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Listar por tema "Gene Expression Regulation"

Listar por tema "Gene Expression Regulation"

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  • 7,8-Dihydroxiflavone Protects Adult Rat Axotomized Retinal Ganglion Cells through MAPK/ERK and PI3K/AKT Activation 
    Galindo-Romero, Caridad; Vidal-Villegas, Beatriz; Asis-Martínez, Javier; Lucas-Ruiz, Fernando; Gallego-Ortega, Alejandro; Vidal-Sanz, Manuel (MDPI, 2021-10)
    Unsuccessful wound closure in chronic wounds can be linked to altered keratinocyte activation and their inability to re-epithelize. Suggested mechanisms driving this impairment involve unbalanced cytokine signaling. However, ...
  • Age-induced differential changes in the central and colonic human circadian oscillators 
    Camello-Almaraz, Cristina; Martín-Cano, Francisco-E; Santos, Francisco-J; Espín, María-Teresa; Madrid, Juan-Antonio; Pozo, María-J; Camello, Pedro-J (MDPI AG, 2020)
    Aging modifies not only multiple cellular and homeostatic systems, but also biological rhythms. The circadian system is driven by a central hypothalamic oscillator which entrains peripheral oscillators, in both cases ...
  • An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages 
    López-Muñoz, Azucena; Nicolás, Francisco-E; García-Moreno, Diana; Pérez-Oliva, Ana-Belén; Navarro-Mendoza, María-I; Hernández-Onate, Miguel-A; Herrera-Estrella, Alfredo; Torres-Martínez, Santiago; Ruiz-Vázquez, Rosa-M; Garre, Victoriano; Mulero, Víctoriano (NATURE PORTFOLIO, 2018-08-24)
    Mucormycosis is a life-threatening fungal infection caused by various ubiquitous filamentous fungi of the Mucorales order, although Rhizopus spp. and Mucor spp. are the most prevalent causal agents. The limited therapeutic ...
  • Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status 
    Fedirko, Veronika; Jenab, Mazda; Meplan, Catherine; Jones, Jeb-S; Zhu, Wanzhe; Schomburg, Lutz; Siddiq, Afshan; Hybsier, Sandra; Overvad, Kim; Tjonneland, Anne; Omichessan, Hanane; Perduca, Vittorio; Boutron-Ruault, Marie-Christine; Kuehn, Tilman; Katzke, Verena; Aleksandrova, Krasimira; Trichopoulou, Antonia; Karakatsani, Anna; Kotanidou, Anastasia; Tumino, Rosario; Panico, Salvatore; Masala, Giovanna; Agnoli, Claudia; Naccarati, Alessio; Bueno-de-Mesquita, Bas; Vermeulen, Roel-C-H; Weiderpass, Elisabete; Skeie, Guri; Nost, Therese-Haugdahl; Lujan-Barroso, Leila; Quirós, José-Ramón; Huerta-Castaño, José-María; Rodríguez-Barranco, Miguel; Barricarte-Gurrea, Aurelio; Gylling, Bjoern; Harlid, Sophia; Bradbury, Kathryn-E; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc; Murphy, Neil; Freisling, Heinz; Tsilidis, Kostas; Aune, Dagfinn; Riboli, Elio; Hesketh, John-E; Hughes, David-J (MDPI, 2019-04)
    Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide ...
  • CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis 
    Alarcón-Vila, Cristina; Baroja-Mazo, Alberto; de-Torre-Minguela, Carlos; Martínez, Carlos-M; Martínez-García, Juan-José; Martínez-Banaclocha, Helios; García-Palenciano, Carlos; Pelegrín, Pablo (ELIFE SCIENCES PUBLICATIONS LTD, 2020-11)
    P2X7 receptor activation induces the release of different cellular proteins, such as CD14, a glycosylphosphatidylinositol (GPI)-anchored protein to the plasma membrane important for LPS signaling via TLR4. Circulating CD14 ...
  • Comprehensive comparison of neonate and adult human platelet transcriptomes 
    Caparros-Pérez, Eva; Teruel-Montoya, Raúl; López-Andreo, María-José; Carmen-Llanos, Ma; Rivera, José; Palma-Barqueros, Verónica; Blanco-Carnero, José-Eliseo; Vicente, Vicente; Martínez, Constantino; Ferrer-Marín, Francisca (PUBLIC LIBRARY SCIENCE, 2017-08-16)
    Understanding the underlying mechanisms of the well-substantiated platelet hyporeactivity in neonates is of interest given their implications for the clinical management of newborns, a population at higher bleeding risk ...
  • Extracellular NLRP3 inflammasome particles are internalized by human coronary artery smooth muscle cells and induce pro-atherogenic effects 
    Gaul, Susanne; Schaeffer, Karen-Marie; Opitz, Lena; Maeder, Christina; Kogel, Alexander; Uhlmann, Luisa; Kalwa, Hermann; Wagner, Ulf; Haas, Jan; Behzadi, Amirhossein; Pelegrín, Pablo; Boeckel, Jes-Niels; Laufs, Ulrich (NATURE PORTFOLIO, 2021-07)
    Inflammation driven by intracellular activation of the NLRP3 inflammasome is involved in the pathogenesis of a variety of diseases including vascular pathologies. Inflammasome specks are released into the extracellular ...
