Repositorio Dspace

Listar por título

Listar por título

Ordenar por:Orden:Resultados:

  • A crowdsourcing database for the copy-number variation of the Spanish population 
    Lopez-Lopez,Daniel; Roldan,Gema; Fernandez-Rueda,Jose; Bostelmann,Gerrit; Carmona,Rosario; Aquino,Virginia; Perez-Florido,Javier; Ortuno,Francisco; Pita,Guillermo; Nunez-Torres,Rocio; Gonzalez-Neira,Anna; Pena-Chilet,Maria; Dopazo,Joaquin (BMC, 09/03/2023)
    Background Despite being a very common type of genetic variation, the distribution of copy-number variations (CNVs) in the population is still poorly understood. The knowledge of the genetic variability, especially at the ...
  • A decade of changes in management of immune thrombocytopenia, with special focus on elderly patients 
    Lozano-Almela, María-Luisa; Mingot-Castellano, María-Eva; Perera, María-M; Jarque, Isidro; Campos-Álvarez, Rosa-M; González-López, Tomás-J; Carreño-Tarragona, Gonzalo; Bermejo, Nuria; López-Fernández, María-F; de-Andres, Aurora; Valcárcel, David; Casado-Montero, Luis-Felipe; Álvarez-R, (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2021-02)
    Background: Ten years after their availability, thrombopoietin receptor agonists (TPO-RA) have heralded a paradigm shift in the treatment of immune thrombocytopenia (ITP). This study was aimed to analyze the implementation ...
  • A Delphi Study on the Management of Neuropathic Cancer Pain in Spain: The DOLNEO Study 
    Pérez-Hernández, Concepción; Cánovas, María-Luz; Carmona-Bayonas, Alberto; Escobar, Yolanda; Margarit-Ferri, César; Mulero-Cervantes, Juan-Francisco; Quintanar-Verdúguez, Teresa; Ancor-Serrano-Alfonso, Andrés; Virizuela, Juan (DOVE MEDICAL PRESS LTD, 2022)
    Purpose: The objectives of this project were to assess the current situation and management of cancer-related neuropathic pain (CRNP) in Spain and to provide specific recommendations for the assessment, diagnosis and ...
  • A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin 
    Moura,David-S; Pena-Chilet,Maria; Cordero-Varela,Juan-Antonio; Alvarez-Alegret,Ramiro; Agra-Pujol,Carolina; Izquierdo,Francisco; Ramos,Rafael; Ortega-Medina,Luis; Martin-Davila,Francisco; Castilla-Ramirez,Carolina; Nieves-Hernandez-Leon,Carmen; Romagosa,C (WILEY, 2021-12)
    Predictive biomarkers of trabectedin represent an unmet need in advanced soft-tissue sarcomas (STS). DNA damage repair (DDR) genes, involved in homologous recombination or nucleotide excision repair, had been previously ...
  • A fast, cost-saving and sensitive method for determination of cefuroxime in plasma by HPLC with ultraviolet detection 
    Hernandis,Veronica; Escudero,Elisa; Pareja,Ana; Marin,Pedro (WILEY, 2021-10)
    Cefuroxime (CFX) is a broad-spectrum second-generation cephalosporin and one of the best choices for antibiotic prophylaxis. However, when used in critically ill patients, it may present changes in its pharmacokinetic ...
  • A first-year melon/cowpea intercropping system improves soil nutrients and changes the soil microbial community 
    Cuartero, Jessica; Antonio-Pascual, José; Vivo, Juana-María; Ozbolat, Onurcan; Sánchez-Navarro, Virginia; Egea-Cortines, Marcos; Zornoza, Raul; Martínez-Mena, María; García, Eloisa; Ros, Margarita (ELSEVIER, 15/04/2022)
    The melon/cowpea intercropping system can be a specific and efficient cropping pattern in a horticultural field. Intercropping systems contribute to the optimization of land use, fostering sustainable and efficient ...
  • A Generator of Bivariate Distributions: Properties, Estimation, and Applications 
    Franco, Manuel; Vivo, Juana-María; Kundu, Debasis (MDPI, 2020-10)
    Hypertension is an important factor of cardiovascular diseases and contributes to their negative consequences including mortality. The World Health Organization estimated that 54% of strokes and 47% of cases of ischemic ...
