02.02.01. Investigación y comunicación científica

A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia

2026-10-21T07:46:07Z

A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia Jiménez-Fonseca, Paula; Carmona-Bayonas, Alberto; Ayala-de-la-Peña, Francisco; Matos-García, Ignacio; Marcos, Rosana; Lozano, Rebeca; Jesus-Cruz, Juan; Castanon, Eduardo; Antonio, Maite; Font, Carme; Biosca, Merce; Blasco, Ana; García-Navalon, Francisco; Ramchandani, Avinash; Beato, Carmen; Martínez-de-Castro, Eva; Espinosa, Javier; Martínez-García, Jerónimo; Ghanem, Ismael; Hernando-Cubero, Jorge; Aragon-Manrique, Isabel; Sevillano, Elena; Manzano, Aranzazu; Virizuela, Juan; Garrido, Marcelo; Mondejar, Rebeca; Angeles-Arcusa, María; Bonilla-Pacheco, Yaiza; Perez, Quionia; Gallardo, Elena; del-Carmen-Soriano, María; Cardona, Merce; Sánchez-Lasheras, Fernando BACKGROUND: We sought to develop and externally validate a nomogram and web-based calculator to individually predict the development of serious complications in seemingly stable adult patients with solid tumours and episodes of febrile neutropenia (FN). PATIENTS AND METHODS: The data from the FINITE study (n=1133) and University of Salamanca Hospital (USH) FN registry (n=296) were used to develop and validate this tool. The main eligibility criterion was the presence of apparent clinical stability, defined as events without acute organ dysfunction, abnormal vital signs, or major infections. Discriminatory ability was measured as the concordance index and stratification into risk groups. RESULTS: The rate of infection-related complications in the FINITE and USH series was 13.4% and 18.6%, respectively. The nomogram used the following covariates: Eastern Cooperative Group (ECOG) Performance Status ?2, chronic obstructive pulmonary disease, chronic cardiovascular disease, mucositis of grade ?2 (National Cancer Institute Common Toxicity Criteria), monocytes <200/mm(3), and stress-induced hyperglycaemia. The nomogram predictions appeared to be well calibrated in both data sets (Hosmer-Lemeshow test, P>0.1). The concordance index was 0.855 and 0.831 in each series. Risk group stratification revealed a significant distinction in the proportion of complications. With a ?116-point cutoff, the nomogram yielded the following prognostic indices in the USH registry validation series: 66% sensitivity, 83% specificity, 3.88 positive likelihood ratio, 48% positive predictive value, and 91% negative predictive value. CONCLUSIONS: We have developed and externally validated a nomogram and web calculator to predict serious complications that can potentially impact decision-making in patients with seemingly stable FN.

Fetal MRI as Complementary Study of Congenital Cystic Adenomatoid Malformation During Pregnancy: A Single Case Report.

2026-10-21T07:52:46Z

Fetal MRI as Complementary Study of Congenital Cystic Adenomatoid Malformation During Pregnancy: A Single Case Report. Martínez-Mas, Jose; Miranda-Paanakker, Alberto; Gómez-Leal, Paloma; Navarro-Sánchez, Patricia; Bueno-Crespo, Andres; Martínez-Cendan, Juan-Pedro; Remezal-Solano, Manuel Fetal lung masses are rare findings in prenatal ultrasound scanning in general population, of which congenital cystic adenomatoid malformation is the most commonly diagnosed type. This paper reports a single case of congenital cystic adenomatoid malformation detected at our hospital and the subsequent clinical follow-up using ultrasound scanning and fetal magnetic resonance imaging.

Risk factors and therapeutic coverage at 6 years in patients with previous myocardial infarction: the CASTUO study.

2026-10-21T07:52:46Z

Risk factors and therapeutic coverage at 6 years in patients with previous myocardial infarction: the CASTUO study. Félix-Redondo, Francisco-Javier; Lozano-Mera, Luis; Consuegra-Sánchez, Luciano; Giménez-Saez, Fernando; Garciperez-de-Vargas, Francisco-Javier; Castellano-Vázquez, José-Maria; Fernández-Berges, Daniel OBJECTIVES: To determine the degree of risk factor control, the clinical symptoms and the therapeutic management of patients with a history of previous myocardial infarction. METHODS: Cross-sectional study at 6 years of a first episode of acute myocardial infarction between 2000 and 2009, admitted at a hospital in the region of Extremadura (Spain). Of 2177 patients with this diagnosis, 1365 remained alive and therefore were included in the study. RESULTS: We conducted a person-to-person survey in 666 (48.8%) individuals and telephone survey in 437 (31.9%) individuals. The former are analysed. 130 were female (19.5%). The mean age was 67.4 years and the median time since the event was 5.8 (IQR 3.6-8.2) years. Active smokers made up 13.8%, low-density lipoprotein (LDL) cholesterol was ?70 mg/dL: 82%, blood pressure ?140/90 mm Hg (?140/85 in diabetics): 49.8%, fasting glucose ?126 mg/dL: 26%, heart rate 50-59 bpm: 60.7%, and obesity: 45.9%. Patients reported presenting angina comprised 22.4% and those with dyspnoea, 29.3%. Drug coverage was: 88.0% antiplatelet drugs, 86.5% statins, 75.6% ?-blockers and 65.8% blockers of the renin-angiotensin system. Patients receiving all four types of drugs made up 41.9%, with only 3.0% having jointly controlled cholesterol, blood pressure, heart rate and glycaemia. CONCLUSIONS: LDL cholesterol, heart rate and blood pressure were risk factors with less control. More than 1/5 of patients had angina and more than 1/4, dyspnoea. Risk factor control and the clinical condition were far from optimal, as was drug coverage, although to a lesser degree.

Gastric varicella: two cases in cancer patients

2026-10-21T07:52:46Z

Gastric varicella: two cases in cancer patients Sastre-Lozano, Violeta-María; Martínez-García, Pilar; Torregrosa-Lloret, María; Sevilla-Cáceres, Laura; Romero-Cara, Patricia; Morán-Sánchez, Senador; Sánchez-Sánchez, Carlos Gastric involvement with the varicella-zoster virus is an uncommon clinical condition where early suspicion and diagnosis are important to prevent the consequences deriving from its high morbidity and mortality, which in immunocompromised patients oscillate between 9% and 41% according to the various series. Two cases of gastric involvement with the varicella-zoster virus (VZV) in two patients with blood cancer are reported below. Gastric lesions are usually preceded by typical papulovesicular skin lesions. When gastric involvement is the first symptom of the disease its diagnosis and management may be delayed, which may entail severe consequences for immunocompromised patients. It is therefore that we suggest its inclusion in the algorithm for immunocompromised patients with abdominal pain and ulcer-like endoscopic lesions.