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  • Drug-drug interactions in patients undergoing hematopoietic stem cell transplantation: systematic review 
    Sáez-Garrido, María; Espuny-Miró, Alberto; Ruiz-Gómez, Agustina; Díaz-Carrasco, María-Sacramento (ELSEVIER, 2021-06-03)
    OBJECTIVE: The present paper provides a systematic review aimed at identifying studies on pharmacological interactions in patients  undergoing hematopoietic stem cell transplantation. Secondary objectives  include ...
  • Dry Needling Alone or in Combination with Exercise Therapy versus Other Interventions for Reducing Pain and Disability in Subacromial Pain Syndrome: A Systematic Review and Meta-Analysis 
    Para-García, Gonzalo; García-Muñoz, Ana-María; Francisco-López-Gil, José; Diego-Ruiz-Cárdenas, Juan; Isabel-García-Guillén, Ana; López-Román, Francisco-Javier; Pérez-Piñero, Silvia; Salud-Abellán-Ruiz, María; Cánovas, Fernando; Victoria-Montesinos, Desiree (MDPI, 2022-09)
    This systematic review and meta-analysis examined the effects of dry needling alone or in combination with exercise therapy for reducing pain and disability in people with subacromial pain syndrome. Systematic searches of ...
  • Dual Immunotherapy for Pericardial Mesothelioma That Developed After a Decade-Long Idiopathic Pericarditis: A Case Report 
    Grau-Mirete, Beatriz; Rodríguez-Payá, Paula; Martínez-Marín, Mariano; Fernández-Arias, Asia; Borregón-Rivilla, Miguel; Lázaro-Sánchez, Antonio-David; Morillas-Blasco, Pedro; Rodríguez-Lescure, Álvaro; Benítez-Fuentes, Javier-David (WILEY, 2025-05)
    Malignant pericardial mesothelioma (MPeM) is exceptionally rare, and its association with long-standing idiopathic pericarditis remains unreported. We present a 46-year-old woman with a decade-long history of recurrent ...
  • Dual latent tuberculosis screening with tuberculin skin tests and QuantiFERON-TB assays before TNF-¿ inhibitor initiation in children in Spain 
    Calzada-Hernández, Joan; Antón, Jordi; Martín-de-Carpi, Javier; López-Montesinos, Berta; Calvo, Inmaculada; Donat, Ester; Núñez, Esmeralda; Blasco-Alonso, Javier; Mellado, María-José; Baquero-Artigao, Fernando; Leis, Rosaura; Vegas-Álvarez, Ana-María; Medrano-San-Ildefonso, Marta; del-Carmen-Pinedo-Gago, María; Eizaguirre, Francisco-Javier; Tagarro, Alfredo; Camacho-Lovillo, Marisol; Pérez-Gorricho, Beatriz; GÁvilan-Martín, César; Guillen, Sara; Sevilla-Pérez, Belen; Pena-Quintana, Luis; Mesa-del-Castillo, Pablo; Fortuny, Claudia; Tebruegge, Marc; Noguera-Julián, Antoni (Springer, 2023-01)
    Tumor-necrosis-factor-¿ inhibitors (anti-TNF-¿) are associated with an increased risk of tuberculosis (TB) disease, primarily due to reactivation of latent TB infection (LTBI). We assessed the performance of parallel LTBI ...
  • Dual role of ACE2 in regulating inflammation triggered by Omicron S1 and other SARS-CoV-2 Spike variants 
    Pedoto, AnnaMaría; Lozano-Gil, Juan-Manuel; Ocaña-Esparza, María; Conesa-Hernández, Ana-María; Candel, Sergio; Cayuela-Fuentes, María-Luisa; Mulero, Victoriano; Tyrkalska, Sylwia-D (FRONTIERS MEDIA SA, 2026-01-06)
    Since the emergence of SARS-CoV-2 in late 2019, substantial efforts have been made to understand its mechanisms of pathogenicity. Although angiotensin-converting enzyme 2 (ACE2) has been identified as the main receptor for ...
