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Listar por tema "Gene Expression Profiling"

Listar por tema "Gene Expression Profiling"

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  • A Comparative View on the Oviductal Environment during the Periconception Period 
    González-Brusi, Leopoldo; Algarra, Blanca; Moros-Nicolás, Carla; Izquierdo-Rico, María-José; Avilés, Manuel; Jiménez-Movilla, María (MDPI, 2020-12)
    The GATA1 transcription factor is essential for normal erythropoiesis and megakaryocytic differentiation. Germline GATA1 pathogenic variants in the N-terminal zinc finger (N-ZF) are typically associated with X-linked ...
  • An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages 
    López-Muñoz, Azucena; Nicolás, Francisco-E; García-Moreno, Diana; Pérez-Oliva, Ana-Belén; Navarro-Mendoza, María-I; Hernández-Onate, Miguel-A; Herrera-Estrella, Alfredo; Torres-Martínez, Santiago; Ruiz-Vázquez, Rosa-M; Garre, Victoriano; Mulero, Víctoriano (NATURE PORTFOLIO, 2018-08-24)
    Mucormycosis is a life-threatening fungal infection caused by various ubiquitous filamentous fungi of the Mucorales order, although Rhizopus spp. and Mucor spp. are the most prevalent causal agents. The limited therapeutic ...
  • An Immune Dysfunction Signature Score Predicts Survival in MDS Patients: Insights From a Longitudinal, Multicenter Study 
    Wang, Yu-Hung; Gurnari, Carmelo; Visconte, Valeria; Durmaz, Arda; Guarnera, Luca; Lee, Wan-Hsuan; Yao, Chi-Yuan; Jerez-Cayuela, Andrés; Gurashi, Kristian; Batta, Kiran; Hou, Hsin-An; Chou, Wen-Chien; Patnaik, Mrinal-S; Maciejewski, Jaroslaw; Wiseman, Daniel-H; Lin, Chien-Chin; Tien, Hwei-Fang (WILEY, 2026-07)
    Myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) are clonal myeloid neoplasms shaped by genetic lesions and immune dysregulation, both of which contribute to disease progression and poor outcomes. ...
  • An MGRN1-Based Biomarker Combination Accurately Predicts Melanoma Patient Survival 
    Sánchez-Beltrán, José; Soler-Díaz, Javier; Herraiz-Serrano, Cecilia; Olivares, Conchi; Cerdido, Sonia; Cerezuela-Fuentes, Pablo; García-Borrón, Jose-Carlos; Jiménez-Cervantes, Celia (MDPI, 2025-02-18)
    With ever-increasing incidence and high metastatic potential, cutaneous melanoma is the deadliest skin cancer. Risk prediction based on the Tumor-Node-Metastasis (TNM) staging system has medium accuracy with intermediate ...
  • Comprehensive comparison of neonate and adult human platelet transcriptomes 
    Caparros-Pérez, Eva; Teruel-Montoya, Raúl; López-Andreo, María-José; Carmen-Llanos, Ma; Rivera, José; Palma-Barqueros, Verónica; Blanco-Carnero, José-Eliseo; Vicente, Vicente; Martínez, Constantino; Ferrer-Marín, Francisca (PUBLIC LIBRARY SCIENCE, 2017-08-16)
    Understanding the underlying mechanisms of the well-substantiated platelet hyporeactivity in neonates is of interest given their implications for the clinical management of newborns, a population at higher bleeding risk ...
  • Computational Prediction of Biomarkers, Pathways, and New Target Drugs in the Pathogenesis of Immune-Based Diseases Regarding Kidney Transplantation Rejection 
    Alfaro, Rafael; Martínez-Banaclocha, Helios; Llorente, Santiago; Llorente, Santiago; Jiménez-Coll, Víctor; Galián, José-Antonio; Botella, Carmen; Moya-Quiles, María-Rosa; Parrado, Antonio; Muro-Pérez, Manuel; Minguela-Puras, Alfredo; Legaz, Isabel; Muro, Manuel; Muro, Manuel (FRONTIERS MEDIA SA, 2021-12-15)
    BACKGROUND: The diagnosis of graft rejection in kidney transplantation (KT) patients is made by evaluating the histological characteristics of biopsy samples. The evolution of omics sciences and bioinformatics techniques ...
  • DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids 
    Cánovas, Sebastián; Ivanova, Elena; Romar, Raquel; García-Martínez, Soledad; Soriano-Úbeda, Cristina; García-Vazquez, Francisco-A; Saadeh, Heba; Andrews, Simon; Kelsey, Gavin; Coy-Fuster, Pilar (ELIFE SCIENCES PUBLICATIONS LTD, 2017-02-01)
    The number of children born since the origin of Assisted Reproductive Technologies (ART) exceeds 5 million. The majority seem healthy, but a higher frequency of defects has been reported among ART-conceived infants, ...