  • A Genome-Wide Association Study on Liver Stiffness Changes during Hepatitis C Virus Infection Cure 
    Corma-Gomez,Anais; Macias,Juan; Rivero,Antonio; Rivero-Juarez,Antonio; de-los-Santos,Ignacio; Reus-Banuls,Sergio; Morano,Luis; Merino,Dolores; Palacios,Rosario; Galera,Carlos; Fernandez-Fuertes,Marta; Gonzalez-Serna,Alejandro; de-Rojas,Itziar; Ruiz,Agusti (MDPI, 2021-08)
    The diurnal rodent Octodon degus (O. degus) is considered an attractive natural model for Alzheimer's disease and other human age-related features. However, it has not been explored so far if the O. degus could be used as ...
  • A Growth Modulation Index-Based GEISTRA Score as a New Prognostic Tool for Trabectedin Efficacy in Patients with Advanced Soft Tissue Sarcomas: A Spanish Group for Sarcoma Research (GEIS) Retrospective Study 
    Martinez-Trufero,Javier; Miguel-De-Sande-Gonzalez,Luis; Luna,Pablo; Martin-Broto,Javier; Alvarez,Rosa; Marquina,Gloria; Diaz-Beveridge,Roberto; Poveda,Andres; Maria-Cano,Juana; Cruz-Jurado,Josefina; Lopez-Pousa,Antonio; Vaz-Salgado,Maria-Angeles; Valverde (MDPI, 2021-02)
    Swallowing a whole toothbrush is a rare event. As of today, no case described has documented that the foreign body has passed through the entire gastrointestinal tract and has been spontaneously eliminated. Places where ...
  • A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review 
    Garrigos, Daniel; Martínez-Morga, Marta; Toval, Ángel; Kutsenko, Yevheniy; Barreda, Alberto; Do-Couto, Bruno-Ribeiro; Navarro-Mateu, Fernando; Luis-Ferran, Jose (FRONTIERS MEDIA SA, 2021)
    Purpose: To identify and characterize numerically and topographically the population of alpha retinal ganglion cells (alpha RGCs) and their subtypes, the sustained-response ON-center alpha RGCs (ONs-alpha RGCs), which ...
  • A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve 
    Siguero-Álvarez, Marcos; Salguero-Jiménez, Alejandro; Grego-Bessa, Joaquim; de-la-Barrera, Jorge; MacGrogan, Donal; Prados, Belén; Sánchez-Saez, Fernando; Pineiro-Sabaris, Rebeca; Felipe-Medina, Natalia; Torroja, Carlos; Gómez, Manuel-José; Sabater-Molina, María; Escriba, Ruben; Richaud-Patin, Ivonne; Iglesias-García, Olalla; Sbroggio, Mauro; Callejas, Sergio; O'Regan, Declan-P; McGurk, Kathryn-A; Dopazo, Ana; Giovinazzo, Giovanna; Ibáñez, Borja; Monserrat, Lorenzo; Pérez-Pomares, José-María; Sánchez-Cabo, Fatima; Pendas, Alberto-M; Raya, Ángel; Gimeno-Blanes, Juan-R; de-la-Pompa, José-Luis (LIPPINCOTT WILLIAMS & WILKINS, 2023-01-03)
    BACKGROUND: The complex genetics underlying human cardiac disease is evidenced by its heterogenous manifestation, multigenic basis, and sporadic occurrence. These features have hampered disease modeling and mechanistic ...
  • A knowledge graph-based data harmonization framework for secondary data reuse 
    Abad-Navarro, Francisco; Martínez-Costa, Catalina (ELSEVIER IRELAND LTD, 2024-01)
    Background and objective: The adoption of new technologies in clinical care systems has propitiated the availability of a great amount of valuable data. However, this data is usually heterogeneous, requiring its harmonization ...
  • A Meta-Analysis of the Reliability of Four Field-Based Trunk Extension Endurance Tests 
    Martínez-Romero, María-Teresa; Ayala, Francisco; De-Ste-Croix, Mark; Vera-García, Francisco-J; Sainz-de-Baranda, Pilar; Santonja-Medina, Fernando; Sánchez-Meca, Julio (MDPI, 2020-05)
    This meta-analysis aimed to estimate the inter- and intra-tester reliability of endurance measures obtained through trunk extension field-based tests and to explore the influence of the moderators on the reliability ...
