https://sms.carm.es/ricsmur/handle/123456789/142 2026-04-16T21:27:47Z 2026-04-16T21:27:47Z Rizzolo-Brime, Lucía Lujan-Barroso, Leila Farran-Codina, Andreu Bou, Ricard Nicolas, Genevieve Huybrechts, Inge Lasheras, Cristina Molina-Montes, Esther Colorado-Yohar, Sandra Gasque, Alba Dahm, Christina C Bock, Niels Olsen, Anja Tjønneland, Anne Katzke, Verena le Cornet, Charlotte Schulze, Matthias B Saieva, Calogero Sieri, Sabina de Magistris, Maria Santucci Tumino, Rosario Macciotta, Alessandra Wareham, Nick Weiderpass, Elisabete Chatziioannou, Chrysovalantou Vineis, Paolo Jakszyn, Paula https://sms.carm.es/ricsmur/handle/123456789/25820 2026-04-13T13:39:26Z 2025-12-20T00:00:00Z

Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study Rizzolo-Brime, Lucía; Lujan-Barroso, Leila; Farran-Codina, Andreu; Bou, Ricard; Nicolas, Genevieve; Huybrechts, Inge; Lasheras, Cristina; Molina-Montes, Esther; Colorado-Yohar, Sandra; Gasque, Alba; Dahm, Christina C; Bock, Niels; Olsen, Anja; Tjønneland, Anne; Katzke, Verena; le Cornet, Charlotte; Schulze, Matthias B; Saieva, Calogero; Sieri, Sabina; de Magistris, Maria Santucci; Tumino, Rosario; Macciotta, Alessandra; Wareham, Nick; Weiderpass, Elisabete; Chatziioannou, Chrysovalantou; Vineis, Paolo; Jakszyn, Paula BACKGROUND: Processed meat (PM) consumption is an established risk factor for colorectal cancer (CRC). It has been hypothesized that nitrosyl-heme, formed by the addition of nitrites during meat processing, may enhance the carcinogenic effects of PMs. This study aims to investigate the association between nitrosyl-heme intake and CRC risk within the European Prospective Investigation into Cancer and Nutrition(EPIC) study. METHODS: This prospective study included 367,463 participants(70.3% women) from seven countries from the EPIC-study. Dietary data were collected via baseline questionnaires, and nitrosyl-heme exposure was estimated using biochemical data from 52 Spanish PMs, extrapolated to country-specific items. Sex-specific multivariable-adjusted hazard ratios(HRs) and 95% confidence intervals(CIs) were calculated using Cox proportional hazards models. RESULTS: Over a 15-year median follow-up, 5,115 incident CRC cases were identified. Comparing the highest vs. the lowest sex-specific tertile of nitrosyl-heme intake we found no significant association with CRC risk (HR(T3vsT1):1.01;95%CI:0.93-1.09). Subgroup analyses by tumor subtype and interactions with lifestyle factors also showed no associations. CONCLUSIONS: This study offers insights into nitrosyl-heme exposure in European populations but found no link to CRC risk. Further research is needed to understand nitrosyl-heme's role in CRC.

2025-12-20T00:00:00Z March-Yague, Aina Toledo, Diana Díaz, Asunción Godoy, Pere Pérez-Martínez, Olaia Pericas, Carles Sánchez-Migallón, Alonso Chirlaque-López, María-Dolores Ospina, Jesus Grau, María Roig, Francisco Dominguez, Ángela https://sms.carm.es/ricsmur/handle/123456789/25775 2026-04-06T11:22:08Z 2026-02-20T00:00:00Z

Mpox in people living with and without HIV, including people on PrEP, during a multistate outbreak in Spain in 2022. March-Yague, Aina; Toledo, Diana; Díaz, Asunción; Godoy, Pere; Pérez-Martínez, Olaia; Pericas, Carles; Sánchez-Migallón, Alonso; Chirlaque-López, María-Dolores; Ospina, Jesus; Grau, María; Roig, Francisco; Dominguez, Ángela Spain reported the highest cumulative incidence of mpox in Europe during the 2022 outbreak, which disproportionately affected people living with HIV (PLWH) and HIV-negative individuals using pre-exposure prophylaxis (PrEP). We conducted a multicentre cross-sectional study to analyze epidemiological, clinical, and disease progression characteristics of mpox among PLWH, HIV-negative individuals, and PrEP user cases and non-user cases in Spain. Data were collected from June 2022 to January 2023, including 1,158 men aged ? 18 years; 35.3% were PLWH and 42.7% of HIV-negative individuals were PrEP users. Adjusted OR and the 95% CI were calculated by multivariate logistic regression analysis. More frequently PLWH than HIV-negative cases were having sex only with men (aOR = 10.92;3.76-31.69), chemsex (aOR = 2.02;1.38-2.97), another type of immunosuppression (aOR = 2.57;1.07-6.21) and non-anogenital and non-oral exanthems (aOR = 1.64;1.23-2.19). More frequent in PLWH compared to PrEP user cases were lower education levels (aOR = 23.21;2.87-187.52), fever (aOR = 1.42;0.98-2.06), non-anogenital and non-oral exanthems (aOR = 2.40;1.67-3.45) and another type of immunosuppression (aOR = 9.32;1.16-75.16) and more frequent in PrEP user cases than in non-PrEP user cases were risk factors related to sexual activity and concurrent sexually transmitted infections. PLWH did not experience more severe mpox than HIV-negative persons. These findings underscore the need for tailored prevention and clinical approaches. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1038/s41598-026-37209-3.

