adjusted CCI (HR 1.18 (95% CI 1.07 to 1.30), p = 0.001), and antiaggregant or anticoagulant medication at admission (HR 2.00 (95% CI 1.19 to 3.38), p = 0.009). Haemoglobin level at admission was protective against mortality (HR 0.85 (95% CI 0.74 to 0.97), p = 0.018). CONCLUSION: Mortality in FPIFs occurs mainly within the first six months of follow-up. Early co-management and clinical optimization, particularly targeting frail older patients, is crucial in reducing mortality following these fractures.

The metabolic score for insulin resistance predicts the risk of cardiovascular disease in patients with psoriatic arthritis: results from the 10-year prospective CARMA cohort

2026-03-17T12:50:18Z

The metabolic score for insulin resistance predicts the risk of cardiovascular disease in patients with psoriatic arthritis: results from the 10-year prospective CARMA cohort Gonzalez-Gay, Miguel-A; Ferraz-Amaro, Ivan; Castañeda, Santos; Pinto-Tasende, José-A; Uriarte-Ecenarro, Miren; Plaza, Zulema; Sánchez-Alonso, Fernando; García-Gómez, Carmen; González-Juanatey, Carlos; Llorca, Javier; Fernández-Sueiro, José-L; Pinto-Tasende, José-A; González-de-Rábago, Eugenia; González-Fernández, María-J; Huguet-Codina, Ramón; Yoldi, Beatriz; Ramentol, Mercedes; Marsal, Sara; Ávila, Gabriela; Alegre, Cayetano; Steiner, Martina; Cobo, Tatiana; Muñoz, Santiago; Gamero, Fernando; Torón, José-García; Moreno-Gil, María-P; Mas, Antonio-J; Espiño, Pilar; Ros, Inmaculada; Ibáñez, Mónica; Tornero, Jesús; Piqueras, José-A; Sanmartí, Raimon; Berman, Horacio; Patón, Oscar-Fontseré; Fernáncez-Gutiérrez, Benjamín; Abasolo, Lydia; Pina-Salvador, José-M; Fábregas, María-D; Romera, Montserrat; Nolla, Joan-M; Uriarte-Ecenarro, Miren; García-Vadillo, Jesús-A; García-de-Vicuña, Rosario; Chamizo-Carmona, Eugenio; Fernández-Nebro, Antonio; Ureña, Inmaculada; Belmonte, María-A; Irigoyen, María-V; Martínez-González, Olga; Belmonte-Gómez, Rebeca; Granados-Bautista, Pastora; Hernández-Sanz, Azucena; Rey, José-Santos; Sánchez-González, Carmen-O; Bachiller, Javier; Zea, Antonio; Manero, Francisco-J; Beltrán-Audera, Chesús; Medrano, Marta; Pecondón, Ángela; Erausquin, Celia; Ojeda, Soledad; Rodríguez-Lozano, Carlos; Babío-Herráez, Jesús; López-Longo, Francisco-J; Monteagudo, Indalecio; del-Pino, Javie; López-González, Ruth; González-Gay, Miguel-A; Corrales, Alfonso; Peiró, María-Enriqueta; Senabre, José-M; Rosas, José-C; Rotés, Isabel; Moreno, Estefanía; Erra, Alba; Calvo, Javier; Rueda, Amalia; Möller, Ingrid; Rodríguez, Isabel; Barbadillo, Carmen; Raya, Enrique; Morales, Pilar; Nieto, Ana; Ruibal-Escribano, Ana; García-Gómez, Carmen; Ros-Expósito, Sergio; Sánchez-Nievas, Ginés; Júdez-Navarro, Enrique; Sianes-Fernández, Manuela; Pardo, Silvia-Martínez; Pujol, Manel; González-Álvarez, Beatriz; Cantabrana, Alberto; Bustabad, Sagrario; Delgado, Esmeralda; Muñoz, Alejandro; Rodríguez-Montero, Sergio; Rivera-Redondo, Javier; González-Hernández, Teresa; González-Polo, Francisco-J; Menor-Almagro, Raúl; Moreno, José-M; Serret, Emilio-Giner; Cebrián-Méndez, Laura; Navío, María-Teresa; Pedraz-Penalva, Teresa; Fernández-Carballido, Cristina; Pagán, Encarnación; Mesa-del-Castillo, Pablo; Naredo, Esperanza; Cruz, Ana; Turrión, Ana; Pérez-Gómez, Ana; Sánchez, Julio; Galindo, María; Collantes, Eduardo; Ruíz, Desireé; Font, Pilar; Bonilla, Gema; López-Meseguer, Antonio; Moreno, Manuel-J; Linares-Ferrando, Luis-Francisco; Morcillo, Mercedes; González-Gómez, María-L; Aramburu, José-M; Rivera, Natalia-A; Fernández-Berrizbeitia, Olaia; Park, Hye-Sang; Riera, Manel; León, Yolanda-María; Pérez-García, Carolina; Maymó, Joan; Amirall, Miriam; Fiter, Jordi; Fernández-Melón, Julia; Espadaler, Luis; Belzunegui, Joaquín; Bañegil, Inmaculada; Díaz, César; Valls, Ramón; Castellví, Iván; Bonet, María; Calvo-Alén, Jaime; Sandoval, Trinidad-Pérez; Revuelta-Evrard, Eva; Godo, Javier-R; González-Fernández, José-Antonio; Miranda-Filloy, José-A OBJECTIVE: To evaluate the predictive value of the metabolic score for insulin resistance (METS-IR) in identifying patients with psoriatic arthritis (PsA) at high risk of cardiovascular (CV) events. METHODS: Assessment of patients with PsA enrolled in the Spanish prospective CARdiovascular in ReuMAtology (CARMA) project. Baseline data from 500 PsA patients without a history of CV events, chronic kidney disease, diabetes mellitus or statin use at the baseline visit were analysed. Patients were prospectively followed for 10 years in rheumatology outpatient clinics at tertiary centres. The performance of the METS-IR in predicting CV events was evaluated. METS-IR was categorised into three groups: <2.25, 2.25-2.48 and >2.48. RESULTS: Over 4788 patient-years of follow-up, 27 individuals experienced at least one CV event. The annualised incidence rate was 5.6 events per 1000 patient-years (95% CI: 3.7 to 8.2). PsA patients with CV events had significantly higher METS-IR scores than those without CV events (2.37±0.24 vs 2.26±0.19; p=0.01). In this regard, patients who had CV events were more commonly included in the METS-IR 2.25-2.48 and >2.48 categories than those without CV events (p=0.008). Adjusted regression models indicated that PsA patients with a METS-IR >2.48 at baseline had an increased risk of experiencing a CV event during the follow-up period. CONCLUSIONS: In PsA patients under close observation in rheumatology units included in the prospective CARMA project, METS-IR serves as a reliable prognostic predictor of CV.

