Repositorio Dspace

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  • A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review 
    Garrigos,Daniel; Martinez-Morga,Marta; Toval,Angel; Kutsenko,Yevheniy; Barreda,Alberto; Do-Couto,Bruno-Ribeiro; Navarro-Mateu,Fernando; Luis-Ferran,Jose (FRONTIERS MEDIA SA, 2021)
    Purpose: To identify and characterize numerically and topographically the population of alpha retinal ganglion cells (alpha RGCs) and their subtypes, the sustained-response ON-center alpha RGCs (ONs-alpha RGCs), which ...
  • A knowledge graph-based data harmonization framework for secondary data reuse 
    Abad-Navarro,Francisco; Martinez-Costa,Catalina (ELSEVIER IRELAND LTD, 2024-01)
    Background and objective: The adoption of new technologies in clinical care systems has propitiated the availability of a great amount of valuable data. However, this data is usually heterogeneous, requiring its harmonization ...
  • A Meta-Analysis of the Reliability of Four Field-Based Trunk Extension Endurance Tests 
    Martínez-Romero, María-Teresa; Ayala, Francisco; De-Ste-Croix, Mark; Vera-García, Francisco-J; Sainz-de-Baranda, Pilar; Santonja-Medina, Fernando; Sánchez-Meca, Julio (MDPI, 2020-05)
    This meta-analysis aimed to estimate the inter- and intra-tester reliability of endurance measures obtained through trunk extension field-based tests and to explore the influence of the moderators on the reliability ...
  • A methodology based on Trace-based clustering for patient phenotyping 
    Lopez-Martinez-Carrasco,Antonio; Juarez,Jose-M; Campos,Manuel; Canovas-Segura,Bernardo (ELSEVIER, 28/11/2021)
    Background: The current situation of critical progression as regards the resistance of bacteria to antibiotics has led to the use of machine learning techniques in order to provide clinicians with new knowledge for decision ...
  • A micro-CT evaluation of bone density around two different types of surfaces on one-piece fixo implants with early loading-an experimental study in dogs at 3 months 
    Calvo-Guirado,Jose-Luis; Carrillo,Nuria-Garcia; de-Carlos-Villafranca,Felix; Garces-Villala,Miguel-Angel; Mahesh,Lanka; Ibanez,Juan-Carlos; Martinez-Martinez,Francisco (AMER INST MATHEMATICAL SCIENCES-AIMS, 2022)
  • A Multi-Target Pharmacological Correction of a Lipoyltransferase LIPT1 Gene Mutation in Patient-Derived Cellular Models 
    Gomez-Fernandez,David; Romero-Gonzalez,Ana; Suarez-Rivero,Juan-M; Cilleros-Holgado,Paula; Alvarez-Cordoba,Monica; Pinero-Perez,Rocio; Romero-Dominguez,Jose-Manuel; Reche-Lopez,Diana; Lopez-Cabrera,Alejandra; Ibanez-Mico,Salvador; de-Oliveira,Marta-Castro| (MDPI, 2024-08)
    Simple Summary Cardiovascular diseases represent the leading cause of mortality and morbidity worldwide, and age is an important contributing factor. Preclinical models are crucial for exploring and understanding the ...
  • A Multicentre Study of the Attitude of Medical Students towards Organ Donation and Transplantation in Poland 
    Mikla,Marzena; Cybulska,Anna-Maria; Schneider-Matyka,Daria; Ríos,Antonio; Panczyk,Mariusz; Kotwas,Artur; Karakiewicz,Beata; Grochans,El¿biet (MDPI, 2023)
    To analyze the neuroprotective effects of 7,8-Dihydroxyflavone (DHF) in vivo and ex vivo, adult albino Sprague-Dawley rats were given a left intraorbital optic nerve transection (IONT) and were divided in two groups: One ...
  • A multicriteria decision analysis (MCDA) applied to three long-term prophylactic treatments for hereditary angioedema in Spain 
    Zozaya,Neboa; Caballero,Teresa; Gonzalez-Quevedo,Teresa; Gamboa-Setien,Pedro; Angeles-Gonzalez,Ma; Jodar,Ramon; Luis-Poveda-Andres,Jose; Guillen-Navarro,Encarna; Cuadrado,Agustin-Rivero; Hidalgo-Vega,Alvaro (ABOUTSCIENCE SRL, 25/01/2022)
    Introduction: Hereditary angioedema (HAE) is a rare genetic disease that impairs quality of life and could be life-threatening. The aim of this study was to apply a multicriteria decision analysis to assess the value of ...
