02.03. Área de Salud III Lorcahttps://sms.carm.es/ricsmur/handle/123456789/171642026-10-04T12:17:02Z2026-10-04T12:17:02ZErgonomic Risk in Total Hip Arthroplasty: Approach-Specific Postural Loads and Position-Swap Effects During Cup PreparationMarín-Martínez, CarmeloMantilla-de-los-Ríos-García, José-EmilioGalián-Muñoz, ElenaSánchez-Robles, MarinaLeón-Muñoz, Vicente-JesúsMurcia-Asensio, AntonioMoreno-Cascales, MatildeLajara-Marco, Franciscohttps://sms.carm.es/ricsmur/handle/123456789/281862026-09-18T05:52:30Z2026-04-01T00:00:00ZErgonomic Risk in Total Hip Arthroplasty: Approach-Specific Postural Loads and Position-Swap Effects During Cup Preparation
Marín-Martínez, Carmelo; Mantilla-de-los-Ríos-García, José-Emilio; Galián-Muñoz, Elena; Sánchez-Robles, Marina; León-Muñoz, Vicente-Jesús; Murcia-Asensio, Antonio; Moreno-Cascales, Matilde; Lajara-Marco, Francisco
2026-04-01T00:00:00ZImplementation of quantitative HBsAg testing in clinical microbiology laboratories in Spain: Results from a national GEHEP-SEIMC surveyChaves-Blanco, LucíaIllescas-López, MartaFuentes, AnaCarracedo, RaquelDelgado-Iribarren, AlbertoVázquez-Blanquino, AlbertoBlázquez, Ana-MaríaSaez, RuthMiqueleiz, Anade-los-Reyes-Vidal, MaríaTosco, TomasGómez, CésarMoldes, LuzCalvo, NoeliaPérez-Rodríguez, LucíaTrigo, MatildeDolores-Ocete, MaríaAlcaraz, María-JesúsAsuncion-Iborra, MaríaGarcía, JulioJoaquin-Blas, JoséMaría-Vallejo, AldaraAlberola-Romano, AnaIllescas, SoledadRodríguez, Juan-CarlosAlonso, RobertoCámara, MargaritaDolores-Navarro, MaríaLuisa-Núñez, Maríadel-Amor-Espín, María-JesúsBeteta, AliciaCascales-Alcolea, EvaMiguel-Soria, LuisGacinuno, SonsolesSandoval, MartaCortizo, SandraOrdóñez, PatriciaLiendo, PalomaPérez, MercedesÁlvarez-Arguelles, MartaGarcía, FernandoRodríguez, InmaculadaGómez, CarmenElorduy, LuisHernández-Febles, MelisaGonzález-Praetorius, AlejandroLiebana, CarmenLourdes-Molina, MaríaSalicio, YolandaMacho, MikeleBecerril, BertaFranco-Álvarez, FranciscoFalcés-Romero, IkerAlgarete, SoniaJose-Gude, MaríaPablo, DanielMagdalena-Lara, MaríaMontiel, NataliaFreyre, CarolinaGalán, Juan-CarlosPérez, Ana-BelénLorenzo, BelénFraile, PabloSánchez-Yebra, WaldoViciana, IsabelSampedro, Antoniodel-Carmen-Lozano, MaríaDomínguez-Castano, AnaRamírez, EncarnaciónBeltran, InocencioMartin, TeresaPuerta, AntonioTajada, PilarPanes, PaulaMartín, AdriánHurtado, Juan-CarlosLópez-Braos, JavierArjona, FranciscoMiro, ElisendaRuiz, MontserratRamírez, MercedesGil-Fortuno, MaríaGonzález-Pellicer, RosaAcedo, Juan-ManuelAnel-Pedroche, JorgeInfante-Urrios, AnaDomínguez, VictoriaAran-Toha, GuillermoMrtinez-Macias, OlallaOrta-Mira, NievesTorres-Sopena, LuisCantudo, PurificaciónAraceli-Hernández, MaríaArroyo-Serrano, TeresaRando, AriadnaGarrido, MartaFernández, Gemade-Salazar, AdolfoAguilera, AntonioGarcía, Federicohttps://sms.carm.es/ricsmur/handle/123456789/281772026-09-18T05:51:00Z2026-08-01T00:00:00ZImplementation of quantitative HBsAg testing in clinical microbiology laboratories in Spain: Results from a national GEHEP-SEIMC survey
Chaves-Blanco, Lucía; Illescas-López, Marta; Fuentes, Ana; Carracedo, Raquel; Delgado-Iribarren, Alberto; Vázquez-Blanquino, Alberto; Blázquez, Ana-María; Saez, Ruth; Miqueleiz, Ana; de-los-Reyes-Vidal, María; Tosco, Tomas; Gómez, César; Moldes, Luz; Calvo, Noelia; Pérez-Rodríguez, Lucía; Trigo, Matilde; Dolores-Ocete, María; Alcaraz, María-Jesús; Asuncion-Iborra, María; García, Julio; Joaquin-Blas, José; María-Vallejo, Aldara; Alberola-Romano, Ana; Illescas, Soledad; Rodríguez, Juan-Carlos; Alonso, Roberto; Cámara, Margarita; Dolores-Navarro, María; Luisa-Núñez, María; del-Amor-Espín, María-Jesús; Beteta, Alicia; Cascales-Alcolea, Eva; Miguel-Soria, Luis; Gacinuno, Sonsoles; Sandoval, Marta; Cortizo, Sandra; Ordóñez, Patricia; Liendo, Paloma; Pérez, Mercedes; Álvarez-Arguelles, Marta; García, Fernando; Rodríguez, Inmaculada; Gómez, Carmen; Elorduy, Luis; Hernández-Febles, Melisa; González-Praetorius, Alejandro; Liebana, Carmen; Lourdes-Molina, María; Salicio, Yolanda; Macho, Mikele; Becerril, Berta; Franco-Álvarez, Francisco; Falcés-Romero, Iker; Algarete, Sonia; Jose-Gude, María; Pablo, Daniel; Magdalena-Lara, María; Montiel, Natalia; Freyre, Carolina; Galán, Juan-Carlos; Pérez, Ana-Belén; Lorenzo, Belén; Fraile, Pablo; Sánchez-Yebra, Waldo; Viciana, Isabel; Sampedro, Antonio; del-Carmen-Lozano, María; Domínguez-Castano, Ana; Ramírez, Encarnación; Beltran, Inocencio; Martin, Teresa; Puerta, Antonio; Tajada, Pilar; Panes, Paula; Martín, Adrián; Hurtado, Juan-Carlos; López-Braos, Javier; Arjona, Francisco; Miro, Elisenda; Ruiz, Montserrat; Ramírez, Mercedes; Gil-Fortuno, María; González-Pellicer, Rosa; Acedo, Juan-Manuel; Anel-Pedroche, Jorge; Infante-Urrios, Ana; Domínguez, Victoria; Aran-Toha, Guillermo; Mrtinez-Macias, Olalla; Orta-Mira, Nieves; Torres-Sopena, Luis; Cantudo, Purificación; Araceli-Hernández, María; Arroyo-Serrano, Teresa; Rando, Ariadna; Garrido, Marta; Fernández, Gema; de-Salazar, Adolfo; Aguilera, Antonio; García, Federico
2026-08-01T00:00:00ZWork-Related Musculoskeletal Symptoms in Surgeons Performing Total Knee Arthroplasty: An Exploratory Cross-Sectional SurveySánchez-Robles, MarinaMarín-Martínez, CarmeloMoya-Angeler, JoaquínLeón-Muñoz, Vicente-JesúsLajara-Marco, Franciscohttps://sms.carm.es/ricsmur/handle/123456789/281632026-09-18T05:52:35Z2026-06-28T00:00:00ZWork-Related Musculoskeletal Symptoms in Surgeons Performing Total Knee Arthroplasty: An Exploratory Cross-Sectional Survey
Sánchez-Robles, Marina; Marín-Martínez, Carmelo; Moya-Angeler, Joaquín; León-Muñoz, Vicente-Jesús; Lajara-Marco, Francisco
Background: Work-related musculoskeletal disorders (WRMSDs) are highly prevalent among orthopaedic surgeons, but procedure-related symptom patterns, symptom intensity, and perceived interference remain incompletely characterised. This exploratory cross-sectional study evaluated the prevalence, anatomical distribution, and occupational consequences of musculoskeletal symptoms among surgeons performing total knee arthroplasty (TKA) and explored a non-validated descriptive discomfort-interference composite score. Methods: A cross-sectional survey was administered to a diverse group of 72 orthopaedic surgeons in Spain who performed TKA as part of their broader orthopaedic practice. Data on demographics, anatomical discomfort, global discomfort intensity, and functional interference were collected. A raw discomfort-interference score (DIIraw, 0-600) and a normalised score (DII100, 0-100) were calculated strictly as exploratory descriptors. Subgroup comparisons were performed according to the surgical position adopted during TKA. Results: The prevalence of musculoskeletal symptoms was 81.9%, with the lumbar spine (47.2%) and neck (38.9%) being the most affected regions. Mean global VAS discomfort was low (1.94 ± 2.08; median 1.0 [0.0-3.0]), although 15.3% of participants reported VAS ? 5. Self-reported physician-diagnosed work-related musculoskeletal conditions were reported by 51.4%, with 5.6% reporting sick leave and 6.9% reporting surgical intervention. DII100 values were low and skewed (mean 1.41 ± 2.31; median 0.25 [0.0-1.75]). No statistically significant differences were observed across surgical positions. Conclusions: Musculoskeletal symptoms were common among surgeons performing TKA, mainly affecting the lumbar and cervical regions, but average symptom intensity was low. A smaller subset reported clinically relevant discomfort and occupational consequences. The discomfort-interference composite score and any distribution-based values should be interpreted only as exploratory descriptors and require external validation. This study found no evidence of differences in musculoskeletal burden between surgical positions.