  • Effects of Vitrification on the Blastocyst Gene Expression Profile in a Porcine Model 
    Cuello, Cristina; Martínez, Cristina-A; Cambra, Josep-M; Parrilla, Inmaculada; Rodríguez-Martínez, Heriberto; Gil, María-A; Martínez, Emilio-A (MDPI, 2021-02)
    This study was designed to investigate the impact of vitrification on the transcriptome profile of blastocysts using a porcine (Sus scrofa) model and a microarray approach. Blastocysts were collected from weaned sows (n = ...
  • Pseudozyma Priming Influences Expression of Genes Involved in Metabolic Pathways and Immunity in Zebrafish Larvae 
    Siriyappagouder, Prabhugouda; Galindo-Villegas, Jorge; Dhanasiri, Anusha-K-S; Zhang, Qirui; Mulero, Victoriano; Kiron, Viswanath; Fernandes, Jorge-M-O (FRONTIERS MEDIA SA, 2020-05-22)
    Fungi, particularly yeasts, are known essential components of the host microbiota but their functional relevance in development of immunity and physiological processes of fish remains to be elucidated. In this study, we ...
  • RNA sequencing-based transcriptome profiling of cardiac tissue implicates novel putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy 
    Hall, Charlotte-L; Gurha, Priyatansh; Sabater-Molina, María; Asimaki, Ángeliki; Futema, Marta; Lovering, Ruth-C; Suárez, Mari-Paz; Aguilera, Beatriz; Molina, Pilar; Zorio, Esther; Coarfa, Cristian; Robertson, Matthew-J; Cheedipudi, Sirisha-M; Ng, Keat-eng; Delaney, Paul; Hernández, Juan-Pedro; Pastor, Francisco; Gimeno, Juan-R; McKenna, William-J; Marian, Ali-J; Syrris, Petros (ELSEVIER IRELAND LTD, 2020-03-01)
    Arrhythmogenic cardiomyopathy (ACM) encompasses a group of inherited cardiomyopathies including arrhythmogenic right ventricular cardiomyopathy (ARVC) whose molecular disease mechanism is associated with dysregulation of ...
  • Seminal Plasma Induces Overexpression of Genes Associated with Embryo Development and Implantation in Day-6 Porcine Blastocysts 
    Martínez, Cristina-A; Cambra, Josep-M; Gil, María-A; Parrilla, Inmaculada; Álvarez-Rodríguez, Manuel; Rodríguez-Martínez, Heriberto; Cuello, Cristina; Martínez, Emilio-A (MDPI, 2020-05)
    The infusion of boar seminal plasma (SP) before artificial insemination (AI) positively alters the expression of endometrial genes and pathways involved in embryo development. This study aimed to determine which transcriptome ...
  • The expression of immune response genes in patients with chronic Chagas disease is shifted toward the levels observed in healthy subjects as a result of treatment with Benznidazole 
    Gómez, Inmaculada; Egui, Adriana; Palacios, Genesis; Carrilero, Bartolomé; Benítez, Celia; Simón, Marina; Segovia, Manuel; Carmelo, Emma; López, Manuel-Carlos; Thomas, M-Carmen (FRONTIERS MEDIA SA, 2024-07)
    INTRODUCTION: Chagas disease, caused by the Trypanosoma cruzi parasite infection, is a potentially life-threatening neglected tropical disease with a worldwide distribution. During the chronic phase of the disease, there ...
  • The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination 
    Crosas-Molist, E; Bertran, E; Rodríguez-Hernández, I; Herraiz, C; Cantelli, G; Fabra, A; Sanz-Moreno, V; Fabregat, I (NATURE PUBLISHING GROUP, 2017-05-25)
    Epithelial to mesenchymal transition is a common event during tumour dissemination. However, direct epithelial to amoeboid transition has not been characterized to date. Here we provide evidence that cells from hepatocellular ...
  • Transcriptomic Analysis Corroborates the New Radial Model of the Mouse Pallial Amygdala 
    Fernández, Gloria; López-González, Lara; Pons-Fuster, Eduardo; Puelles, Luis; García-Calero, Elena (MDPI, 2025-08-13)
    The mammalian amygdala is located in the temporal lobe of the telencephalon and plays a key role in limbic processing. Recently, our group proposed a radial morphological model to understand the glutamatergic (pallial) ...