  • A multimodal approach to detect and monitor early lung disease in cystic fibrosis 
    Mondejar-Lopez,Pedro; Horsley,Alexander; Ratjen,Felix; Bertolo,Silvia; de-Vicente,Helene; Asensio-de-la-Cruz,Oscar (TAYLOR & FRANCIS LTD, 03/06/2021)
    Introduction: In the early stages, lung involvement in cystic fibrosis (CF) can be silent, with disease progression occurring in the absence of clinical symptoms. Irreversible airway damage is present in the early stages ...
  • A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent 
    Bonelli,Joaquin; Ortega-Forte,Enrique; Vigueras,Gloria; Follana-Berna,Jorge; Ashoo,Pezhman; Abad-Montero,Diego; Isidro,Neus; Lopez-Corrales,Marta; Hernandez,Adrian; Ortiz,Javier; Izquierdo-Garcia,Eduardo; Bosch,Manel; Rocas,Josep; Sastre-Santos,Angela; Ru (AMER CHEMICAL SOC, 23/07/2024)
    Despite the potential of photodynamic therapy (PDT) in cancer treatment, the development of efficient and photostable photosensitizing molecules that operate at long wavelengths of light has become a major hurdle. Here, ...
  • A near-infrared light-activatable Ru(ii)-coumarin photosensitizer active under hypoxic conditions 
    Ortega-Forte,Enrique; Rovira,Anna; Lopez-Corrales,Marta; Hernandez-Garcia,Alba; Ballester,Francisco-Jose; Izquierdo-Garcia,Eduardo; Jorda-Redondo,Mireia; Bosch,Manel; Nonell,Santi; Santana,Maria-Dolores; Ruiz,Jose; Marchan,Vicente; Gasser,Gilles (ROYAL SOC CHEMISTRY, 2023)
    Photodynamic therapy (PDT) represents a promising approach for cancer treatment. However, the oxygen dependency of PDT to generate reactive oxygen species (ROS) hampers its therapeutic efficacy, especially against hypoxic ...
  • A new blood DNA methylation signature for Koolen-de Vries syndrome: Classification of missense KANSL1 variants and comparison to fibroblast cells 
    Awamleh,Zain; Choufani,Sanaa; Wu,Wendy; Rots,Dmitrijs; Dingemans,Alexander-J-M; Khadri,Nael-Nadif; Boronat,Susana; Ibanez-Mico,Salvador; Herraiz,Laura-Cuesta; Ferrer,Irene; Carrascal,Antonio-Martinez; Perez-Jurado,Luis-A; Lain,Gemma-Aznar; Ortigoza-Escoba (SPRINGERNATURE, 2024-03)
    Pathogenic variants in KANSL1 and 17q21.31 microdeletions are causative of Koolen-de Vries syndrome (KdVS), a neurodevelopmental syndrome with characteristic facial dysmorphia. Our previous work has shown that syndromic ...
  • A New Comorbidity in Periodontitis: Fusobacterium nucleatum and Colorectal Cancer 
    Mesa,Francisco; Mesa-Lopez,Maria-Jose; Egea-Valenzuela,Juan; Benavides-Reyes,Cristina; Nibali,Luigi; Ide,Mark; Mainas,Giuseppe; Rizzo,Manfredi; Magan-Fernandez,Antonio (MDPI, 2022-04)
    3,4,5-Trimethoxybenzoate of catechin (TMBC) is a semisynthetic catechin which shows strong antiproliferative activity against malignant melanoma cells. The amphiphilic nature of the molecule suggests that the membrane could ...
  • A New Pipeline for the Normalization and Pooling of Metabolomics Data 
    Viallon,Vivian; His,Mathilde; Rinaldi,Sabina; Breeur,Marie; Gicquiau,Audrey; Hemon,Bertrand; Overvad,Kim; Tjonneland,Anne; Rostgaard-Hansen,Agnetha-Linn; Rothwell,Joseph-A; Lecuyer,Lucie; Severi,Gianluca; Kaaks,Rudolf; Johnson,Theron; Schulze,Matthias-B (MDPI, 2021-09)
    Nanomaterials have unique properties and characteristics derived from their shape and small size that are not present in bulk materials. If size and shape are decisive, the synthesis method used, which determines the above ...