Relapsing laryngeal granuloma resolved after excluding cola drinks from diet: Case report

2026-03-10T12:10:29Z

Relapsing laryngeal granuloma resolved after excluding cola drinks from diet: Case report Raposo-Jiménez, Alberto; Lajara, Jeronimo; García-Purrinos, Francisco-José

Predicting Hospitalisation In Older Patients Attended In The Emergency Department Using Classical And Aritficaiil Intelligence Mathematical Strategies

2026-03-10T12:10:29Z

Predicting Hospitalisation In Older Patients Attended In The Emergency Department Using Classical And Aritficaiil Intelligence Mathematical Strategies Aguirre, Nere-L; Gutiérrez, Susana-G; Miró, Oscar; Jacob, Javier; Llorens, Pere; Burillo-Putze, Guillermo; Fernández, Cesareo; Alquezar-Arbe, Aitor; Aguilo, Sira; Montero-Pérez, Francisco-J; Bermejo, José-J-N; Vera, María-T-Maza; García-García, Ángel; Ezponda, Patxi; Lorenzo, Andrea-M; Fernández-Simón-Almela, Amparo; Santos-Martín, José-M; Ramon, Susana-S; Liarte, Juan-V-O; Berenguer-Díez, María-A; Puente, Pablo-H; Olaguenaga, Ana-M; Fernández, Elena-C; Molina, Laura; Juan, María-M; Rodríguez, Eva-de-las-Nieves; González-del-Castillo, Juan