  • Dual Role of DUOX1-Derived Reactive Oxygen Species in Melanoma 
    Pardo-Sánchez, Irene; Ibáñez-Molero, Sofia; García-Moreno, Diana; Mulero, Victoriano (MDPI, 2023-03)
    Melanoma is the most serious type of skin cancer. Inflammation and oxidative stress play an essential role in the development of several types of cancer, including melanoma. Although oxidative stress promotes tumor growth, ...
  • Dual-Chamber Pacing With Closed Loop Stimulation in Recurrent Reflex Vasovagal Syncope The SPAIN Study 
    Baron-Esquivias, Gonzalo; Morino, Carlos-A; Moya-Mitjans, Ángel; Martínez-Alday, Jesús; Ruiz-Granell, Ricardo; Lacunza-Ruiz, Francisco-Javier; García-Civera, Roberto; Gutiérrez-Carretero, Encarnación; Romero-Garrido, Rafael (ELSEVIER SCIENCE INC, 2017-10-03)
  • ¿Duele estar hospitalizado? 
    Mas-Castillo, Adelia; Parra-Hidalgo, Pedro; Ramón-Esparza, Teresa; Monteagudo-Piqueras, Olga; Nieto-Martínez, Pilar (2012)
  • Duodenal pseudolipomatosis. Literature review and case report of a very unusual finding 
    Agüera-Sánchez, Alfonso; Martínez-Diaz, Francisco; Pagán-Muñoz, Inmaculada; Martínez-Pérez, Matías; de-los-Reyes-Cano-Mármol, Purificación; Martínez-Martínez, Irene; Zaragoza-Huesca, David; García-Molina, Francisco (ARAN Ediciones S.L, 2024)
    Pseudolipomatosis (PL) is a rare, benign, iatrogenic condition first described in colorectal mucosa. This condition is thought to arise from gas penetration into the mucosa due to mechanical or chemical injury during ...
  • Dupilumab in Difficult-to-treat Chronic Spontaneous Urticaria: A Real-world Multicentre Cohort Study 
    Planella-Fontanillas, Nidia; Berna-Rico, Emilio; Figueras-Nart, Ignasi; Spertino, Jorge; Dols-Casanov, Lluis; Gatica-Ortega, María-Elena; Exposito-Serrano, Vicente; Lasheras-Pérez, Miguel-Antonio; Rodríguez-Serna, Mercedes; Mascaro-Jr, José-M; Mele-Ninot, Gemma; Mercader-García, Pedro; Navarro-Trivino, Francisco-José; Tous-Romero, Fatima; Elosua-González, Marta; Magdaleno-Tapial, Jorge; Pérez-Ferriols, Amparo; Montero-Vilchez, Trinidad; Torne-Gutiérrez, José-Ignacio; Gallardo, Fernando; Pesque, David; Pujol, Ramón-M; Serra-Baldrich, Esther; Giménez-Arnau, Ana-María (ACTA DERMATO-VENEREOLOGICA, 2026-07-06)
    Chronic spontaneous urticaria (CSU) remains difficult to manage in patients refractory to antihistamines and omalizumab. Although dupilumab has recently been approved and incorporated into international guidelines, real-world ...
  • Durability of bioprosthetic aortic valve replacement in patients under the age of 60 years-1-year follow-up from the prospective INDURE registry 
    Meuris, Bart; Roussel, Jean-Christian; Borger, Michael-A; Siepe, Matthias; Stefano, Pierluigi; Laufer, Guenther; Langanay, Thierry; Theron, Alexis; Grabenwoeger, Martín; Binder, Konrad; Demers, Philippe; Pessotto, Renzo; van-Leeuwen, Wouter; Bourguignon, Thierry; Cánovas, Sergio; Mariscalco, Giovanni; Coscioni, Enrico; Dagenais, Francois; Wendler, Olaf; Polvani, Gianluca; Eden, Matthias; Botta, Beate; Bramlage, Peter; de-Paulis, Ruggero (OXFORD UNIV PRESS, 2023-10)
    OBJECTIVES: We report 1-year safety and clinical outcomes in patients <60 years undergoing bioprosthetic surgical aortic valve intervention. METHODS: The INSPIRIS RESILIA Durability Registry is a prospective, multicentre ...