  • A new prognostic model including immune biomarkers, genomic proliferation tumor markers (AURKA and MYBL2) and clinical-pathological features optimizes prognosis in neoadjuvant breast cancer patients 
    Garcia-Torralba,Esmeralda; Navarro-Manzano,Esther; Luengo-Gil,Gines; Barrio,Pilar-De-la-Morena; Benito,Asuncion-Chaves; Perez-Ramos,Miguel; Alvarez-Abril,Beatriz; Rubio,Alejandra-Ivars; Garcia-Garre,Elisa; de-la-Pena,Francisco-Ayala; Garcia-Martinez,Elena (FRONTIERS MEDIA SA, 2023)
    Mutations in the lipoyltransferase 1 (LIPT1) gene are rare inborn errors of metabolism leading to a fatal condition characterized by lipoylation defects of the 2-ketoacid dehydrogenase complexes causing early-onset seizures, ...
  • A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia 
    Arriazu, Elena; Vicente, Carmen; Pippa, Raffaella; Peris, Irene; Martínez-Balsalobre, Elena; García-Ramírez, Patricia; Marcotegui, Nerea; Igea, Ana; Alignani, Diego; Rifon, José; Mateos, María-C; Cayuela, María-Luisa; Nebreda, Ángel-R; Odero, María-D (NATURE PUBLISHING GROUP, 2020-01-08)
    Acute myeloid leukemia (AML) is an aggressive hematologic malignancy. Although novel emerging drugs are available, the overall prognosis remains poor and new therapeutic approaches are required. PP2A phosphatase is a key ...
  • A New Technique for Computed-Tomography Urethrography in Males: The Clamp Method 
    de-Dios-Berna-Mestre,Juan; Guzman-Aroca,Florentina; Puerta-Sales,Alejandro; Navarro-Bano,Antonio; Carbonell-Lopez-del-Castillo,Guillermo; de-Dios-Berna-Serna,Juan; Alcaraz,Miguel (MDPI, 2021-02)
    The oviduct plays important roles in reproductive events: sperm reservoir formation, final gamete maturation, fertilization and early embryo development. It is well known that the oviductal environment affects gametes and ...
  • A New Therapeutic Application of Platelet-Rich Plasma to Chronic Breast Wounds: A Prospective Observational Study 
    de-Dios-Berna-Serna,Juan; Guzman-Aroca,Florentina; Garcia-Vidal,Jose-A; Hernandez-Gomez,Dolores; Azahara-Garcia-Ortega,Ana; Chivato-Martin-Falquina,Tomas; Pinero-Madrona,Antonio; de-Dios-Berna-Mestre,Juan (MDPI, 2020-10)
    Pooling metabolomics data across studies is often desirable to increase the statistical power of the analysis. However, this can raise methodological challenges as several preanalytical and analytical factors could introduce ...
  • A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity 
    Cuenca-Bermejo,Lorena; Pizzichini,Elisa; Goncalves,Valeria-C; Guillen-Diaz,Maria; Aguilar-Monino,Elena; Sanchez-Rodrigo,Consuelo; Gonzalez-Cuello,Ana-Maria; Fernandez-Villalba,Emiliano; Herrero,Maria-Trinidad (MDPI, 2021-05)
    We report a neonatal patient with hypertrophic cardiomyopathy (HCM), lactic acidosis and isolated complex I deficiency. Using a customized next-generation sequencing panel, we identified a novel hemizygous variant c.338G>A ...
  • A New Treatment for Mammillary Fistulas Using Ultrasound-Guided Percutaneous Needle Electrolysis 
    Berna-Serna, Juan-de-Dios; García-Vidal, José-Antonio; Escolar-Reina, María-P; Medina-Mirapeix, Francesc; Guzman-Aroca, Florentina; Piñero-Madrona, Antonio; Berna-Mestre, Juan-de-Dios (MDPI, 2020-03)
    The aim of this study was to investigate the efficacy of ultrasound-guided percutaneous needle electrolysis (PNE) in mammillary fistulas (MFs). A prospective study was performed in 18 patients with MF who were treated with ...