2026-02-20T00:00:00Z Stein, Michael-J Baurecht, Hansjorg Bohmann, Patricia Córdova, Reynalda Ferrari, Pietro Fervers, Beatrice Friedenreich, Christine-M Gunter, Marc-J Peruchet-Noray, Laia Wu, Diana Onland-Moret, Charlotte Sánchez, María-José Chirlaque-López, María-Dolores Leitzmann, Michael-F Viallon, Vivian Freisling, Heinz https://sms.carm.es/ricsmur/handle/123456789/25731 2026-04-06T11:22:08Z 2026-03-13T00:00:00Z

Proteomics signature of moderate-to-vigorous physical activity and risk of multimorbidity of cancer and cardiometabolic diseases Stein, Michael-J; Baurecht, Hansjorg; Bohmann, Patricia; Córdova, Reynalda; Ferrari, Pietro; Fervers, Beatrice; Friedenreich, Christine-M; Gunter, Marc-J; Peruchet-Noray, Laia; Wu, Diana; Onland-Moret, Charlotte; Sánchez, María-José; Chirlaque-López, María-Dolores; Leitzmann, Michael-F; Viallon, Vivian; Freisling, Heinz BACKGROUND: Moderate-to-vigorous physical activity (MVPA) is inversely associated with risks of cancer, cardiovascular diseases (CVD), type 2 diabetes (T2D), and their co-occurrence, defined as multimorbidity; however, the underlying biological pathways remain unclear. METHODS: In 33,806 UK Biobank participants with 2911 measured blood proteins, a proteomic signature of MVPA was derived with linear and LASSO regressions. Multivariable Cox models, adjusted for MVPA, estimated prospective associations with cancer, CVD, T2D, and multimorbidity. RESULTS: We show that after multiple testing corrections, 220 proteins are retained in the MVPA signature. Proteins related to food intake, metabolism, and cell growth (e.g., LEP, MSTN) are inversely associated, while those involved in immune cell migration and musculoskeletal integrity (e.g., integrins, COMP) are positively associated with MVPA. Several proteins positively associated with MVPA are inversely associated with disease risk (e.g., integrins, CLEC4A for cancer; LPL, LEP for T2D), while proteins negatively associated with MVPA are positively associated with disease risk (e.g., CD38, TGFA for CVD). The proteomic signature score is inversely associated with cancer risk (hazard ratio per interquartile range: 0.87; 95% confidence interval: 0.78, 0.96) and T2D (0.66; 0.60, 0.72). For multimorbidity, proteins inversely related to MVPA align with expected risk patterns (e.g., GGT1, HR: 1.32; 95% CI: 1.12, 1.57), but the proteomic signature score is not associated. CONCLUSIONS: This study identifies several proteins associated with MVPA that are also associated with cancer, CVD, T2D, and the multimorbidity of these conditions. Further studies investigating the causal nature of these associations are welcome.

2026-03-13T00:00:00Z López-Padilla, María-Fernanda Seoane-Miraz, David Guinon-Fort, Daniel Almanza-Aguilera, Enrique Dahm, Christina-C Louati-Hajji, Mariem Cadeau, Claire Mancini, Francesca-Romana Bajracharya, Rashmita Katzke, Verena Schulze, Matthias-B Masala, Giovanna Agnoli, Claudia Signoriello, Simona Padroni, Lisa Lasheras, Cristina Sánchez, María-José Aizpurua-Atxega, Amaia Colorado-Yohar, Sandra Gasque, Alba Chan, Wing-Ching Saleh, Yahya-Mahamat Tjonneland, Anne Lill, Christina-M Farras, Marta Zamora-Ros, Raul https://sms.carm.es/ricsmur/handle/123456789/25697 2026-04-06T11:22:55Z 2026-03-09T00:00:00Z

Intake of the Total, Classes, and Subclasses of (Poly)phenols and Breast Cancer Risk: A Prospective Analysis of the EPIC Study. López-Padilla, María-Fernanda; Seoane-Miraz, David; Guinon-Fort, Daniel; Almanza-Aguilera, Enrique; Dahm, Christina-C; Louati-Hajji, Mariem; Cadeau, Claire; Mancini, Francesca-Romana; Bajracharya, Rashmita; Katzke, Verena; Schulze, Matthias-B; Masala, Giovanna; Agnoli, Claudia; Signoriello, Simona; Padroni, Lisa; Lasheras, Cristina; Sánchez, María-José; Aizpurua-Atxega, Amaia; Colorado-Yohar, Sandra; Gasque, Alba; Chan, Wing-Ching; Saleh, Yahya-Mahamat; Tjonneland, Anne; Lill, Christina-M; Farras, Marta; Zamora-Ros, Raul Polyphenols represent the largest and most diverse class of dietary antioxidants. Epidemiological evidence linking specific (poly)phenol classes, such as flavonoids and lignans, to breast cancer (BC) risk remains limited and largely inconclusive in prospective studies. The aim of this study is to examine the association between the intake of total (poly)phenols-and its classes and subclasses-and BC risk-overall and by subtypes (estrogen, progesterone, and human epidermal growth factor receptor 2 (HER2))-in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The EPIC cohort includes 257,960 adult women from seven European countries. During a mean follow-up of 14 years, there were 10,722 incident overall BC cases. Associations were computed using Cox regression models adjusted for potential confounders. No significant associations were found between total (poly)phenol intake and overall BC risk (HR(Q5 vs. Q1) = 1.02; 95% CI: 0.95-1.11). In addition, null associations were mostly found between classes and subclasses of (poly)phenols and BC subtypes. After stratifying by menopausal status, no significant associations were observed. In conclusion, this study found no evidence of associations between the intake of any class or subclass of (poly)phenols and BC risk in the European population.

2026-03-09T00:00:00Z