  • Durability of bioprosthetic aortic valves in patients under the age of 60years-rationale and design of the international INDURE registry 
    Meuris, Bart; Borger, Michael-A; Bourguignon, Thierry; Siepe, Matthias; Grabenwoger, Martín; Laufer, Gunther; Binder, Konrad; Polvani, Gianluca; Stefano, Pierluigi; Coscioni, Enrico; van-Leeuwen, Wouter; Demers, Philippe; Dagenais, Francois; Cánovas, Sergio; Theron, Alexis; Langanay, Thierry; Roussel, Jean-Christian; Wendler, Olaf; Mariscalco, Giovanni; Pessotto, Renzo; Botta, Beate; Bramlage, Peter; de-Paulis, Ruggero (BMC, 2020-05-27)
    BACKGROUND: There is an ever-growing number of patients requiring aortic valve replacement (AVR). Limited data is available on the long-term outcomes and structural integrity of bioprosthetic valves in younger patients ...
  • Durvalumab plus platinum-etoposide in the first-line treatment of extensive-stage small cell lung cancer (CANTABRICO): A single-arm clinical trial 
    Isla, Dolores; Zugazagoitia, Jon; Arriola, Edurne; García-Campelo, Rosario; Marti-Blanco, Cristina; Diz-Tain, María-Pilar; López-Brea, Marta; Moreno-Vega, Alberto-Luis; León-Mateos, Luis; Oramas, Juana; Gutiérrez-Calderón, Vanesa; Majem, Margarita; Sánchez-Hernández, Alfredo; Aguado, Carlos; Álvarez-Cabellos, Ruth; Massuti, Bartomeu; Moreno, Amaia; Firvida-Pérez, José-Luis; Valdivia, Javier; González-Cordero, Marta; Zafra-Poves, Marta; Domine, Manuel; García-Navalon, Francisco-Javier; Villanueva, Noemi; Provencio, Mariano; Juan-Vidal, Oscar; Rivas-Corredor, Carlos; Olmedo-García, María-Eugenia; Palmero, Ramón; López-Castro, Rafael; Carcereny, Enric; Lechuga, José-Luis; Domínguez, Marta; Callejo, Ángel; Paz-Ares, Luis (ELSEVIER IRELAND LTD, 2025-11)
    BACKGROUND: Immunotherapy trials involving patients with extensive-stage small cell lung cancer (ES-SCLC) from real-world clinical practice are needed. We aimed to evaluate the safety and effectiveness of durvalumab plus ...
  • Durvalumab plus tremelimumab for the treatment of advanced neuroendocrine neoplasms of gastroenteropancreatic and lung origin 
    Capdevila, Jaume; Hernando, J; Teule, A; López, C; García-Carbonero, R; Benavent, M; Custodio, Ana-Belén; García-Álvarez, A; Cubillo, A; Alonso, V; Carmona-Bayonas, Alberto; Alonso-Gordoa, Teresa; Crespo, G; Jiménez-Fonseca, Paula; Blanco, M; Viudez, A; La-Casta, Adelaida; Sevilla, I; Segura, A; Llanos, M; Landolfi, S; Nuciforo, P; Manzano, José-Luis (NATURE PORTFOLIO, 2023-05)
    Single immune checkpoint blockade in advanced neuroendocrine neoplasms (NENs) shows limited efficacy; dual checkpoint blockade may improve treatment activity. Dune (NCT03095274) is a non-randomized controlled multicohort ...