  • Formalization of gene regulation knowledge using ontologies and gene ontology causal activity models 
    Juanes-Cortes, Belén; Vera-Ramos, José-Antonio; Lovering, Ruth-C; Gaudet, Pascale; Laegreid, Astrid; Logie, Colin; Schulz, Stefan; Roldán-García, María-del-Mar; Kuiper, Martín; Fernández-Breis, Jesualdo-Tomás (ELSEVIER, 2021-11)
    Gene regulation computational research requires handling and integrating large amounts of heterogeneous data. The Gene Ontology has demonstrated that ontologies play a fundamental role in biological data interoperability ...
  • Identification of differentially expressed genes profiles in a combined mouse model of Parkinsonism and colitis 
    Gil-Martínez, Ana-Luisa; Cuenca-Bermejo, Lorena; González-Cuello, Ana-María; Sánchez-Rodrigo, C; Parrado, A; Vyas, S; Fernández-Villalba, Emiliano; Herrero, MT (NATURE PORTFOLIO, 2020-08-04)
    Different cellular mechanisms have been described as being potentially involved in the progression of neurodegeneration in Parkinson's disease, although their role is still unclear. The present study aimed to identify in ...
  • MicroRNAs as New Regulators of Neutrophil Extracellular Trap Formation 
    Águila, Sonia; de-los-Reyes-García, Ascensión-María; Fernández-Pérez, María-Piedad; Reguilón-Gallego, Laura; Zapata-Martínez, Laura; Ruiz-Lorente, Inmaculada; Vicente, Vicente; González-Conejero, Rocío; Martínez, Constantino (MDPI, 2021-02)
    Neutrophil extracellular traps (NETs) are formed after neutrophils expelled their chromatin content in order to primarily capture and eliminate pathogens. However, given their characteristics due in part to DNA and different ...
  • miR-146a deficiency in hematopoietic cells is not involved in the development of atherosclerosis 
    del-Monte, Alberto; Arroyo-Rodríguez, Ana-B; Andrés-Manzano, María-J; García-Barbera, Nuria; Caleprico, María-S; Vicente, Vicente; Roldán-Schilling, Vanessa; González-Conejero, Rocío; Martínez, Constantino; Andrés, Vicente (PUBLIC LIBRARY SCIENCE, 2018-06-14)
    BACKGROUND: Atherosclerosis involves activation of the IRAK1/TRAF6/NF-?B inflammatory cascade, which is negatively regulated by miR146a. Previous studies showed that the TT genotype of rs2431697, located near the miR-146a ...
  • Modifications in Gene Expression in the Process of Osteoblastic Differentiation of Multipotent Bone Marrow-Derived Human Mesenchymal Stem Cells Induced by a Novel Osteoinductive Porous Medical-Grade 3D-Printed Poly(e-caprolactone)/ß-tricalcium Phosphate C 
    López-González, Iván; Zamora-Ledezma, Camilo; Sánchez-Lorencio, María-Isabel; Tristante-Barrenechea, Elena; Gabaldón-Hernández, José-Antonio; Meseguer-Olmo, Luis (MDPI, 2021-10)
    In this work, we evaluated the influence of a novel hybrid 3D-printed porous composite scaffold based on poly(?-caprolactone) (PCL) and ?-tricalcium phosphate (?-TCP) microparticles in the process of adhesion, proliferation, ...
  • Populational heterogeneity and partial migratory origin of the ventromedial hypothalamic nucleus: genoarchitectonic analysis in the mouse 
    López-González, Lara; Martínez-de-la-Torre, Margaret; Puelles, Luis (Springer Heidelberg, 2023-03)
    The ventromedial hypothalamic nucleus (VMH) is one of the most distinctive hypothalamic tuberal structures, subject of numerous classic and modern functional studies. Commonly, the adult VMH has been divided in several ...
  • RNA expression changes driven by altered epigenetics status related to NASH etiology 
    Castellano-Castillo, Daniel; Ramos-Molina, Bruno; Frutos, María-Dolores; Arranz-Salas, Isabel; Reyes-Engel, Armando; Queipo-Ortuño, María-Isabel; Cardona, Fernando (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2024-05)
    Non-alcoholic fatty liver disease (NAFLD) is a growing health problem due to the increased obesity rates, among other factors. In its more severe stage (NASH), inflammation, hepatocellular ballooning and fibrosis are present ...
  • The gene regulation knowledge commons: the action area of GREEKC 
    Kuiper, Martín; Bonello, Joseph; Fernández-Breis, Jesualdo-Tomás; Bucher, Philipp; Futschik, Matthias-E; Gaudet, Pascale; VKulakovskiy, Ivan; Licata, Luana; Logie, Colin; Lovering, Ruth-C; Makeev, Vsevolod-J; Orchard, Sandra; Panni, Simona; Perfetto, Livia; Sant, David; Schulz, Stefan; Vercruysse, Steven; Zerbino, Daniel-R; Laegreid, Astrid (ELSEVIER, 2022-01)
    As computational modeling becomes more essential to analyze and understand biological regulatory mechanisms, governance of the many databases and knowledge bases that support this domain is crucial to guarantee reliability ...
  • The Role of Fatty Acids in Non-Alcoholic Fatty Liver Disease Progression: An Update 
    Hliwa, Aleksandra; Ramos-Molina, Bruno; Laski, Dariusz; Mika, Adriana; Sledzinski, Tomasz (MDPI, 2021-07)
    Non-alcoholic fatty liver disease (NAFLD) is a major public health problem worldwide. NAFLD (both simple steatosis and steatohepatitis) is characterized by alterations in hepatic lipid metabolism, which may lead to the ...