2026-06-28T00:00:00ZOzanimod Reduces Serum Neurofilament Light Chain (NfL) and Glial Fibrillary Acidic Protein (GFAP) and Modulates Innate and Adaptive Immunity in Patients with Low-to-Moderate Activity Relapsing-Remitting Multiple SclerosisCosta-Frossard, LucienneBrieva, LuisGarcía-Estévez, Daniel-ApolinarMartin-Martínez, Jesus-ManuelÁlvarez-Bravo, GaryBlasco-Quilez, María-RosarioMeca-Lallana, José-EustasioCalles-Hernández, María-CarmenRamo-Tello, CristinaMuñoz-Fernández, CarmenBarbero, David-EnriqueLópez-Muñoz, PabloPrieto-González, José-MaríaCandeliere-Merlicco, AntonioCarmona, OlgaRiancho, JavierSola-Valls, NuriaCarcelen-Gadea, MaríaBorrega, LauraGascon-Giménez, FranciscoVilanova, DavidPérez, XavierVillar, Luisa-Maríahttps://sms.carm.es/ricsmur/handle/123456789/281522026-09-18T05:52:33Z2026-05-29T00:00:00ZOzanimod Reduces Serum Neurofilament Light Chain (NfL) and Glial Fibrillary Acidic Protein (GFAP) and Modulates Innate and Adaptive Immunity in Patients with Low-to-Moderate Activity Relapsing-Remitting Multiple Sclerosis
Costa-Frossard, Lucienne; Brieva, Luis; García-Estévez, Daniel-Apolinar; Martin-Martínez, Jesus-Manuel; Álvarez-Bravo, Gary; Blasco-Quilez, María-Rosario; Meca-Lallana, José-Eustasio; Calles-Hernández, María-Carmen; Ramo-Tello, Cristina; Muñoz-Fernández, Carmen; Barbero, David-Enrique; López-Muñoz, Pablo; Prieto-González, José-María; Candeliere-Merlicco, Antonio; Carmona, Olga; Riancho, Javier; Sola-Valls, Nuria; Carcelen-Gadea, María; Borrega, Laura; Gascon-Giménez, Francisco; Vilanova, David; Pérez, Xavier; Villar, Luisa-María
Relapsing-remitting multiple sclerosis (RRMS) is characterized by neuroaxonal damage, astrogliosis and inflammation. These mechanisms may already be active from early disease stages, underscoring the need for sensitive biomarkers capable of capturing treatment-related biological effects beyond conventional clinical measures. In this multicenter, ambispective, observational real-world study, the longitudinal effects of ozanimod on serum biomarkers were evaluated, during the first year of treatment in patients with low-to-moderate activity RRMS. Serum neurofilament light chain (sNfL), glial fibrillary acidic protein (sGFAP) and cytokines associated with immune activity (IFN-?, IL-17, IL-6, IL-10, and IL-1?) were quantified at baseline, 6 months, and 12 months using an ultrasensitive single-molecule array (SIMOA). Ozanimod was associated with significant reductions in sNfLs and sGFAP at 12 months. Concomitantly, significant decreases in IFN-? and IL-1? were observed. IL-17 levels remained unchanged in the overall cohort but decreased in patients with higher baseline IL-17 levels. These findings demonstrate coordinated modulation of biomarkers reflecting neuroaxonal damage, astroglial activation, and inflammatory activity under ozanimod treatment in early RRMS in real-world conditions. These results highlight the biological relevance of early intervention within a therapeutic window of opportunity and support the potential utility of serum biomarkers for monitoring biological treatment effects in clinical practice.
2026-05-29T00:00:00Z