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  • P2X7 receptor activation impairs antitumour activity of natural killer cells 
    Baroja-Mazo, Alberto; Penin-Franch, Alejandro; Lucas-Ruiz, Fernando; De-Torre-Minguela, Carlos; Alarcón-Vila, Cristina; Hernández-Caselles, Trinidad; Pelegrín, Pablo (WILEY, 2023-01)
    BACKGROUND AND PURPOSE: A high number of intratumoural infiltrating natural killer (NK) cells is associated with better survival in several types of cancer, constituting an important first line of defence against tumours. ...
  • P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis 
    Martínez-García, Juan-José; Martínez-Banaclocha, Helios; Angosto-Bazarra, Diego; de-Torre-Minguela, Carlos; Baroja-Mazo, Alberto; Alarcón-Vila, Cristina; Martínez-Alarcón, Laura; Amores-Iniesta, Joaquín; Martín-Sánchez, Fatima; Ercole, Giovanni-A; Martínez, Carlos-M; González-Lisorge, Ada; Fernández-Pacheco, José; Martínez-Gil, Piedad; Adriouch, Sahil; Koch-Nolte, Friedrich; Lujan, Juan; Acosta-Villegas, Francisco; Parrilla-Paricio, Pascual; García-Palenciano, Carlos; Pelegrín, Pablo (NATURE PORTFOLIO, 2019-06-20)
    Sepsis is characterized by a systemic inflammatory response followed by immunosuppression of the host. Metabolic defects and mitochondrial failure are common in immunocompromised patients with sepsis. The NLRP3 inflammasome ...
  • P2X7 receptor induces Tumor necrosis Factor-a converting enzyme activation and release to Boost TnF-ae Production 
    Barberá-Cremades, María; Gómez, Ana-I; Baroja-Mazo, Alberto; Martínez-Alarcón, Laura; Martínez, Carlos-M; de-Torre-Minguela, Carlos; Pelegrín, Pablo (FRONTIERS MEDIA SA, 2017-07-24)
    Tumor necrosis factor (TNF)-? is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-? release is controlled by the activity of TNF-? converting enzyme (TACE) that cut membrane-bound ...
  • Pacritinib prevents inflammation-driven myelofibrosis-like phenotype in a miR-146a-/- murine model 
    Cuenca-Zamora, Ernesto-José; Martínez, Constantino; Morales, María-Luz; Guijarro-Carrillo, Pedro-Jesús; López-Poveda, María-José; Alcolea-Guardiola, Carlos; Vidal-Garrido, Natalia; Lozano-Almela, María-Luisa; González-Conejero, Rocío; Teruel-Montoya, Raúl; Ferrer-Marín, Francisca (Elsevier Masson s.r.l., 2024)
    Chronic proinflammatory signaling is a characteristic trait in myeloproliferative neoplasms (MPN), particularly myelofibrosis (MF). Aberrant inflammatory signaling, particularly from NF-?B pathway, exacerbates the progression ...
  • Paediatric endoscopy in Spain: Current situation and recent developments 
    Rubio, María-Navalon; Casano, Carmen-Jovani; Soria-López, Marta; Rodríguez-Herrera, Alfonso; López-Casado, Miguel-Ángel; Navas-López, Víctor-Manuel; Miravet, Víctor-Vila (EDICIONES DOYMA S A, 2024-12)
    INTRODUCTION: Paediatric gastrointestinal endoscopy (pGIE) has advanced significantly over the last decade, with increased diagnostic and therapeutic applications. OBJECTIVES: This study examines the current state of pGIE ...
  • Palatopharyngeal Arch Staging System (PASS): Consensus about Oropharyngeal Evaluation 
    Morato, Marta; Cardona-Sosa, Maribel-P; Bosco, Gabriela; Pérez-Martín, Nuria; Marte-Bonilla, Mayerin-M; Marco, Alfonso; O'Connor-Reina, Carlos; Lugo, Rodolfo; Plaza-Mayor, Guillermo (MDPI, 2023-03)
    Intraoral examinations are essential in the evaluation of the upper airway in patients with obstructive sleep apnea (OSA). The morphology of the anatomic structures of the soft palate, the tonsillar fossae, and the ...
  • Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition 
    Breeur, Marie; Ferrari, Pietro; Dossus, Laure; Jenab, Mazda; Johansson, Mattias; Rinaldi, Sabina; Travis, Ruth-C; His, Mathilde; Key, Timothy-J; Schmidt, Julie-A; Overvad, Kim; Tjonneland, Anne; Kyro, Cecilie; Rothwell, Joseph-A; Laouali, Nasser; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena-A; Schulze, Matthias-B; Eichelmann, Fabian; Palli, Domenico; Grioni, Sara; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, Bas; Olsen, Karina-Standahl; Sandanger, Torkjel-Manning; Nost, Therese-Haugdahl; Quirós, José-Ramón; Bonet, Catalina; Rodríguez-Barranco, Miguel; Chirlaque-López, María-Dolores; Ardanaz, Eva; Sandsveden, Malte; Manjer, Jonas; Vidman, Linda; Rentoft, Matilda; Muller, David; Tsilidis, Kostas; Heath, Alicia-K; Keun, Héctor; Adamski, Jerzy; Keski-Rahkonen, Pekka; Scalbert, Augustin; Gunter, Marc-J; Viallon, Vivian (BMC, 2022-10)
    BACKGROUND: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites ...
  • Pan-retinal ganglion cell markers in mice, rats, and rhesus macaques 
    Nadal-Nicolás, Francisco-M; Galindo-Romero, Caridad; Lucas-Ruiz, Fernando; Marsh-Amstrong, Nicholas; Li, Wei; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta (SCIENCE PRESS, 2023-01-18)
    Univocal identification of retinal ganglion cells (RGCs) is an essential prerequisite for studying their degeneration and neuroprotection. Before the advent of phenotypic markers, RGCs were normally identified using ...
  • Pancreas units within gastroenterology departments. Organizational and operational standards for a patient-centered service 
    Domínguez-Muñoz, JEnrique; Martínez-Moneo, Emma; Bolado-Concejo, Federico; Alberca-de-las-Parras, Fernando; Carballo-Álvarez, Fernando; Elola-Somoza, F-Javier (Arán Ediciones, 2024)
    The Asociación Española de Pancreatología (AESPANC), Asociación Española de Gastroenterología (AEG), and Sociedad Española de Patología Digestiva (SEPD) have developed a consensus document on the standards and recommendations ...
  • Pancreatic encephalopathy, a little known complication of acute pancreatitis 
    Albacete-Ródenas, Paloma; Ortiz-Sánchez, María-Luisa; Gajownik, Urszula; Alberca-de-las-Parras, Fernando; Pons-Miñano, José-Antonio (Arán Ediciones, 2022)
    A 62-year-old male presented with severe post-endoscopic retrograde cholangiopancreatography (post-ERCP) acute pancreatitis. He required admission to the Intensive Care Unit (ICU) twice due to respiratory and renal failure ...
  • Pancreatic metastasis of Merkel-cell carcinoma: A rare neoplasm of the pancreas 
    Sánchez-Melgarejo, José-Francisco; Sánchez-Fernández, María-Josefa; Alcaraz-Mateos, Eduardo (ARAN Ediciones S.A., 2020)
    Only 2-3.9% of pancreatic malignancies represent metastases from other sites, the most common origins being the lungs, kidneys, and gastrointestinal tract. Differentiating between primary and secondary lesions may be ...
  • Pancreatic neuroendocrine tumors. Our experience 
    Sánchez-Cifuentes, Ángela; Candel-Arenas, Marife; Luján-Martínez, Delia; Ruiz-Marín, Miguel; Albarracín-Marín-Blazquez, Antonio (MEXICAN ACAD SURGERY, 2019-01)
    Pancreatic neuroendocrine tumors are rare. It is a heterogeneous group of neoplasms with very different behavior and prognosis. They can appear sporadically or associated with genetic syndromes. They are divided into ...
  • Papel de la maniobra de Carnett en el diagnóstico de un síndrome por atrapamiento del nervio cutáneo anterior confundido con un trastorno por síntomas somáticos: a propósito de un caso 
    García-Carmona, Juan-Antonio; Sánchez-Lucas, J (Spanish Society of Neurology, 2021)
  • PAPILA: Dataset with fundus images and clinical data of both eyes of the same patient for glaucoma assessment 
    Kovalyk, Oleksandr; Morales-Sánchez, Juan; Verdú-Monedero, Rafael; Sellés-Navarro, Inmaculada; Palazón-Cabanes, Ana; Sancho-Gómez, José-Luis (NATURE PORTFOLIO, 2022-06)
    Glaucoma is one of the ophthalmological diseases that frequently causes loss of vision in today's society. Previous studies assess which anatomical parameters of the optic nerve can be predictive of glaucomatous damage, ...
