Impact of Prior Biologic Mechanism of Action on Anti-TNF Effectiveness in Inflammatory Bowel Disease: An ENEIDA Registry Study

2026-10-28T08:26:25Z

Impact of Prior Biologic Mechanism of Action on Anti-TNF Effectiveness in Inflammatory Bowel Disease: An ENEIDA Registry Study Yague-Caballero, Carmen; García-López, Santiago; Royo-Esteban, Ana; Figueras-Panillo, Laura; Nos, Pilar; de-Castro, Luisa; Martin-Arranz, M-Dolores; Barreiro-de-Acosta, Manuel; Ricart, Elena; de-Francisco, Ruth; Iglesias, Eva; Giordano, Antonio; Varela, Pilar; Rodríguez-Lago, Iago; Rivero, Montserrat; Sicilia, Beatriz; Navarro-Llavat, Merce; Vera, Isabel; Suria, Carles; Guardiola, Jordi; Barrio, Jesus; Calafat, Margalida; Gutiérrez, Ana; Calvet, Xavier; de-la-Cruz, David-Rafael; Mesonero, Francisco; Martínez-Pascual, Cristina; Gisbert, Javier-P; Gargallo-Puyuelo, Carla-J; Monfort-I-Miquel, David; Sierra, Monica; Arranz, Laura; Rodríguez-Gutiérrez, Cristina; Lorente, Rufo; Bermejo, Fernando; Marquez-Mosquera, Lucía; Torres-Vicente, Gisela; Pérez-Calle, José-Lazaro; Huguet, José-M; Ramos, Laura; Ponferrada-Diaz, Angel; Ceballos, Daniel; Diz-Lois-Palomares, Ma-Teresa; Sese-Abizanda, Eva; Vega, Pablo; Pajares, Ramon; Santos-Fernández, Javier; Betore, Elena; Busquets, David; Merino, Olga; Martínez-Flores, Carlos; Zabana, Yamile; Sampedro-González, Manuela-Josefa; Ortiz-de-Zarate, Jone; Fuentes-Coronel, Ana; Sainz-Arnau, Empar; Carpio, Daniel; Jimenez, Nuria; Marin-Jimenez, Ignacio; Bujanda, Luis; Camargo-Camero, Raquel; Irabien, Martin; Abanades-Tercero, María; Velayos-Jimenez, Benito; Robledo-Andres, Pilar; Trapero, Ana-María; Delgado-Guillena, Pedro-G; Hernández-Villalba, Luis; Menacho, Margarita; Rull-Murillo, Nuria; Leal, Carles; Alba, Cristina; Gómez-Espín, Rosa; Lucendo, Alfredo-J; Van-Domselaar, Manuel; García-Alles, Laura; Iyo-Miyashiro, Eduardo; Crespo-Catala, Ana; Gilabert, Pau; Martin-Rodríguez, Daniel; Navas-López, Victor-Manuel; Calvo-Iniguez, María; Ginard, Daniel; Martínez-Pérez, Teresa; Domenech, Eugeni; Casas-Deza, Diego BACKGROUND: The expanding use of targeted therapies in inflammatory bowel disease has made treatment sequencing increasingly relevant, yet evidence on anti-TNF effectiveness after prior biologics with different mechanisms of action (MOA) remains limited. Our objective is to evaluate the durability of anti-TNF treatment in this scenario. METHODS: Multicentre study based on data from the ENEIDA registry. Patients who received second-line anti-TNF therapy after a first biologic with a different MOA for active luminal disease were identified. Using propensity score matching, each case was matched with three controls from two cohorts: patients treated with second-line anti-TNF after another anti-TNF and patients receiving first-line anti-TNF therapy. Treatment durability and short- and long-term clinical effectiveness were assessed. RESULTS: Sixty-six Crohn's disease patients and 117 UC patients receiving anti-TNF after other MOA were included. In CD, second-line anti-TNF therapy after a different MOA (62% ustekinumab) was associated with a higher risk of treatment discontinuation compared with first-line anti-TNF therapy (HR 1.55; 95% CI, 1.05-2.30), without significant differences in short- or long-term clinical effectiveness. In UC, anti-TNF therapy after a different MOA (90% vedolizumab) was associated with lower treatment durability compared with first-line anti-TNF therapy (HR 1.69; 95% CI, 1.31-2.19) and with anti-TNF after another anti-TNF agent (HR 1.91; 95% CI, 1.48-2.48), its remission rates significantly lower at both short- and long-term follow-up (p < 0.001). CONCLUSIONS: Anti-TNF therapy used after a different MOA is associated with reduced effectiveness and durability compared with its use as first-line therapy or after another anti-TNF agent, especially in UC.

Post-Acute Nasal Expression of ACE2, TMPRSS2, FURIN, and NRP1 in Relation to COVID-19 Severity: A Multicenter Cross-Sectional Study

2026-10-28T08:27:56Z

Post-Acute Nasal Expression of ACE2, TMPRSS2, FURIN, and NRP1 in Relation to COVID-19 Severity: A Multicenter Cross-Sectional Study Piqueras-Sánchez, Ana-María; López-Gil, José-Francisco; Hellín-Meseguer, Diego; Cabezas-Herrera, Juan; Blesa-Llaona, Ginés-Francisco; Meseguer-Cabezas, José; Bernal-Morell, Enrique; Minguela-Puras, Alfredo; Piqueras-Pérez, Francisco; Díaz-Manzano, José-Antonio

Risk Factors for Postoperative Complications in Hallux Valgus Surgery: A Retrospective Cohort Study

2026-10-28T08:27:56Z

Risk Factors for Postoperative Complications in Hallux Valgus Surgery: A Retrospective Cohort Study Buendía-Ayala, Isabel; Buendia-Ayala, Josefa; Ridgell, Lucille; Mino, Camila; López-Gil, José-Francisco; Tarraga-López, Pedro-Juan; López-Cara, Mateo-Amando

A Simplified Model of the Knee for Coronal Plane Alignment of the Knee Simulation

2026-10-28T08:27:56Z

A Simplified Model of the Knee for Coronal Plane Alignment of the Knee Simulation Rodríguez-Pereira, Cesar; Gracia-Rodríguez, Javier; Sánchez-Lasheras, Fernando; Iglesias-Rodríguez, Francisco-Javier; Murcia-Asensio, Antonio

02.07. Área de Salud VII Murcia Este

Impact of Prior Biologic Mechanism of Action on Anti-TNF Effectiveness in Inflammatory Bowel Disease: An ENEIDA Registry Study

Post-Acute Nasal Expression of ACE2, TMPRSS2, FURIN, and NRP1 in Relation to COVID-19 Severity: A Multicenter Cross-Sectional Study

Risk Factors for Postoperative Complications in Hallux Valgus Surgery: A Retrospective Cohort Study

A Simplified Model of the Knee for Coronal Plane Alignment of the Knee Simulation