  • Durvalumab plus tremelimumab for the treatment of patients with progressive, refractory advanced thyroid carcinoma: the phase II GETNE-DUTHY trial 
    Capdevila, Jaume; Hernando, Jorge; Molina-Cerillo, Javier; Plana-Serrahima, María; Taberna-Sanz, Miren; Castelo, Beatriz; Álvarez-Escola, Cristina; Carmona-Bayonas, Alberto; Ballester-Navarro, Inmaculada; Iglesias, Lara; Bover, Mateo; García-Álvarez, Alejandro; Lavernia, Javier; Yaya-Tur, Ricardo; Ruiz, Sofía; Baste, Neus; Lorenzo-Lorenzo, Isabel; Sánchez-Hernández, Alfredo; Sanz-García, Enrique; Marquina, Gloria; Nuciforo, Paolo; Elguero, Belén; Grande, Enrique; Alonso-Gordoa, Teresa (SPRINGERNATURE, 2026-04-04)
    Single-agent PD-1 blockade demonstrated promising efficacy in advanced thyroid cancer. The phase II, single-arm, multi-cohort GETNE-DUTHY trial (clinicaltrials.gov NCT03753919, EudraCT 2018-001066-42) aimed to determine ...
  • Dynamic analysis of muscles and the internal structure of the peripheral nerve as biomarkers of amyotrophic lateral sclerosis: a pilot study with ultrasound imaging 
    López-Navarro, C; Serrano-Valero, M; Fages-Caravaca, EM; Martínez-Paya, JJ; del-Bano-Aledo, ME; Rios-Diaz, J (ELSEVIER ESPANA SLU, 2024-07)
    INTRODUCTION: The aim of this study was to determine the behaviour of ultrasound biomarkers of fascicle density and muscle strength in patients with amyotrophic lateral sclerosis (ALS). METHODS: We conducted an observational, ...
  • Dynamic assessment of CHA2DS2-VASc and HAS-BLED scores for predicting ischemic stroke and major bleeding in atrial fibrillation patients 
    Serna, María-José; Rivera-Caravaca, José-Miguel; López-Gálvez, Raquel; Soler-Espejo, Eva; Lip, Gregory-YH; Marín, Francisco; Roldán-Schilling, Vanessa (EDICIONES DOYMA S A, 2024-10)
    INTRODUCTION AND OBJECTIVES: Stroke and bleeding risks in atrial fibrillation (AF) are often assessed at baseline to predict outcomes years later. We investigated whether dynamic changes in CHA(2)DS(2)-VASc and HAS-BLED ...
  • Dynamic Changes in Oxidative Stress and Epigenetic Modifications in the Ventral Mesencephalon and Striatum of MPTP-Treated Mice: Implications for Parkinson's Disease Pathogenesis 
    Gallo-Soljancic, Pablo; De-Stefano, María-Egle; González-Cuello, Ana-María; Fernández-Villalba, Emiliano; Godderis, Lode; Herrero, María-Trinidad (SPRINGER, 2025-08)
    This study investigates the effects of an acute 1-metil 4-fenil 1,2,3,6-tetraidro-piridina (MPTP) treatment, a known inducer of parkinsonism, on oxidative stress and epigenetic changes in the mouse ventral midbrain (VM) ...
  • Dynamic Lysine Acetylation Disrupts Isocitrate Lyase Function and Enables Metabolic Optimisation 
    Martínez-Vivancos, Adrián; Gomariz-Turpin, Beatriz; Lozano-Terol, Gema; Sola-Martínez, Rosa-Alba; Ortega, Álvaro; Gallego-Jara, Julia; de-Diego-Puente, Teresa (WILEY, 2026-04)
    Proteomic studies have suggested that Escherichia coli isocitrate lyase (ICL) undergoes multiple acetylation events, partially inhibiting its activity. However, the molecular basis of this regulation and the contribution ...
  • Dynamic Remodeling of the Zona Pellucida: Implications for Oocyte Competence and Assisted Reproduction 
    de-la-Fuente, Daniel; Prestianni, Michela; Navarrete-López, Paula; García-Merino, Cristina; Balastegui-Alarcón, Miriam; Soria, Pilar; Avilés, Manuel; Rizos, Dimitrios; Gutiérrez-Adan, Alfonso (MDPI, 2025-11-17)
    The zona pellucida (ZP) is a glycoprotein-rich extracellular matrix essential for fertilization, early embryonic development, and implantation. Beyond its core functions, the ZP undergoes dynamic remodeling during oocyte ...