  • A methodology based on Trace-based clustering for patient phenotyping 
    López-Martínez-Carrasco, Antonio; Juarez, José-M; Campos, Manuel; Canovas-Segura, Bernardo (ELSEVIER, 28/11/2021)
    Background: The current situation of critical progression as regards the resistance of bacteria to antibiotics has led to the use of machine learning techniques in order to provide clinicians with new knowledge for decision ...
  • A micro-CT evaluation of bone density around two different types of surfaces on one-piece fixo implants with early loading-an experimental study in dogs at 3 months 
    Calvo-Guirado,Jose-Luis; Carrillo,Nuria-Garcia; de-Carlos-Villafranca,Felix; Garces-Villala,Miguel-Angel; Mahesh,Lanka; Ibanez,Juan-Carlos; Martinez-Martinez,Francisco (AMER INST MATHEMATICAL SCIENCES-AIMS, 2022)
  • A Multi-Target Pharmacological Correction of a Lipoyltransferase LIPT1 Gene Mutation in Patient-Derived Cellular Models 
    Gomez-Fernandez,David; Romero-Gonzalez,Ana; Suarez-Rivero,Juan-M; Cilleros-Holgado,Paula; Alvarez-Cordoba,Monica; Pinero-Perez,Rocio; Romero-Dominguez,Jose-Manuel; Reche-Lopez,Diana; Lopez-Cabrera,Alejandra; Ibanez-Mico,Salvador; de-Oliveira,Marta-Castro| (MDPI, 2024-08)
    Simple Summary Cardiovascular diseases represent the leading cause of mortality and morbidity worldwide, and age is an important contributing factor. Preclinical models are crucial for exploring and understanding the ...
  • A Multicentre Study of the Attitude of Medical Students towards Organ Donation and Transplantation in Poland 
    Mikla, Marzena; Cybulska, Anna-María; Schneider-Matyka, Daria; Ríos, Antonio; Panczyk, Mariusz; Kotwas, Artur; Karakiewicz, Beata; Grochans, El¿biet (MDPI, 2023)
    To analyze the neuroprotective effects of 7,8-Dihydroxyflavone (DHF) in vivo and ex vivo, adult albino Sprague-Dawley rats were given a left intraorbital optic nerve transection (IONT) and were divided in two groups: One ...
  • A multicriteria decision analysis (MCDA) applied to three long-term prophylactic treatments for hereditary angioedema in Spain 
    Zozaya, Neboa; Caballero, Teresa; González-Quevedo, Teresa; Gamboa-Setien, Pedro; Ángeles-González, Ma; Jodar, Ramón; Luis-Poveda-Andres, José; Guillén-Navarro, Encarna; Cuadrado, Agustín-Rivero; Hidalgo-Vega, Álvaro (ABOUTSCIENCE SRL, 25/01/2022)
    Introduction: Hereditary angioedema (HAE) is a rare genetic disease that impairs quality of life and could be life-threatening. The aim of this study was to apply a multicriteria decision analysis to assess the value of ...
  • A multimodal approach to detect and monitor early lung disease in cystic fibrosis 
    Mondejar-Lopez,Pedro; Horsley,Alexander; Ratjen,Felix; Bertolo,Silvia; de-Vicente,Helene; Asensio-de-la-Cruz,Oscar (TAYLOR & FRANCIS LTD, 03/06/2021)
    Introduction: In the early stages, lung involvement in cystic fibrosis (CF) can be silent, with disease progression occurring in the absence of clinical symptoms. Irreversible airway damage is present in the early stages ...
  • A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent 
    Bonelli, Joaquín; Ortega-Forte, Enrique; Vigueras, Gloria; Follana-Berna, Jorge; Ashoo, Pezhman; Abad-Montero, Diego; Isidro, Neus; López-Corrales, Marta; Hernández, Adrian; Ortiz, Javier; Izquierdo-García, Eduardo; Bosch, Manel; Rocas, Josep; Sastre-Santos, Ángela; Ru (AMER CHEMICAL SOC, 23/07/2024)
    Despite the potential of photodynamic therapy (PDT) in cancer treatment, the development of efficient and photostable photosensitizing molecules that operate at long wavelengths of light has become a major hurdle. Here, ...