Repositorio Dspace

Listar por autor "O'Donnell, James-S"

Listar por autor "O'Donnell, James-S"

Ordenar por:Orden:Resultados:

  • The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1 
    Chion, Alain; Byrne, Ciara; Atiq, Ferdows; Doherty, Dearbhla; Águila, Sonia; Fazavana, Judicael; Lopes, Patricia; Karampini, Ellie; Amin, Aamir; Preston, Roger-JS; Baker, Ross-I; Mckinnon, Thomas-AJ; Zhu, Shuhao; Gilbert, James-C; Emsley, Jonas; Jilma, Bernd; O'Donnell, James-S (ELSEVIER, 2024-09)
    Rondaptivon pegol (previously BT200) is a pegylated RNA aptamer that binds to the A1 domain of von Willebrand factor (VWF). Recent clinical trials demonstrated that BT200 significantly increased plasma VWF-factor VIII ...
  • von Willebrand factor links primary hemostasis to innate immunity 
    Drakeford, Clive; Águila, Sonia; Roche, Fiona; Hokamp, Karsten; Fazavana, Judicael; Cervantes, Mariana-P; Curtis, Annie-M; Hawerkamp, Heike-C; Dhami, Sukhraj-Pal-Singh; Charles-Messance, Hugo; Hackett, Emer-E; Chion, Alain; Ward, Soracha; Ahmad, Azaz; Schoen, Ingmar; Breen, Eamon; Keane, Joe; Murphy, Ross; Preston, Roger-JS; O'Sullivan, Jamie-M; Sheedy, Frederick-J; Fallon, Padraic; O'Donnell, James-S (NATURE PORTFOLIO, 2022-11)
    The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary hemostasis by tethering platelets to exposed collagen at sites of vascular injury. Recent studies have identified additional ...