  • Parachute mitral valve repair in adult patient with transitional atrioventricular septal defect 
    Aguilar, Juan-M; Jiménez, Antonio; Pérez-Andreu, Joaquín; Fernández, Manuel; Lorenzo, Maydelin; Cánovas-López, Sergio-J (ELSEVIER, 2022-05)
  • Paradigmatic De Novo GRIN1 Variants Recapitulate Pathophysiological Mechanisms Underlying GRIN1-Related Disorder Clinical Spectrum 
    Santos-Gómez, Ana; Miguez-Cabello, Federico; Julia-Palacios, Natalia; García-Navas, Deyanira; Soto-Insuga, Víctor; García-Penas, Juan-J; Fuentes, Patricia; Ibañez-Mico, Salvador; Cuesta, Laura; Cancho, Ramón; Andreo-Lillo, Patricia; Gutiérrez-Aguilar, Gema; Alonso-Luengo, Olga; Malaga, Ignacio; Hedrera-Fernández, Antonio; García-Cazorla, Ángels; Soto, David; Olivella, Mireia; Altafaj, Xavier (MDPI, 2021-12)
    BACKGROUND: GRIN-related disorders (GRD), the so-called grinpathies, is a group of rare encephalopathies caused by mutations affecting GRIN genes (mostly GRIN1, GRIN2A and GRIN2B genes), which encode for the GluN subunit ...
  • Parental Education and the Association between Fruit and Vegetable Consumption and Asthma in Adolescents: The Greek Global Asthma Network (GAN) Study 
    Antonogeorgos, George; Priftis, Kostas-N; Panagiotakos, Demosthenes-B; Ellwood, Philippa; García-Marcos, Luis; Liakou, Evangelia; Koutsokera, Alexandra; Drakontaeidis, Pavlos; Thanasia, Marina; Mandrapylia, María; Douros, Konstantinos (MDPI, 2021-04)
    BACKGROUND: Evidence suggests that nutritional factors, such as consumption of fruits and vegetables, along with socioeconomic factors such as parental education level, are associated with asthma prevalence. Our study ...
  • Parental education moderates the association between indoor moisture environment and asthma in adolescents: the Greek Global Asthma Network (GAN) cross-sectional study 
    Antonogeorgos, George; Liakou, Evangelia; Koutsokera, Alexandra; Drakontaeidis, Pavlos; Thanasia, Marina; Mandrapylia, María; Fouzas, Sotirios; Ellwood, Philippa; García-Marcos, Luis; Panagiotakos, Demosthenes-B; Priftis, Kostas-N; Douros, Konstantinos (BMC, 2022-03)
    OBJECTIVE: Asthma is a major contributor to childhood morbidity. Several environmental and socioeconomic status (SES) factors have been implicated in its etiopathogeneses such as indoor moisture and parental education ...
  • Parental Education Moderates the Relation between Physical Activity, Dietary Patterns and Atopic Diseases in Adolescents 
    Antonogeorgos, George; Panagiotakos, Demosthenes-B; Priftis, Kostas-N; Liakou, Evangelia; Koutsokera, Alexandra; Drakontaeidis, Pavlos; Thanasia, Marina; Mandrapylia, María; Moriki, Dafni; Ellwood, Philippa; García-Marcos, Luis; Douros, Konstantinos (MDPI, 2022-05)
    Background: Atopic diseases, particularly asthma, eczema, and rhinitis, are among the most common chronic diseases in childhood, with several factors implicated in their pathogenesis. Our study examined the role of parental ...
  • Parental presence during invasive pediatric procedures: what does it depend on? 
    Palomares-González, Laura; Hernández-Caravaca, Iván; Gómez-García, Carmen-Isabel; Sánchez-Solís-de-Querol, Manuel (UNIV SAO PAULO, ESCOLA DE ENFERMAGEM DE RIBEIRAO PRETO, 2023)
    OBJECTIVE: family-centered care during invasive procedures has been endorsed by many professional health care organizations. The aim of this study was to evaluate the health professionals' attitudes towards parental presence ...